springer us jul 2012 (176 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware - In July 1979, the Faculty of Pharmacy of the University of Bologna received a proposal from Professor Breccia to hold an International Conference on 'Nitroimidazoles: Chemistry, Pharmacology and Clinical Application'. Because of the great interest in these drugs in various fields, I was very pleased to accept the proposal and to give to the Conference, the sponsorship of the University of Bologna. It was an added pleasure to accept the chairmanship of the meeting, together with Professors Sensi and Adams. At the same time, the Minister of Education approved the proposal also from the Faculty of Pharmacy, to offer an advanced Course on the tOpic: 'Radiosensitizers of Hypoxic Cells'. This Course was subsequently approved by a special Committee of the NATO Scientific Programme as an Advanced Study Institute. Since the subject matter of both the Conference and the Course are closely inter-related, it was logical to plan the Conference as part of the overall Course. Bringing together specialists from quite different and apparently unrelated fields of research, but all with an interest in the study and application of one single group of drugs, is a novel idea with intriguing possibilities. The volumes of the proceedings include contributions from experts with such diverse interests as synthetic chemistry, mechanism of drug action, parasitology, anaerobic bacteria and protozoa, pharmacology and toxicology, radiation sensitizers for use in radiotherapy and the development of drugs for use in cancer chemotherapy generally.

Taschenbuch. Zustand: Neu. Neuware - Naturally occurring antinutrients and food toxicants, and those formed during food processing, adversely affect the nutri tional quality and safety of foods. Because of the need to improve food quality and safety by plant breeding, fortification with appropriate nutrients, and processing methods, and because of the growing concern about possible direct relationships between diet and diseases, research is needed to: (1) evaluate the nutritive quality and safety of crops and fortified, supplemented, and processed foods; (2) define conditions that favor or minimize the formation of nutritionally antagonistic and toxic compounds in foods; and (3) define the toxicology, metabolism, and mechanisms of the action of food ingredients and their metabolites. As scientists interested in improving the safety of the food supply, we are challenged to respond to the general need for exploring: (1) possible adverse consequences of antinutrients and food toxicants; and (2) factors which contribute to the formation and inactivation of undesirable compounds in foods. Medical research offers an excellent analogy. Studies on causes and mechanisms of disease processes are nearly always accompanied by parallel studies on preventive measures and cures. Such an approach offers the greatest possible benefits to the public.

Taschenbuch. Zustand: Neu. Neuware - Even though artificial insemination is a simple technique that has been practiced for over a century, it has long been carried out under poor conditions due to an inadequate understanding of repro ductive physiology and antagonistic socio-ethical attitudes. Accor dingly, until fairly recently it was a medical act with a limited scientific basis which was practised more or less clandestinely. The development of semen preservation has totally changed the conditions of artificial insemination, especially in regard to flexibility and safeguards in its application. Although the use of fresh semen continues, it is now clear that the future of arti ficial insemination is closely linked to semen preservation. During the past two decades, semen banks have been developed in many countries. This has most often been the result of the initiative of individual physicians in either the private or public sectors. In France, a national system of semen banks (CECOS) was begun in 1973. Although there has been cooperation within this system in the areas of both research and management, a need to com municate and compare experiences with those from other countries was perceived. Thus, the first International Symposium on Artifi cial Insemination and Semen Preservation was planned and held in Paris, France in April 1979. Thirty-seven countries were represented byihdividuals from many concerned disciplines.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Recently, there has been a considerable upsurge of interest in heavily doped semiconductors. This interest is due primarily to the expanding range of applications of such. materials. Moreover, the heavy doping of semiconductors produces new effects (the forma tion of impurity aggregates, the appearance of allowed states in the forbidden band, etc J, which are of great interest in solid-state physics. The rapid growth in the number of papers on heavily doped semiconductors makes it difficult to review the results obtained so far. Therefore, many investigations carried out in 1966-7, par ticularly those on AIIIBV semiconductors, are not discussed in the present monograph, which represents the state of the knowledge in 1965. Nevertheless, the author hopes that, in spite of this, the book will be useful. An attempt is made, first, to review investigations of heavily doped semiconductors from a certain viewpoint and, sec ondly, to suggest some ideas (Chap. 5) which may be controversial but which are intended to stimulate further studies of heavily doped semiconductors which can be regarded as a special case of dis ordered systems. The work of American scientists investigating heavily doped semiconductors, in particular the efforts of E. O. Kane, J. 1. Pan kove, R. N. Hall, R. A. Logan, W. G. Spitzer, F. A. Trumbore, and many others, is well known to Soviet investigators. It gives me pleasure to learn that Western readers will now have an - v vi PREFACE portunity to become acquainted with the work done in the USSR. 436 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Mankind, throughout history, has strived to improve his food sources. By means of slow and empirical selections, it has been possible to greatly increase both quantity and quality of plant crops. This procedure has brought the most useful cereals to a state of refinement that seems to be difficult to further improve by the same methodology. Indeed, natural sexual mechanisms were always used to cross closely related sexually and genetically compatible organisms; the selection procedure consisted of isolating the most promi sing progenies. Obviously, by this way, plants could only share preexisting genetic pools. On the other hand, the last decade has seen drastic modifi cations of the experimental plant sciences, with the appearance of new technological possibilities. Because of this profound reshaping of our experimental ap proaches, other means can now be realistically envisaged in order to achieve similar or even higher goals. It is, for instance, possible to attempt completing sexual crosses (where both male and female gametes bring together the genetic informations necessary for growth and development of the offspring) by parasexual means by which novel genetic informa tions could possibly be added to the heritage -. At the limit, such genetic manipulations could enable man to create plants capable of producing new substances characteris tic of unrelated plants or, more generally, of other living or ganisms. Even if these possibilities might appear quite remote, the interest of Scientists has been awaken and, indeed, several at tempts to such genetic manipulations have already been made. 620 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Although the history of photomedicine dates back thousands of years, with even preliterate cultures appreciating the healing properties of sunlight, for many workers in the discipline photomedicine is associated with the observation about 100 years ago of Niels Finsen, a Danish physician. Finsen recognized that people with tuberculosis who lived in Norway and who had very little exposure to sunlight often developed facial lesions (lupus vulgaris) which would decrease and sometimes disappear during the summer months. This very observant physician reasoned that artificial light ought to produce the same effect as sunlight and began utilizing the radiation from the newly available carbon arc. At first, he used a glass lens to concentrate the radiation, but since this produced considerable burning, he replaced this with a hollow glass lens filled with water. However, while this reduced the heat burns, it did not actually duplicate the effect of direct sunlight. Finally, using a hollow lens filled with water but equipped with quartz windows, Finsen was able to imitate, even improve upon, the effect of sunlight. As a result, lupus vulgaris was practically eliminated from the Scandinavian countries. 688 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is a sequel to our 1996 compilation, Computational and Constructive Design Theory. Again we concentrate on two closely re lated aspects of the study of combinatorial designs: design construction and computer-aided study of designs. There are at least three classes of constructive problems in design theory. The first type of problem is the construction of a specific design. This might arise because that one particular case is an exception to a general rule, the last remaining case of a problem, or the smallest unknown case. A good example is the proof that there is no projective plane of parameter 10. In that case the computations involved were not different in kind from those which have been done by human brains without electronic assistance; they were merely longer. Computers have also been useful in the study of combinatorial spec trum problems: if a class of design has certain parameters, what is the set of values that the parameters can realize In many cases, there is a recursive construction, so that the existence of a small number of 'starter' designs leads to the construction of infinite classes of designs, and computers have proven very useful in finding 'starter' designs. 384 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With the development in recent years of NMR spectrometers capable of recording with a minimum of effort data that are both accurate and reproducible, a need has arisen for spectra catalogs and data books to aid the researcher. The ability to correlate a spectrum to a precalibrated chart accurately (to within 0. 02 ppm) has made chemical shift, along with the character of the spectral lines produced, an increasingly important tool in configurational analysis-a tool which this book is designed to complement. It is known that the chemical shift of a proton can be influenced by atoms as much as five or six carbons away, a fact of great importance to compound identification. The entries in this book, arranged according to proton environment, enable the researcher with a hypo thetical structure already proposed for his unknown quickly to locate examples of compounds having similar structures. An index of molecular formulas and a shift index, which should prove useful in hypothesizing alternate structures for the unknown and in checking out the hypotheses, have also been provided. The data collected represent some 4800 shifts from the spectra of about 1200 compounds that appear in the catalogs of Varian Associates, Sadtler Research Laboratories, and the American Petroleum Institute, whose cooperation is gratefully acknowledged. The alphanumerical code that is the basis of our presentation, and the explanation of its use, are borrowed intact from the NMR Spectra Catalog of Varian Associates, for whose permission to use this material we are especially grateful. 452 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Dr. V. V. Ol'shevskii is perhaps most familiar to Western readers as the author of 'Characteristics of Sea Reverberation,' published in translation by Consultants Bureau (New York, 1967). The present book, 'Statistical Methods in Sonar,' is, in part, a sequel to the first book, where now the author's stated purpose is 'to acquaint a broad range of specialists with the use of contemporary statistical methods for solving theoretical and applied sonar problems. ' As the author quite properly observes, the work is illustrative, devoted to a variety of relevant, specific technical problems from an analytical point of view, and is not in any way intended to be an all-inclusive treatise. Nevertheless, as the reader can verify subse quently, the author has succeeded in accomplishing his stated purpose. He has, moreover. provided us with a use ful and, in a number of instances, provocative work, which even five years after its original appearance retains its freshness and interest with material not to date covered in other books on the subject (for example, see Horton [~Q], Stephens [41] ). \* In this Foreword we first concisely review the author's material, on a chapter-by-chapter basis, after which a short general critique is given. Attention is called to various topics of particular interest to the professional audience. as well as to a number of highlights which deserve the reader's notice (a few additional comments on the technical editing are then included). 264 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -RajB KNRao Conference Director, Birmingham Polytechnic Condition Monitoring and Diagnostic Engineering Management (COMADEM) is a relatively new field that has already made its mark in a wide range of industries. But all the signs are that even more will be required of researchers in the field over the next decade, for COMADEM directly addresses a whole range of issues that are likely to become increasingly important to companies as competitiveness increases along with the uncertainties resulting from rapid technological change. Already for example, businesses are having to scrutinize the economics of plant and machinery in greater detail than ever before; reliability is becoming a crucial factor as the costs of unscheduled breakdowns rise and there is increasing pressure on companies to demonstrate and assure improved health and safety conditions, especially in light of the growing number of catastrophic accidents that have occured throughout the world. Because it offers solutions to these and similar problems, COMADEM is now gaining an international reputation as a problem-solving, user-friendly and financially beneficial multi-discipline with immense potential. Many people at the senior management level are now convinced that COMADEM has much to offer and are wasting no time in reaping maximum benefit from the latest developments. The fact that the first UK informal seminar on COMADEM - COMADEM 88 - proved to be a great success and had a truly international flavour reflected this growing interest in the new field. 564 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In recent years psychology has considerably expanded and en riched its relations with medical practice, first and foremost with psychiatry. This orientation toward experimental abnormal psy chology has been closely tied to the practical tasks of psychiatry: differential diagnosis, establishment of the structure and extent of impairment, and the dynamics of mental disorders as affected by treatment, etc. Experimental abnormal psychology has been no less important for the theoretical problems of psychology and psychiatry. The study of pathological changes in mental processes helps in dealing with questions about the structure and formation of mental activity. The research findings of abnormal psychology also have important implications for overcoming biologizing tendencies in the interpre tation of human psychology. The present book does not try to provide an exhaustive expo sition of all divisions of abnormal psychology. It introduces the reader only to those problems which at the present time seem to be best worked out experimentally: the breakdown of intellectual capacity, thought disorders, the methodology of setting up an ex periment in the psychiatric clinic, and certain questions relating to motivational disturbances and psychological growth and decay. Some rewritten sections from the author's earlier book, 'The Pathology of Thinking,' have been included. v vi FOREWORD The present volume is intended for psychology students, for psycholOgists, and for physicians working in psychiatry. 172 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Among seismic waves generated by widely dilferent types of sources, the waves that are the most interest ing and of the longest duration are usually surface waves (which are also called normal waves, interference and channel waves, natural vibrations of layers, etc. ). These waves are distinguished by their dispersion and reso nance, and are used in many investigations - in the determination of the structure of the medium (the existence of surface layers and waveguides), in the determination of the coordinates and properties of the source (in par ticular its energy and mechanism), in the identification of subterranean exploSions, in the mapping of micro- seisms, in the tracing of storms, etc. Outlines of the wide literature concerning surface waves can be found in [2, 9, 40J. Surface waves can be classed as Rayleigh or Love waves, depending on their velocity and polarization: the displacements of particles in Rayleigh waves are parallel, and the displacements in Love waves perpendicular, to the vertical plane containing the direction of propagation (some variation from this polarization is possible close to the source or in the presence of horizontal inhomogeneities in the medium). The present work is devoted to the calculation and investigation of Love waves in a vertically layered medium. The method used is based on the spectral theory of linear differential operators. ' This method is much more effective than previously applied methods based on the approximation of the medium by a set of homogeneous layers. 108 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is the proceedings of a Symposium entitled 'The Physics of Solid-Solution Strengthening in Alloys' which was held at McCormick Place, Chicago, on October 2, 1973, in association with a joint meeting of the American Society for Metals (ASM) and The Metallurgical Society (TMS) of the American Institute of Mining, Metallurgical, and Petroleum Engineers (AIME). The symposium, which was initiated and organized by the editors of this volume, was sponsored by the Committee on Alloy Phases, Institute of Metals Division, TMS, AIME, and the Flow and Fracture Section of the Materials Science Division, ASM. The discipline of Alloy Design has been very active in recent years, during which considerable stress has been placed on the roles of crystallography and microstructure in the rationalization and prediction of properties. Underestimated as a component of alloy design, however, has been the importance of physical property studies, even though physical property measurements have tradi tionally been employed to augment direct or x-ray observations in the determination of phase equilibrium (and, indeed, metastable equilibrium) boundaries. 320 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Conference on Nuclear Masses and their Determination which was held at the Max Planck I nstitute in Mainz from 10 to 12 July 1956 resulted in the formation by the International Union of Pure and Applied Physics of a Commission on Atomic Masses and Related Constants. Under the auspices of this Commission conferences covering these subjects were held in Hamilton, Ontario (12-16 September, 1960), in Vienna (15-19 July 1963) and in Winnipeg (28 August-1 September 1967). After the last of these conferences the Commission felt that the position regarding nuclear masses was reasonably good and that as a consequence the fundamental constants should get more emphasis in future conferences. For this reason they were very pleased to accept an offer from the National Physical Laboratory to accept the main burden of organizing the Fourth International Conference on Atomic Masses and Fundamental Constants. An Organizing Committee was appointed with the members: J. H. Sanders, Chairman B. W. Petley, Secretary A. Horsfield, Treasurer P. Dean A. H. Wapstra. They were assisted by a Program Committee consisting of: A. H. Wapstra, Chairman E. R. Cohen A. Horsfield W. H. Johnson, Jr. J. H. Sanders J. Terrien. 592 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume serves as a general introduction to the state of the art of quantitatively characterizing chaotic and turbulent behavior. It is the outgrowth of an international workshop on 'Quantitative Measures of Dynamical Complexity and Chaos' held at Bryn Mawr College, June 22-24, 1989. The workshop was co-sponsored by the Naval Air Development Center in Warminster, PA and by the NATO Scientific Affairs Programme through its special program on Chaos and Complexity. Meetings on this subject have occurred regularly since the NATO workshop held in June 1983 at Haverford College only two kilometers distant from the site of this latest in the series. At that first meeting, organized by J. Gollub and H. Swinney, quantitative tests for nonlinear dynamics and chaotic behavior were debated and promoted [1). In the six years since, the methods for dimension, entropy and Lyapunov exponent calculations have been applied in many disciplines and the procedures have been refined. Since then it has been necessary to demonstrate quantitatively that a signal is chaotic rather than it being acceptable to observe that 'it looks chaotic'. Other related meetings have included the Pecos River Ranch meeting in September 1985 of G. Mayer Kress [2) and the reflective and forward looking gathering near Jerusalem organized by M. Shapiro and I. Procaccia in December 1986 [3). This meeting was proof that interest in measuring chaotic and turbulent signals is widespread. 488 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the book are reported the main results presented at the Third International Workshop on Data Analysis in Astronomy, held at the EUore Majorana Center for Scientific Culture, Erice, Sicily, Italy, on June 20-27,1988. The Workshop was the natural evolution of the two previous ones. The main goal of the first edition (Erice 1984) was to start a scientific interaction between Astronomers and Computer Scientists. Aim of the second (Erice 1986) was to look at the progress in data analysis methods and dedicated hardware technology. Data analysis problems become harder whenever the data are poor in statistics or the signal is weak and embedded in structured background. Experiments collecting data of such a nature require new and non-standard methodologies. Possibilistic approaches could be merged with the statistical ones, in order to formalize all the knowledge used by the scientists to reach conclusions. Moreover, the last decade has been characterized by very fast developments of Intelligent Systems for data analysis (knowledge based systems, . ) that would be useful to support astronomers in complex decision making. For these reasons, the last edition of the workshop was intended to provide an overview on the state of the art in the data analysis methodologies and tools in the new frontieres of the astrophysics (y-astronomy, neutrino astronomy, gravitational waves, background radiation and extreme cosmic ray energy spectrum). The book is organized in two sections: - Data analysis methods and tools, - New frontieres in astronomy. 428 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Advances in Cell Biology has been initiated as a continuing, multi-volume series to report on the progress of a wide spectrum of problems of cell structure and cell func tion. In arranging these volumes individual contributors are asked not only to review the major new information, but especially to present the state of a given problem or area by discussing the current central issues, speculations, concepts, hypotheses, and technical problems. We intend, in addition, that these volumes will not be concerned with comprehensive reviews of the recent literature but will consist rather of presenta tions of an interpretative and integrative nature, based on selection of major research advances. It is our aim that these volumes should provide the means whereby cell biologists may keep themselves reasonably well informed about the current progress in research areas in cell biology in which they are not immediately or directly involved themselves. The articles, nevertheless, are expected to bring into focus the experimental objectives of the specialists in a given research area. D.M.P. L. G. E. M. vii Contents v Contributors Preface vii Bacterial Chromosome Replication 3 I. Peter L. Kuempel 57 2. Structure and Replication of Eukaryotic Chromosomes David M. Prescott Ultrastructure and Interaction of the Kinetochore and Centriole 3. 352 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Advanced Study Institute (ASI) on Nonlinear Phenomena-in Physics and Biology was held at the Banff Centre, Banff, Alberta, Canada, from 17 - 29 August, 1980. The Institute was made possible through funding by the North Atlantic Treaty Organization (who sup plied the major portion of the financial aid), the National Research and Engineering Council of Canada, and Simon Fraser University. The availability of the Banff Centre was made possible through the co sponsorship (with NATO) of the ASI by the Canadian Association of Physicists. 12 invited lecturers and 82 other participants attended the Institute. Except for two lectures on nonlinear waves by Norman Zabusky, which were omitted because it was felt that they already had been exhaustively treated in the available literature, this volume contains the entire text of the invited lectures. In addition, short reports on some of the contributed talks have also been included. The rationale for the ASI and this resulting volume was that many of the hardest problems and most interesting phenomena being studied by scientists today ar.e nonlinear in nature. The nonlinear models involved often span several different disciplines, °a simple example being the Volterra-type model in population dynamics which has its analogue in nonlinear optics and plasma physics (the 3-wave problem), in the discussion of the social behavior of animals, and in biological competition and selection at the molecular level. 624 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -These volumes contain the invited and contributed talks of the first general Conference of the Condensed Matter Division of the European Physical Society, which took place at the campus of the University of Antwerpen (Universitaire Instelling Antwerpen) from April 9 till 11, 1980. The invited talks give a broad perspective of the current state in Europe of research in condensed matter physics. New developments and advances in experiments as well as theory are reported for 28 topics. Some of these developments, such as the recent stabilization of mono-atomic hydrogen, with the challenging prospect of Bose condensation, can be considered as major break throughs in condensed matter physics. Of the 65 invited lecturers, 54 have submitted a manuscript. The remaining talks are published as abstracts. The contents of this first volume consists of 9 plenary papers. Among the topics treated in these papers are: - electronic structure computations of iron the density functional theory hydrogen in amorphous Si topologically disordered materials nuclear antiferromagnetism stabilization of mono-atomic hydrogen gas covalent and metallic glasses nonlinear excitations in ferroelectrics. 496 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The fourth course of the International School of Physics of Exotic Atoms took place at the 'Ettore Majorana' Center for Scien tific Culture, Erice, from March 31 to April 6, 1984. As tradition, exotic atoms have been a tool for studying elec tromagnetic, weak and strong interactions at low energies. We felt it appropriate to have a full course devoted to a discussion of the information to be gained on the fundamental interactions from the study of low energy systems. In this kind of physics, which is characterized experimentally by very intense particle sources and very sensitive apparatuses, one can search for rare events and can perform precise measurements. Sensitive tests of the predictions of current theories of electro weak and strong interactions can thus be achieved. The course was attended by 54 participants from 23 institutes in 9 countries. The morning lectures reviewed the achievements of the field in the last few years and the afternoon seminars dealt with new results and projects. 516 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During the last 30 years our knowledge and understanding of molecular processes has followed the development of increasingly sophisticated tech niques for studying fast reactions. Although the results are reported in papers and reviews, it is sometimes difficult for those not themselves active in these fields to find their way through the mass of published material. We hope that each book in this series will present a clear account of the present state of knowledge in a particular field of physical chemistry to research workers in related fields, to research students, and for the preparation of undergraduate and post-graduate lectures. Each chapter describes the theoretical develop ment of one area of study and the appropriate experimental techniques; the results presented are chosen to illustrate the theory rather than to attempt a comprehensive review. The first volume published in 1972 was concerned with the reactions of small molecules and free radicals in the gas phase. The development of flash photolysis in the 1950s paved the way by making it possible to generate free radicals in sufficient concentration for a spectroscopic' snapshot' to reveal their molecular structure. Their role in kinetic systems could then be followed directly, rather than be inferred from mechanism. The shock tube enabled gas mixtures to be heated to any desired temperature in a time which was shorter than subsequent chemical reactions. Discharge-flow methods enabled the reactions of atoms and free radicals to be studied directly. 296 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During the past three decades, the cerebral vasculature and its role in blood-brain transport has been an increasingly active area of investigation and learning, particularly from an anatomical and physiological point of view. However, much less is known at the molecular and cellular level about the blood-brain barrier especially regarding the macromolecules responsible for transport, the roles played by vascular wall components (endothelial cell, pericyte, smooth muscle, basement membrane), and the mechanisms regulating brain vascular-specific protein expression and their molecular alterations during development and disease. Fundamental questions still unanswered include: What are the molecular constituents of brain endothelial cell tight junctions What are the membrane proteins responsible for transport of specific substrates What are the molecular signals that cause glucose transporter gene expression to be 20 to 100 times greater in brain endothelial cells in vivo than in vitro What roles do pericytes, smooth muscle cells and basement membrane have in establishing or maintaining blood-brain transport characteristics Are brain vascular transport systems responsible for edema following injury Are transporter systems regulated via receptor-mediated events Do hormones or neuromodulators regulate transporter expression What is the molecular mechanism by which plasma proteins enter the extravascular space Are transporters asymmetrically distributed between the luminal and abluminal endothelial cell membranes Can prodrugs or pharmacologic agents be designed as substrate analogs and be delivered to the central nervous system via existing transporters or receptors Can new and beneficial transporters be introduced into the brain vasculature 308 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'People . . . see you sweat in agony, turn pale, turn red, trem ble, vomit your very blood, suffer strange contractions and con vulsions, sometimes shed great tears from your eyes, discharge thick, black and frightful urine, or have it stopped up by some sharp rough stone that cruelly pricks and flays the neck of your penis. ' \* These 16th century frustrations of Michel de Montaigne which most graphically reflect his experience with renal colic still plague approximately 1 per 1000 individuals in the United States annually. Since as many as 75% of clinically. apparent episodes of renal colic represent single nonrecurring events, physicians not in frequently approach the differential diagnosis of nephrolithiasis in a less than adequate fashion and assume that the incident may prob ably never recur after the single attack. However, the ureteral or bladder stone actually represents one form of abnormal crystalline precipitation; parenchymal nephrocalcinosis, silently progressive azotemia, and asymptomatic renal pelvic calculi may also stem from the same pathological process(es) which conditioned the for mation of the ureteral or bladder stone. In this regard it is worth emphasizing that the postmortem incidence of renal calculi is some tenfold greater than that presumed from surveys wherein a clinical attack of nephrolithiasis is the sole determinant. \*In Familiar Medical Quotations. M. B. Strauss, Ed. Little Brown, Boston, 1968, p. 646. v vi FOREWORD The last decade has witnessed the birth of new knowledge in urolithiasis research. 176 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In alternating years, the Denver X-ray Conference turns its principal attention, through the choice of subjects for the plenary lectures, to various aspects of either X-ray fluorescence or dif fraction. This is a 'fluorescence' year, and the three invited lecturers are experts in techniques that are at, or perhaps yet a bit beyond, the forefront of our understanding and technology in that field. The common denominator in selecting these subjects was that each is approaching a full elucidation of theory, and active develop ment of practical hardware, and that each presents analytical pos sibilities which can hardly be ignored in the next generation of commercial instrumentation. In other words, these are techniques that many of us shall likely find ourselves using by the end of the decade. The greatest difficulty in selecting the subjects was the need to overlook others, particularly 1) the increasing inter est in 'in-situ' or on-line analytical control, for tagging, identi fication or sorting; and 2) the broad subject of the computeriza tion of instrumentation, with its powerful impact on the design of hardware, and its open invitation to the theorist to create more exact mathematical models of the analytical process, regardless of complexity, in the expectation that programmers will find ways to implement solutions in affordable, dedicated computers. 420 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Apparatus for Recording Neutral Particles by Reference to Decay Gamma Quanta.- Magnetic Spectrometer for Charged Particles.- Experimental Method of Determining the Efficiency Function of an Apparatus Containing a Magnetic Spectrometer.- Positive Pion Stopping Detector.- Absolute Sensitivity of a Thick-Walled Graphite Ionization Chamber for 1-GeV Photons.- Statistics of Time Measurements Made by the Scintillation Method.- A Cathode Stage with Amplified Feedback and Its Applications.- Wilson Chamber for Studying Photomeson Processes.- Relative Monitor for a Wilson Chamber. 196 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -- One volume-reference work with approximately 250 entries, organized alphabetically for ease of use and of locating subject matter. Each entry will contain 5-8 references as well as a bibliography of references and suggested readings- An authoritative reference text on school psychology that would appeal to, and be understood by, a broad audience.- Will assist individuals in acquiring a general understanding of some of the theories, practices, and language associated with the field of school psychology 404 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -For many years ergonomists and human engineering specialists have made significant contributions to the solution of problems faced in the area of human labour and to the introduction of their research results and field experience into the process of equipment design. However, the rapid increase in complexity of equipment in use as well as in development demonstrates the necessity of broaden ing the point of view continuously. The workshop held in Munich from March 22nd to March 26th, 1982, was an excellent opportunity for the participants to discuss their respective interests and their interpretation of needs for future research. The workshop was sponsored by the Human Factors Special Programme Panel of the Scientific Affairs Division of NATO. This sponsorship, together with the helpful assistance rendered by Drs. Bayraktar, Kroemer, and Sanders, is gratefully acknowledged. This volume contains the papers presented during the workshop. All these papers are directly related to the general aim: the ex change of experience collected in the field of ergonomic data for equipment design on the one hand and the definition of unexplored areas on the other. It is hoped that this presentation will help to define future research methods in the area of ergonomic data and set into motion fruitful discussions on the validity of the data in use today. 296 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The 1976 Cargese Summer Institute was devoted to the study of certain exciting developments in quantum field theory and critical phenomena. Its genesis occurred in 1974 as an outgrowth of many scientific discussions amongst the undersigned, who decided to form a scientific committee for the organization of the school. On the one hand, various workers in quantum field theory were continuing to make startling progress in different directions. On the other hand, many new problems were arising from these various domains. Thus we feIt that 1976 might be an appropriate occasion both to review recent developments and to encourage interactions between researchers from different backgrounds working on a common set of unsolved problems. An important aspect of the school, as it took place, was the participation of and stimulating interaction between such a broad spectrum of theorists. The central topics of the school were chosen from the areas of solitons, phase transitions, critical behavior, the renormalization group, gauge fields and the analysis of nonrenormalizable field theories. A noteworthy feature of these topics is the interpene tration of ideas from quantum field theory and statistical mechanics whose inherent unity is seen in the functional integral formulation of quantum field theory. The actual lectures were partly in the form of tutorials designed to familiarize the participants with re cent progress on the main topics of the school. Others were in the form of more specialized seminars reporting on recent research. 488 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The 52nd Colloid and Surface Science Symposium of the Divis ion of Colloid and Surface Chemistry of the American Chemical Society was held in Knoxville, TN, June 12-14, 1978, and one of its Sections was devoted to the topic of Solution Chemistry of Surfactants. Although it was billed as the Section on Solution Chemistry of Surfactants, but it was indeed a veritable inter national symposium on this topic as 51 papers by about 100 con tributors from 12 countries were listed in the program. The present volume and its companion volume 2 document the proceedings of the above-mentioned Section on Solution Chemistry of Surfactants. In 1976 there was held an international symposium on Micellization, Solubilization and Microemulsions in Albany, l the proceedings of which have been chronicled in two volumes. A great deal of material dealing with micelles contributed by a legion of prominent researchers constitutes these volumes but a few subtopics were not adequately covered; so it was deemed appro priate to cover these topics as well as the recent progress in the general area of aggregation of surfactants in this Section. Also as it is the amphiphilicity or amphipathicity\* of a surfact ant molecule which is responsible for both adsorption at inter faces and aggregation in solution, so it was considered quite apropos to include the topic of adsorption at interfaces in this Section. Concomitantly, the present volumes not only cover the aggregation phenomena but also the adsorption at interfaces. 548 pp. Englisch.