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Taschenbuch. Zustand: Neu. Neuware -The principal goal of the Handbook of Behavioral Neurobiology is a systematic, critical, and timely exposition of those aspects of neuroscience that have direct and immediate bearing on overt behavior. In this first volume, subtitled 'Sensory Integration,' the subject matter has been subdivided and the authors selected with this particular goal in mind. Although the early chapters (on the phylogeny and ontogeny of sensory systems, and on the common properties of sensory systems) are somewhat too abstract to permit many direct behavioral inferences, the focus on behavior has been maintained there too as closely as is now possible. A behavioral orientation is most obvious in the remaining chapters, which layout for each sensory modality in turn what is now known about structure-behavior relationships. The handbook is primarily intended to serve as a ready reference for two types of readers: first, practicing neuroscientists looking for a concise and authori tative treatment of developments outside of their particular specialities; and second, students of one or another branch of neuroscience who need an overview of the persistent questions and current problems surrounding the relation of the perceptual systems to behavior. The requirements imposed by the decision to address these particular audiences are reflected in the scope and style of the chapters as well as in their content.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 596 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -It is now more than twenty years since a proposal was first mooted to hold an international tunnelling symposium in Britain. At the time of the first symposium, held in London in 1976, the Channel Tunnel pro ject had just been shelved. Last weekend a charity walk was held in the finished tunnel, which will be open for business later in the year. Tunnels have figured prominently, and at times spectacularly, in the development of national and international links and it is hoped that such links gather pace in the future. It is particularly pleasing that Alastair Biggart of Storebrelt has agreed to deliver the twenty-sixth Sir Julius Wernher Memorial Lecture of the Institution of Mining and Metallurgy, entitled 'The changing face of tunnelling', at the start of this event. \* Although almost every edition of the technical journals on tunnelling reports another £1 billion scheme somewhere in the world, it would be unfair of me to suggest that tunnelling is restricted to these prestigious schemes for major transport links. Much of the work that makes mod ern life possible receives hardly a mention outside the technical press and one suspects that society at large applies the 'out of sight, out of mind' attitude even more readily to underground construction than it does to other forms of engineering. Clearly, there is a contiiming need to improve the capacity and performance of our infrastructure, while hav ing a careful regard for the environment.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 848 pp. Englisch.

Buch. Zustand: Neu. Neuware -'In this book, Peter Bogetoft - THE expert on the theory and practice of benchmarking - provides an in¿depth yet very accessible and readable explanation of the best way to do benchmarking, starting from the ground up.'Rick AntleWilliam S. Beinecke Professor of Accounting, Yale School of ManagementCFO, Compensation Valuation, Inc.'I highly recommend this well-written and comprehensive book on measuring and managing performance. Dr. Bogetoft summarizes the fundamental mathematical concepts in an elegant, intuitive, and understandable way.'Jon A. ChilingerianProfessor, Brandeis University and INSEAD'Bogetoft gives in his book Performance Benchmarking an excellent introduction to the methodological basis of benchmarking.'Christian ParbølDirector, DONG Energy'This book is the primer on benchmarking for performance management.'Albert BirckBusiness Performance Manager, Maersk Oil'This excellent book provides a non technical introduction for performance management.'Misja MikkersDirector, Dutch Health Care Authority'With this very well written and comprehensive introduction to the many facets of benchmarking in hand, organizations have no excuse for not applying the best and cost effective benchmarking methods in their performance assessments.'Stig P. ChristensenSenior R&D Director, COWISpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 276 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - Included in this volume is a broad range of topics. Immunology is such a diverse field that many of the subspecialties overlap, and one finds it convenient and necessary to integrate information from several of them. We try to focus on the molecular aspects of immunology as much as is reasonable, but some con tributions consist of ablend of molecular and cellular immunology and even immunopathology. This is as it should be, since information at the molecular level often provides an explanation of phenomena observed at other levels. Myelin basic protein holds the interest of immunologists because it is impli cated in the induction of the autoimmune disease called experimental allergie encephalomyelitis (EAE). Although much biochemical and immunological information about this protein has been uncovered, it is not understood how such an inaccessible self-antigen can serve as the focal point in the central ner vous system for myelin basic protein-specific EAE-inducing T cells. Day dis cusses the problem by first reviewing the sequences of the proteins from several species and the antigenicity of the proteins and peptides derived from them. The reader is then led into a thorough discussion of the immunological relation ships that do and do not influence development of the encephalitis. From this discussion, the author promulgates the bystander model as the best overall mechanism to explain why different fragments of the highly conserved protein are needed by various species to give rise to the same type of localized central nervous system disease.

Taschenbuch. Zustand: Neu. Neuware - In their classic paper in 1929, Drury and Szent-Gyorgyi described a number of the important cardiovascular actions of adenosine. Another thirty years were to pass before the possible physiological role of adenosine in coronary vasodilation was studied by Berne and others. Since then, there has been a tremendous increase in research into the actions of adenosine. Workers from many disciplines have employed a wide variety of techniques, since adenosine is a product of and a substrate for a number of metabolic pathways, is transported into cells, and acts at discrete receptor sites to modulate the activity of adenylate cyclase and to produce important actions on many cells and tissues including platelets, adipo cytes, heart, blood vessels, and other smooth muscles. International symposia on the actions of adenosine were held in 1978, 1981, and 1982, and the proceedings of these symposia have been published (Baer and Drummond, 1979; Daly et at., 1983; Berne et at., 1983). Since it is not the primary purpose of the present volume to review our current understanding of the nu merous actions of adenosine, these volumes should be consulted for such details. Rather, the present volume has been planned to provide both graduate students and investigators in pharmacology and related disciplines with a summary of some of the methods now available for the study of the actions of adenosine and, in particular, to highlight their possible uses and limitations.

Taschenbuch. Zustand: Neu. Neuware - The Cell Biology of Fibroblast Cyclooxygenase.- Arachidonic Acid Metabolism During Interactions Between Glomerular and Bone Marrow-derived Cells.- Lipoxygenase Products and Their Functions in Glomeruli.- The Development of New Antileukotriene Drugs: Specific Leukotriene D4 Antagonists and 5-Lipoxygenase Inhibitors.- The Renal Cytochrome P450 System Generates Novel Arachidonic Acid Metabolites.- The Biosynthesis and Actions of Prostaglandins in the Renal Collecting Tubule and Thick Ascending Limb.- Peptide Hormones, Cytosolic Calcium and Renal Epithelial Response.- Prostaglandins, Thromboxane and Leukotrienes in the Control of Mesangial Function.- Interactions of Platelet Activating Factor and Prostaglandins in the Glomerulus and in Mesangial Cells.- Eicosanoids and Platelet Activating Factor as Possible Mediators of Injury in Experimental Nephropathies.- Eicosanoids: Role in Experimental Renal Disease.- Abnormalities of Glomerular Eicosanoid Metabolism in States of Glomerular Hyperfiltration.- Diabetic Nephropathy: Pathophysiology, Clinical Course and Susceptibility.- The Molecular, Biochemical and Human Pharmacology of Thromboxane A2 in Renal Disease.- Studies of Renal Eicosanoid Synthesis In Vivo and In Vitro.- The Role of Eicosanoids in Human Glomerular Disease.

Taschenbuch. Zustand: Neu. Neuware - 1. A Model for the North Atlantic.- 2. The Geology of the Bahama-Blake Plateau Region.- 3. The Continental Margin of Eastern North America, Florida to Newfoundland.- 4. The Northeastward Termination of the Appalachian Orogen.- 5. An Outline of the Geology of the Atlantic Coast of Greenland.- 6. The Scandinavian Caledonides.- 7. The Geology of the Southern Termination of the Caledonides.- 8. The Geology of the Western Approaches.- 9. The Geology and Sedimentation History of the Bay of Biscay.- 10. Geology of West Africa and Canary and Cape Verde Islands.- 11. Cenozoic to Recent Volcanism in and around the North Atlantic Basin.- 12. The Oceanic Islands: Azores.- 13. Tectonic and Radiometric Age Comparisons.- 14. The Geophysics of the North Atlantic Basin.

Taschenbuch. Zustand: Neu. Neuware - More than for any other volume of the Handbook of Neurochemistry, the chap ters in this volume on Pathological Neurochemistry deal with the interface of the laboratory bench with the patient's bedside. Most of the chapters reflect the confluence of basic scientists, clinical investigators, and physicians. Con sidered here are many of the more important disorders that afflict the nerves, muscles, spinal cord, and/or brain of mankind throughout the world. There are well over 500 such disorders. And our understanding of their nature and of measures for effective prevention or treatment depends significantly on appli cation of the biochemical disciplines that characterize neurochemistry. Before World War II, any attempt to compile a volume on pathological neurochemistry would have been largely descriptive and very rudimentary, as such 'handbooks' by Hans Winterstein (1929), Irvine Page (1937), and others demonstrate. But thanks to the many major advances in research and tech nology in the postwar decades, we now stand at the threshold of understanding how to manage many of the major neurological disorders, and we may expect more such delineations in the immediate decades ahead. Neurochemistry, de fined broadly, has played a central role in this extraordinary turn of events, progressing from what J. L. W, Thudichum in 1884 called objects of anxious empiricism to his anticipation of the proud exercise of chemical precision.

Taschenbuch. Zustand: Neu. Neuware - In 1968 Drs. B. E. C. Nordin and A. Hodgkinson organized the First International Symposium on Urolithiasis Research in Leeds, England. One hundred and five participants from continental Europe, Great Britain, and the United States met to review their work and exchange ideas regarding the formation of urinary calculi. This meeting achieved several important goals. It pulled together a nidus of workers in the many scientific disciplines that relate to urolithiasis. This nidus served as the seed for research growth in a complex, interdisciplinary field. It established a forum for con tinuing communication in urolithiasis research with subsequent sym posia being held every 4 years. The Williamsburg Symposium was the fourth in the Leeds-Madrid Davos series involving 186 participants from throughout the world. A stated emphasis was on clinical research under way in the field. There were no invited speakers and for the first time the 41 papers that were presented orally at the meeting were selected from 184 submitted abstracts. A total of 134 papers were presented in the poster sessions in the afternoons where informal exchange between interested participants and investigators could occur without the restrictions of a plenary session. Virtually all areas of urolithi asis research from the most fundamental physical chemistry to clinical patterns of disease and specific modes of treatment were presented, reviewed and discussed during the meeting.

Taschenbuch. Zustand: Neu. Neuware - It is now well known that the concept of drifting continents became an estab lished theory during the 1960s. Not long after this 'revolution in the earth sciences,' researchers began applying the continental drift model to problems in historical biogeography. One such problem was the origin and dispersal of the New World monkeys, the Platyrrhini. Our interests in this subject began in the late 1960s on different conti nents quite independent of one another in the cities of Florence, Italy, and Berkeley, California. In Florence in 1968, A. B. Chiarelli, through stimulating discussions with R. von Koenigswald and B. de Boer, became intrigued with the possibility that a repositioning of the continents of Africa and South America in the early Cenozoic might alter previous traditional conceptions of a North American origin of the Platyrrhini. During the early 1970s this con cept was expanded and pursued by him through discussions with students while serving as visiting professor at the University of Toronto. By this time, publication of the Journal of Human Evolution was well underway, and Dr. Chiarelli as editor encouraged a dialogue emphasizing continental drift models of primate origins which culminated in a series of articles published in that journal during 1974-75. In early 1970, while attending the University of California at Berkeley, R. L. Ciochon was introduced to the concept of continental drift and plate tectonics and their concomitant applications to vertebrate evolution through talks with paleontologist W. A. Clemens and anthropologist S. L. Washburn.

Taschenbuch. Zustand: Neu. Neuware - The necessity of prediction and fine control in the food manufacturing process is becoming more important than ever before, and food researchers and engineers must confront difficulties arising from the specificity of food materials and the sensitivity of human beings to taste. Fortunately, an overview of world research reveals that the mechanisms of the many complex phenomena found in the food manufacturing process have been gradually elucidated by skilful experiments using new analytical tools, methods and theoretical analyses. This book, the proceedings of the 6th International Congress on Engineering and Food (ICEF6), held for the first time in Asia - in Chiba, Japan May 23 -27, 1993 - summarizes the frontiers of world food engineering in 1993. Congress was joined by the 4th International Conference on Fouling and Cleaning. There were 476 active members from 31 countries participating in the Congress. The editors hope that readers will find this book to be a useful review of the current state of food engineering, and will consider future developments in this research field. The editors extend thanks to the members of the organizing committee of ICEF6, and the advisors, Dr. Ryozo Toei, Professor Emeritus of Kyoto University and Dr. Masao Fujimaki, Professor Emeritus of the University of Tokyo. They also acknowledge the international advisory board members who helped the organizing committee in many ways, and the 10 foundations and 66 companies that financially supported the ICEF6. Finally, the editors are indebted to the reviewers of the manuscripts of these proceedings.

Taschenbuch. Zustand: Neu. Neuware - TRACK 1: Innovative Applications in the Public Sector The integration of multimedia based applications and the information superhighway fundamentally concerns the creation of a communication technology to support the ac tivities of people. Communication is a profoundly social activity involving interactions among groups or individuals, common standards of exchange, and national infrastruc tures to support telecommunications activities. The contributions of the invited speakers and others in this track begin to explore the social dimension of communication within the context of integrated, information systems for the public sector. Interactions among businesses and households are described by Ralf Strauss through the development within a real community of a 'wired city' with information and electronic services provided by the latest telecommunications technologies. A more specific type of interaction between teacher and student forms the basis of education. John Tiffin demonstrates how virtual classrooms can be used to augment the educational process. Carl Loeffler presents yet another perspective on interaction through the integration of A-life and agent technologies to investigate the dynamics of complex behaviors within networked simulation environments. Common standards for communication in the form of electronic documents or CSCW (Computer Supported Cooperative Work), according to Roland Traunmiiller, provide en abling technologies for a paradigm shift in the management of organizations. As pointed out by William Olle, the impact of standardization work on the future of information technology depends critically upon the interoperability of software systems.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This survey of 13 electrooptic materials includes both a review and compilation of all materials properties relevant to their use in linear (Pockels) electrooptic modulator applications. Information on actual electrooptic modulator design as well as applications for these materials, and data on materials exhibiting a quadratic (Kerr) electrooptic effect, are not included. With these restrictions in mind, every attempt was made to be as comprehensive as possible by utilizing all available sources of literature: books, periodicals, reports, and vendor literature. The files of the Electronic Properties Information Center and full resources of the Hughes Aircraft Company Library were searched for pertinent data, and approximately 1000 articles were reviewed for this pUblication. A brief Introduction to the survey is followed by a description of the Prin ciples of Electrooptic Modulation, emphasizing the importance of crystal symmetry on the electrooptic properties of materials, and including the relationships between the electrooptic, piezooptic, elastooptic and piezoelectric effects in crystals. The survey consists of 13 independent sections, each section covering the properties of one material: crystallographic, optical, electrooptic, photoelastic, piezoelectric, dielectric and thermal. References appearing in the text are listed at the conclusion of each section. Tables and Figures are numbered separately for each section. v TABLE OF CONTENTS INTRODUCTION . - . . . . . 1 PRINCIPLES OF ELECTROOPTIC MODULATION. 5 AMMONIUM DIHYDROGEN ARSENATE (ADA) . 15 AMMONIUM DIHYDROGEN PHOSPHATE (ADP). 268 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Rapid advances in knowledge have led to an increasing interest in neuro biology over the last several years. These advances have been made possible, at least in part, by the use of increasingly sophisticated methodology. Furthermore, research in the most rapidly advancing areas is essentially multidisciplinary and is characterized by contributions from many investi gators employing a variety of techniques. While a grasp of fundamental neurobiological concepts is an obvious prerequisite for those who wish to follow or participate in this field, critical awareness and evaluation of neurobiological research also requires an understanding of sophisticated methodologies. The objective of Methods in Neurobiology is the development of such critical abilities. The reader is exposed to the basic concepts, principles, and instrumentation of key methodologies, and the application of each meth odology is placed in the special context of neurobiological research. The reader will gain familiarity with the terminology and procedures of each method and the ability to evaluate results in light of the particular features of neurobiological preparations and applications. 616 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -THE PHYSICAL BASIS FOR HETEROGENEOUS CATALYSIS is the proceedings of the ninth Battelle Colloquium in the Materials Sciences, held in Gstaad, Switzerland, September 2-6, 1974. It took as its theme the application of modern theoretical and experimental surface physics to heterogeneous catalysis. Progress in the field by classical chemical methods seemed to have slowed down, at a time when the need for better catalysts was particularly great. The Organizing Committee thought it might be possible to accelerate progress by the application of the powerful techniques evolved in recent years for studying atomically clean surfaces. However, the translation of ideas derived from clean single crystal surfaces with well characterized chemisorbed layers to real catalysts with high ratios of surface to mass on which reactions were taking place and requiring transport of mass and energy is a giant step, raising many questions and requiring thorough discussion by surface physicists on the one hand and catalytic chemists on the other. The 1974 Battelle Colloquium provided a forum for this exchange. As its usual custom, the Colloquium started the first day of introduc tory lectures by three distinguished scientists who have contributed impor tantly over many years to this field. 628 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Interest in biological rhythms has been traced back more than 2,500]ears to Archilochus, the Greek poet, who in one of his fragments suggests ',(i,(VWO'KE o'olos pv{}J.tos txv{}pW7rOVS ~XH' (recognize what rhythm governs man) (Aschoff, 1974). Reference can also be made to the French student of medicine J. J. Virey who, in his thesis of 1814, used for the first time the expression 'horloge vivante' (living clock) to describe daily rhythms and to D. C. W. Hufeland (1779) who called the 24-hour period the unit of our natural chronology. However, it was not until the 1930s that real progress was made in the analysis of biological rhythms; and Erwin Bunning was encouraged to publish the first, and still not outdated, monograph in the field in 1958. Two years later, in the middle of exciting discoveries, we took a breather at the Cold Spring Harbor Symposium on Biological Clocks. Its survey on rules considered valid at that time, and Pittendrigh's anticipating view on the temporal organization of living systems, made it a milestone on our way from a more formalistic description of biological rhythms to the understanding of their structural and physiological basis. 588 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The primary purpose of this book is to bring to the attention of members of the medical and scientific communities, as well as to other interested persons, a new and expanding area of investigation that features the use of chemicals for the prevention of tumor induction and development. This novel use of chemical compounds has succeeded in producing a remarkable series of discoveries in recent years. Some of these are beginning to be evaluated in the field of clinical oncology in a manner that has potentially enormous public health implications. It is anticipated, therefore, that increasing amounts of time, energy, and financial resources will be devoted to the further development and expansion of this work. The major contribution of this book at the present time is that it summarizes and brings up to date the pioneering efforts of the various scientists who originated this new and exciting field of scientific activity. The thoughts expressed by Louis Pasteur in 1884 may soon be applicable in the fight against cancer: 'When meditating over a disease, I never think of finding a remedy for it, but instead a means of preventing it. ' The emphasis on cancer prevention currently underway is the result, in part, of an increased awareness that the environment-geographical, cultural, and occupational-has a role in development of the disease. 248 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Aging is one of the most serious and costly health problems in the Western world. A disproportionate amount of the available health care capability is devoted to the health care of the aged and the cost of this care is soaring. Viewed in wide perspective, aging presents two problems for the researcher's consideration. First is that of providing the most efficacious therapeutic regi mens and the best possible care for those already in their latter years. The second is to determine the cause or causes for senes cence and all its attendant problems in order to decrease the im pact of senescence on general health and well being. This volume is aimed at examining possible relationships be tween biological time structure and aging and ways by which these interrelationships might be examined in terms of both the causes of senescence and the management of health problems of the elderly. The purpose of the volume is to stir the interests of chronobiolo gists in gerontology and those of gerontologists and geriatricians in chronobiology. 356 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The subject of this book is neuroendocrinology, that branch of biological science devoted to the interactions between the two major integrative organ systems of animals-the endocrine and nervous systems. Although this science today reflects a fusion of endocrinology and neurobiology, this synthetic ap proach is relatively recent. At the beginning of the 20th century, when the British physiologists, Bayliss and Starling, first proposed endocrinology to be an independent field of inquiry, they went to great lengths to establish the autonomy of chemical secretions in general and their independence from nervous control in particular (Bayliss, W. M. , and Starling, E. H. , 1902, The mechanism of pancreatic secretion,]. Physiol. 28:325). They argued with Pav lov, who said that there was a strong influence of the nervous system on the gastrointestinal phenomena the endocrinologists were studying. For several decades, the English physiologists prevailed, at least in the West; and Pavlov's critique was not taken to heart by the practitioners of the newly emerging discipline of endocrinology. Through the work of Harris, the Scharrers, Sawyer, Everett, and others, there has been something of a scientific detente in the latter half of this century; the hybrid field of neuroendocrinology is now regarded as one of the corner stones of modern neural science and is of fundamental importance in basic and clinical endocrinology. 588 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The third annual International Industrialization Symposium on the SuperCollider, IISSC-held March 13-15, 1991, in Atlanta, Ga.-was an enormous success. The number of attendees, exhibitors, and representatives from foreign countries surpassed the totals of previous years. There were 740 attendees, representing more than 2 dozen universities and colleges, 32 states, 9 national labs, 6 research centers, several government entities at the local, state, and federal level, 182 businesses & industry and 14 countries. More than 100 exhibits, sponsored by 85 organizations, added to the excitement. 'Getting Down to Business' was the theme of this year's Symposium. The fact that the Superconducting SuperCollider (SSC) is indeed underway was the message delivered by the Symposium's keynote speaker, Dr. Roy Schwitters, and expanded upon by the opening plenary speakers. The project is moving from the planning stage to actual construction, to development and procurement of equipment, and to resolution of the technical issues involved in advancing the state-of-the-art in areas such as theory, controls, systems, metallurgy, quality control, management, cryogenics, power systems, detectors, interagency cooperation and funding. Plenary speakers included: Paul Gilbert, Chairman of Parsons Brinckerhoff Quade & Douglas, Inc. 1256 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The conference entitled 'The Translational Apparatus' was held in Berlin from October 31 to November 5, 1992, in honorem et memoriam of H. G. Wittmann. The presentations of the rewarding, enjoyable and scientifically exciting week in Berlin were a fitting appreciation of this great man, and all participants and speakers contributed to the success of the meeting. The second reason for holding the Berlin meeting was to convene a group of scientists for a state-of-the-art presentation on ribosomes and related subjects; the outcome is this book. We have broadened the spectrum of topics to cover activities preceding and following pure ribosomal functions, such as 'Synthetases' and 'Protein Sorting', respectively, and we took the liberty of ordering the contributions in a way which does not always reflect the order of speakers. We are grateful to the authors who patiently tolerated our organization and our regulations for manuscripts. K.H. Nierhaus F. Franceschi A.R. Subramanian v CONTENTS I. tRNA and Aminoaeyl-tRNA Synthetases 1. The Crystal Structure of SeryI-tRNA Synthetase and its Complexes with A TP and tRNASer. 1 S. Cusack, C. Berthet-Colominas, V. Biou, F. Borel, M. Fujinaga, M. Hartlein, I. 764 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -These proceedings report the lectures and seminars presented at the NATO Advanced Study Institute on 'Optical Properties of Ions in Solids,' held at Erice, Italy, June 6-21, 1974. The Institute was the first activity of the International School of Atomic and Molecular Spectroscopy of the 'Ettore Majorana' Centre for Scientific Culture. The Institute consisted of a series of lectures on optical properties of ions in solids that, starting at a fundamental level, finally reached the current level of research. The sequence of lectures and the organization of the material taught were in keeping with a didactical presentation. In essence the Institute had the two-fold purpose of organizing what was known on the subject, and updating the knowledge in the field. Fif'teen series of lectures for a total of 44 hours were given. Five one-hour seminars and five twenty-minute seminars were presented. A total of 57 participants came from 40 laboratories in the following countries: Belgium, Canada, France, Germany, Ireland, Israel, Italy, Netherlands; Polatid, Romania, Switzerland, the United Ki~gdom, and the United States. The secretaries of the Institute were: D. Pacheco for the scientific aspects and A. La Francesca for the administrative aspects of the meeting. These proceedings report the lectures, the one-hour seminars (abstracts only) and the twenty-minute- seminars (titles only). The proceedings report also the contributions sent by Prof. K. Rebane and Dr. L. A. Rebane who, unfortunately, were not able to come. 512 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume V deals with the problems of turnover in the nervous system. 'Turnover' is defined in different ways, and the term is used in different contexts. It is used rather broadly in the present volume, and intentionally so. The turnover of macromolecules is only one aspect; here 'turnover' in dicates the simultaneous and coordinated formation and breakdown of macromolecular species. The complexities of cerebral protein turnover are shown in a separate chapter dealing with the synthesis of proteins, in another on breakdown, and in still another on the relationship of these two (showing how the two halves of turnover are controlled). The fact that most likely the two halves of protein turnover, synthesis and breakdown, are separated spatially and the mechanisms involved are different further emphasizes the complexity of macromolecular turnover. 'Turnover' is used in a different context when the turnover of a cycle is discussed; but here again a number of complex metabolic reactions have to be interrelated and controlled; some such cycles are discussed briefly in this volume, additional cycles have been discussed with metabolism, and some cycles still await elucidation or discovery. 480 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Neurochemistry, having the objective of elucidating biochemical processes subserving nervous activity, emerged as an application of chemistry to the of neurobiological problems as a post-World War II phenomenon. investigation However, only in the last 40 years has the chemical community recognized neurochemistry as a distinct, if hybrid, discipline. During this period great strides have been made. However, recently neurochemistry, along with neu rophysiology, neuropharmacology, neuroanatomy, and the behavioral sci ences, has emerged to form neuroscience, a new community of scientists with its own national society, journals, and meetings. Actually, this recently formed hybrid, neuroscience, is in the process of merging with another well-established discipline, molecular genetics (frequently called molecular biology, and itself a hybrid), which appears to have sufficient hybrid vigor to form yet a new community of scientists, which, for want of a more imaginative term, has been called molecular genetic neuroscience. Clearly, advantages resulting from such mergers or hybridizations accrue not only from the merging discipline (neurochemistry in this case) to the new community (molecular genetic neuroscience), but also in the reverse direction. This Foreword will be concerned primarily with examples of this latter process. 736 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Two central ideas in the movement toward advanced automation systems are the office-of-the-future (or office automation system), and the factory of-the-future (or factory automation system). An office automation system is an integrated system with diversified office equipment, communication devices, intelligent terminals, intelligent copiers, etc., for providing information management and control in a dis tributed office environment. A factory automation system is also an inte grated system with programmable machine tools, robots, and other pro cess equipment such as new 'peripherals,' for providing manufacturing information management and control. Such advanced automation systems can be regarded as the response to the demand for greater variety, greater flexibility, customized designs, rapid response, and 'Just-in-time' delivery of office services or manufac tured goods. The economy of scope, which allows the production of a vari ety of similar products in random order, gradually replaces the economy of scale derived from overall volume of operations. In other words, we are gradually switching from the production of large volumes of standard products to systems for the production of a wide variety of similar products in small batches. This is the phenomenon of 'demassification' of the marketplace, as described by Alvin Toffier in The Third Wave. 544 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The content of Volume 8 of the Handbook of Neurochemistry is a perfect example and sample of what occupies neurochemists in the late 1980s. What occupies them are questions, concepts, and technology that either did not start with the nervous system, or rapidly moved out of its exclusivity (see, for in stance, chapters on neurotensin, beta-lipotropin, behavioral and neurochemical effects of ACTH, cholecystokinin, etc.). Thus, the neurochemist is more and more seen as a biochemist occupied by questions, concepts, and technology that are not unique to the nervous system, even though the ultimate substrate of these questions, as well as the ultimate functions so studied and occasionally explained, are of the nervous system. Look at the case of the hypothalamic hypophysiotropic peptides, also called hypothalamic releasing factors, or hypothalamic releasing hormones. These are all small-to-medium-size polypeptides originally characterized in ex tracts of the hypothalamus on the basis of bioassays directed at studying their effects on one or another of the secretions of the adenohypophysis. We know now that TRFs (See Chapter 8), the thyrotropin and prolactin releasing factor, somatostatin, the hypothalamic inhibitor of the secretion of growth hormone, as well as LRF, the hypothalamic decapeptide stimulating the secretion of pituitary gonadotropins, are to be found in parts of the brain other than the hypothalamus, where their function is obviously not hypophysiotropic. Such is also the case for CRF-the corticotropin and beta-endorphin releasing factor. 704 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -(Written for the original Russian edition) Out of all the functional groups of protein molecules that be long to the side chains of amino acid residues, the sulfhydryl or thiol (SH) groups of cysteine residues and the disulfide (S-S) groups of cystine have for long attracted particular attention from chemists and biochemists. This is due, on the one hand, to the high chemical reactivity of these groups, which enter into many, and often very characteristic and selective, reactions with several types of compound. On the other hand, this attention is connected with the great significance of SH and S-S groups for the specific functions of a number of enzymes, hormones, and other biological ly active proteins, and consequently for the normal course of many physiological processes. The varied functions of sulfhydryl and disulfide groups in en zymes are particularly interesting; their role can consist of bind ing substrates and cofactors, in direct participation in the catalytic act, or in maintaining (in ways not so far sufficiently studied) the native, catalytically active conformation of the protein. It is entirely natural that the detailed study of the chemical behavior and biological role of these sulfur-containing groups in proteins (and in such low-molecular cofactors as glutathione, co enzyme A, lipoiC acid, etc. ) has, in addition to its academic, gen eral biological interest, great Significance for many applied branches of medicine and biology (toxicology, radiobiology, diagnostics and therapeutics, biochemical engineering, plant growing, etc. ). 288 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -How to produce images with sound has intrigued engineers and scientists for many years. Bats, whales and dolphins can easily get good mental images with acoustical energy, but humans have little natural ability for obtaining such images. The history of engineering and science, however, is an impressive demonstration that technological solutions can compensate, and then some, for deficiencies of nature in humans. Thus with the proper technology, we too can 'see' with sound. Many methods involv ing ultrasonic energy can be employed to enable us to do so. Few of these methods are at all reminiscent of the acoustic systems employed by animals. Pulse-echo, phase-amplitude and amplitude-mapping approaches constitute the conceptual bases for three fundamentally different types of acoustic imaging systems and can be used for categorizing the systems. However, by now systems exist that combine the approaches in such sophisticated ways as to make an unambiguous categorization of some of the more complicated systems difficult or impossible. Among the instruments so far pro duced are mechanically-scanning focused instruments, chirped pulse-echo instruments, and instruments involving holography, tomography, parametric excitation, phase conju gation, neural networks, random phase transduction, finite element methods, Doppler frequency shifting, pseudo inversion, Bragg diffraction and reflection, and a host of other principles. The fifty-five chapters in this volume are selected from papers presented at the Eighteenth International Symposium on Acoustical Imaging which was held in Santa Barbara, California on September 18 - 20, 1989. 572 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In August 1978 a group of 80 physicists from 51 laboratories of 15 countries met in Erice to attend the 16th Course of the International School of Subnuclear Physics. The countries represented at the School were: Austria, Denmark, Federal Republic of Germany, Finland, France, Israel, Italy, the Netherlands, Sweden, Switzerland, South Africa, Turkey, the United Kingdom, The United States of America, and Yugoslavia. The School was sponsored by the Italian Ministry of Public Education (MPI) , the Italian Ministry of Scientific and Technological Research (MRSI) , the North Atlantic Treaty Organization (NATO), the Sicilian Regional Government, and the Weizmann Institute of Science. As usual, the Course was devoted to a review of the most out standing problems and results in Subnuclear Physics, with particular emphasis on the new aspects; there were mainly two: supersymmetry and electroweak interactions. In his famous lecture at Erice in 1967, Sid Coleman reviewed 'All possible symmetries of the S matrix. ' All but one, namely that which tells you: if you have a fermion you must have a boson. This is super symmetry , and this produces the superspace, i. e. an entity which has not only the Einstein-'bosonic' coordinates, but also 'fermionic' coordinates. From superspace we get supergravity; and this means that one day we should be able to detect not only the graviton (with spin 2) but also the gravitino (spin 3/2). If we add 'flavour', 'colour', and 'family' as other intrinsic degrees of freedom, we get extended supergravity. 816 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The purpose of this book is to present computationally efficient algorithms for calculating the dynamics of robot mechanisms represented as systems of rigid bodies. The efficiency is achieved by the use of recursive formulations of the equations of motion, i.e. formulations in which the equations of motion are expressed implicitly in terms of recurrence relations between the quantities describing the system. The use of recursive formulations in dynamics is fairly new, 50 the principles of their operation and reasons for their efficiency are explained. Three main algorithms are described: the recursIve Newton-Euler formulation for inverse dynamics (the calculation of the forces given the accelerations), and the composite-rigid-body and articulated-body methods for forward dynamics (the calculation of the accelerations given the forces). These algorithms are initially described in terms of an un-branched, open loop kinematic chain -- a typical serial robot mechanism. This is done to keep the descriptions of the algorithms simple, and is in line with descriptions appearing in the literature. Once the basic algorithms have been introduced, the restrictions on the mechanism are lifted and the algorithms are extended to cope with kinematic trees and loops, and general constraints at the joints. The problem of simulating the effect of contact between a robot and its environment is also considered. Some consideration is given to the details and practical problems of implementing these algori hms on a computer. 224 pp. Englisch.