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Buch. Zustand: Neu. Neuware -Many scientific papers and popular articles have been written on the topic of space tourism, describing everything from expected market sizes to the rules of 3-dimensional microgravity football. But what would it actually feel like to be a tourist in space, to be hurled into orbit on top of a controlled explosion, to float around in a spacecraft, and to be able to look down on your hometown from above the atmosphere Space tourism is not science fiction anymore, Michel van Pelt tells us, but merely a logical step in the evolution of space flight. Space is about to be opened up to more and more people, and the drive behind this is one of the most powerful economic forces: tourism. Van Pelt describes what recreational space travel might look like, and explains the required space technology, the medical issues, astronaut training, and the possibilities of holidays to destinations far, far away.This is a book for everyone who has ever dreamed of traveling to space: a dream which, according to van Pelt, may not be so far from becoming a reality.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 240 pp. Englisch.

Buch. Zustand: Neu. Neuware -Preface to the sixth edition x 1 THE DEVELOPMENT OF ANTIMICROBIAL AGENTS, PAST, PRESENT AND FUTURE 1 1. 1 The social and economic importance of antimicrobial agents 1 1. 2 All outhne of the historical development of antimicrobial agents 2 1. 3 Reasons for studying the biochemistry and molecular biology of antimicrobial compounds 9 1. 4 Uncovering the molecular basis of antimicrobial action iO 1. 5 Current trends in the discovery of antimicrobial drugs 14 1. 6 . Scope and layout of the book 15 2 VULNERABLE SHIELDS¿THE CELL WALLS OF BACTERIA AND FUNGI 17 2. 1 Functions of the ceU wall 17 2. 2 . Structure of the bacterial wall 17 2. 3 Structure and biosynthesis of peptidoglycan 22 2. 4 Antibiotics that inhibit peptidoglycan biosynthesis 29 2. 5 Drugs that interfere with the biosynthesis of the cell wall of mycobacteria 39 2. 6 The fungal cell wall as a target for antifungal drugs 41 3 ANTIMICROBIAL AGENTS AND CELL MEMBRANES 47 3. 1 Microbe killers: antiseptics and disinfectants 47 3. 2 Cationic peptide antibiotics 52 3. 3 lonophoric antibiotics 54 3. 4 Antifungal agents that interfere with the function and biosynthesis of membrane sterols 59 4 INHIBITORS OF NUCLEIC ACID BIOSYNTHESIS 65 4. 1 Compounds affecting the biosynthesis and utilization of nucleotide precursors 66 4. 2 Nucleoside analogues 70 4. 3 Inhibitors of the reverse transcriptase of the human immunodeficiency virus 72 4. 4 Antibacterial inhibitors of topoisomerases 75 4.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 196 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - This book presents the author's new method of two-stage maximization of likelihood function, which helps to solve a series of non-solving before the well-posed and ill-posed problems of pseudosolution computing systems of linear algebraic equations (or, in statistical terminology, parameters' estimators of functional relationships) and linear integral equations in the presence of deterministic and random errors in the initial data. This book, for the first time, presents a solution of the problem of reciprocal influence of passive errors of regressors and of active errors of predictors by computing point estimators of functional relationships.

Buch. Zustand: Neu. Neuware -This book is an advanced text on the theory of forward and futures markets which aims at providing readers with a comprehensive knowledge of how prices are established and evolve in time, what optimal strategies one can expect the participants to follow, whether they pertain to arbitrage, speculation or hedging, what characterizes such markets and what major theoretical and practical differences distinguish futures from forward contracts. It should be of interest to students (MBAs majoring in finance with quantitative skills and PhDs in finance and financial economics), academics (both theoreticians and empiricists), practitioners, and regulators. Standard textbooks dealing with forward and futures markets generally focus on the description of the contracts, institutional details, and the effective (as opposed to theoretically optimal) use of these instruments by practitioners. The theoretical analysis is often reduced to the (undoubtedly important) cash-and-carry relationship and the computation of the simple, static, minimum variance hedge ratio. This book proposes an alternative approach of these markets from the perspective of dynamic asset allocation and asset pricing theory within an inter-temporal framework that is in line with what has been done many years ago for options markets.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 286 pp. Englisch.

Buch. Zustand: Neu. Neuware -Corporate Entrepreneurship and Venturing is positioned at the crossroads of the strategy and entrepreneurship fields. The common theme is how and why corporate entrepreneurship and corporate venturing can contribute to innovation and strategic renewal in large established companies, in particular it explores ways to balance exploitation and exploration in established companies. The issue is how the locus of entrepreneurship affects the way corporate entrepreneurship addresses the exploitation/exploration challenge. In some chapters corporate entrepreneurship is dispersed across the organization and they examine the key elements of an entrepreneurial culture and the organizational conditions that are favorable to entrepreneurial initiatives. The other chapters contribute to the discussion on the potential role of corporate venturing which is separated from the main parts of the organization. They examine the advantages and disadvantages of corporate venture capital programs as particular forms of focused corporate entrepreneurship.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 172 pp. Englisch.

Buch. Zustand: Neu. Neuware -Computer Security in the 21st Century shares some of the emerging important research trends reflected in recent advances in computer security, including: security protocol design, secure peer-to-peer and ad hoc networks, multimedia security, and intrusion detection, defense and measurement.Highlights include presentations of : Fundamental new security Cryptographic protocols and design A new way of measuring network vulnerability: attack surfaces Network vulnerability and building impenetrable systems Multimedia content protection including a new standard for photographic images, JPEG2000.Researchers and computer security developers will find in this book interesting and useful insights into building computer systems that protect against computer worms, computer viruses, and other related concerns.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 284 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book illustrates the basic ideas of regularity properties of functional equations by simple examples. It then treats most of the modern results about regularity of non-composite functional equations of several variables in a unified fashion. A long introduction highlights the basic ideas for beginners and several applications are also included.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 376 pp. Englisch.

Buch. Zustand: Neu. Neuware -Software Process Modeling brings together experts to discuss relevant results in software process modeling, and expresses their personal view of this field. This book focuses on new aspects of software process modeling. Specifically, it deals with socio-technological aspects, process modeling for new development types (open source software, dependability applications, etc.) and organization change management.The computer audience is placing growing demands on the software industry today. Consumers are looking for more complex products that are, at the same time, easier to use. Software developer organizations are expected to produce higher quality products and deliver them to the public faster. In so doing, however, globally distributed development teams have to cope with understaffing and changing technologies. The challenges for the software industry are apparently mounting.Over the years, a variety of software process models have been designed to structure, describe and prescribe the software systems construction process. Most recently, software process modeling is increasingly dealing with new challenges raised by the tests that the software industry has to stand.Software Process Modeling is designed for a professional audience of researchers and practitioners in industry. The book is also suitable for graduate-level students in computer science.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 236 pp. Englisch.

Buch. Zustand: Neu. Neuware -Eleanor Conlin Casella and James Symonds th The essays in this book are adapted from papers presented at the 24 Annual Conference of the Theoretical Archaeology Group, held at the University of Manchester, in December 2002. The conference session ¿An Industrial Revolution Future Directions for Industrial Arch- ology,¿ was jointly devised by the editors, and sponsored by English Heritage, with the intention of gathering together leading industrial and historical archaeologists from around the world. Speakers were asked to consider aspects of contemporary theory and practice, as well as possible future directions for the study of industrialisation and - dustrial societies. It perhaps tting that this meeting was convened in Manchester, which has a rich industrial heritage, and has recently been proclaimed as the ¿archetype¿ city of the industrial revolution (McNeil and George, 2002). However, just as Manchester is being transformed by reg- eration, shaking off many of the negative connotations associated st with factory-based industrial production, and remaking itself as a 21 century city, then so too, is the archaeological study of industrialisation being transformed. In the most recent overview of industrial archaeology in the UK, Sir Neil Cossons cautioned that industrial archaeology risked becoming a ¿one generation subject¿, that stood on the edge of oblivion, alongside th the mid-20 century pursuit of folklife studies (Cossons 2000:13). It is to be hoped that the papers in this volume demonstrate that this will not be the case.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 336 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book is a product of the BACOMET group, a group of educators-mainly educators of prospective teachers of mathematics-who first came together in 1980 to engage in study, discussion, and mutual reflection on issues in mathematics education. BACOMET is an acronym for BAsic Components of Mathematics Education for Teachers. The group was formed after a series of meetings in 1978-1979 between Geoffrey Howson, Michael Otte, and the late Bent Christiansen. In the ensuing years, BACOMET initiated several projects that resulted in published works. The present book is the main product of the BACOMET project entitled Meaning and Communication in Mathematics Education. This theme was chosen because of the growing recognition internationally that teachers of mathematics must deal with questions of meaning, sense making, and communication if their students are to be proficient learners and users of mathematics. The participants in this project were the following: Nicolas Balacheff (Grenoble, France) Maria Bartolini Bussi (Modena, Italy) Rolf Biehler (Bielefeld, Germany) Robert Davis (New Brunswick, NJ, USA) Willibald Dorfler (Klagenfurt, Austria) Tommy Dreyfus (Holon, Israel) Joel Hillel (Montreal, Canada) Geoffrey Howson (Southampton, England) Celia Hoyles-Director (London, England) Jeremy Kilpatrick-Director (Athens, GA, USA) Christine Keitel (Berlin, Germany) Colette Laborde (Grenoble, France) Michael Otte (Bielefeld, Germany) Kenneth Ruthven (Cambridge, England) Anna Sierpinska (Montreal, Canada) Ole Skovsmose-Director (Aalborg, Denmark) Conversations about directions the project might take began in May 1993 at a NATO Advanced Research Workshop of the previous BACOMET project in VIII PREFACESpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Eleanor Conlin Casella and James Symonds th The essays in this book are adapted from papers presented at the 24 Annual Conference of the Theoretical Archaeology Group, held at the University of Manchester, in December 2002. The conference session ¿An Industrial Revolution Future Directions for Industrial Arch- ology,¿ was jointly devised by the editors, and sponsored by English Heritage, with the intention of gathering together leading industrial and historical archaeologists from around the world. Speakers were asked to consider aspects of contemporary theory and practice, as well as possible future directions for the study of industrialisation and - dustrial societies. It perhaps tting that this meeting was convened in Manchester, which has a rich industrial heritage, and has recently been proclaimed as the ¿archetype¿ city of the industrial revolution (McNeil and George, 2002). However, just as Manchester is being transformed by reg- eration, shaking off many of the negative connotations associated st with factory-based industrial production, and remaking itself as a 21 century city, then so too, is the archaeological study of industrialisation being transformed. In the most recent overview of industrial archaeology in the UK, Sir Neil Cossons cautioned that industrial archaeology risked becoming a ¿one generation subject¿, that stood on the edge of oblivion, alongside th the mid-20 century pursuit of folklife studies (Cossons 2000:13). It is to be hoped that the papers in this volume demonstrate that this will not be the case.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 336 pp. Englisch.

Buch. Zustand: Neu. Neuware -Mathematics is generally considered as the only science where knowledge is uni form, universal, and free from contradictions. ¿Mathematics is a social product - a 'net of norms', as Wittgenstein writes. In contrast to other institutions - traffic rules, legal systems or table manners -, which are often internally contradictory and are hardly ever unrestrictedly accepted, mathematics is distinguished by coherence and consensus. Although mathematics is presumably the discipline, which is the most differentiated internally, the corpus of mathematical knowledge constitutes a coher ent whole. The consistency of mathematics cannot be proved, yet, so far, no contra dictions were found that would question the uniformity of mathematics' (Heintz, 2000, p. 11). The coherence of mathematical knowledge is closely related to the kind of pro fessional communication that research mathematicians hold about mathematical knowledge. In an extensive study, Bettina Heintz (Heintz 2000) proposed that the historical development of formal mathematical proof was, in fact, a means of estab lishing a communicable ¿code of conduct' which helped mathematicians make themselves understood in relation to the truth of mathematical statements in a co ordinated and unequivocal way.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Buch. Zustand: Neu. Neuware -Non-native language teachers have often been viewed as an unavoidable fate of the profession, rather than an asset worth exploring and investigating. Now that non-natives are increasingly found teaching languages, and particularly English, both in ESL and EFL contexts, the identification of their specific contributions and their main strengths has become more relevant than ever.As a result, there has recently been a surge of interest in the role of non-native teachers but little empirical research has been published so far. This volume is particularly rich in providing different approaches to the study of non-native teachers: NNS teachers as seen by students, teachers, graduate supervisors, and by themselves. It also contributes little explored perspectives, like classroom discourse analysis, or a social-psychological framework to discuss conceptions of NNS teachers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 332 pp. Englisch.

Buch. Zustand: Neu. Neuware -As we enter into the 21'Century, the presence of technology, particularly techno-science, in everyday life is overwhelming. Institutions in the modem world are affected by this presence. Like Janus, the ancient Roman god whose double-faced head signified his knowledge of the present and the future, education has always been a two-faced enterprise. The past establishes goals and methods of Education, and the other face tries to capture the future and suggests and proposes new directions of thought and new styles of behavior for the generation which, in a few years, will take over both routines and societal innovation. History tells us that this face of Education has always been sensitive to emerging technologies. Technologies of communication and information have been particularly influential in new directions of society, in particular of education. The transition from orality to writing marked a new role for the teacher. From the sole repository of accumulated knowledge, the teacher became a guide and interpreter of registered knowledge. The emergence of hardware, in the form of documents and books, initiated a companionship between teacher and hardware. It is also remarkable how the emergence of writing strengthened individual memory, contrary to the concerns of Thamus when Theuth explained to him the discovery of writing. The conservative king was afraid that the new invention would implant forgetfulness in the souls of men.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 256 pp. Englisch.

Buch. Zustand: Neu. Neuware -Topicality of Asian economy has refused to fade for almost four decades; if anything it has been levitating. The Asian economy has changed markedly since the economic and financial crisis of 1997-1998 and is continuing to evolve. As a scholarly subject matter, Asian economy has not stopped attracting academicians, policy mandarins, decision makers in the arena of business and students of Asian economy. The Asian crisis was a cataclysmic event for the region and brought to the surface several systemic limitations, like those in the financial sector, corporate governance, regulatory oversight, legal framework, and exchange rate management. Managers of Asian economy need to get to the bottom of these acutely problematical systemic issues. Additionally, Asian economies need to change with the demands of time and devise their post crisis development strategy. Asiäs growth model, that served it so well for four decades, is overdue for renewal so that it can re-strengthen its bonds with the ever-evolving regional and global economic reality. The old growth model is likely to be less relevant and effective in the post-crisis future of the Asian economies. It is sure to run into the wall of diminishing returns.An outstanding feature of Asian Economy and Finance: A Post-Crisis Perspective is that unlike most Asia-related books, it is written in a comprehensive and authoritative manner and covers large areas of Asian macro-economy and finance. The noteworthy areas of focus include global and intra-regional trade and investment, as well as financial and monetary aspects. In-depth discussions have been provided on regional integration through expanding trade, financial flows, regional production networks, and financial and monetary co-operation. In taking a contemporary or post-crisis view of the Asian economy, this book offers the newest knowledge related to relevant themes on the Asian economies as well as the latest concepts. In a succinct manner,this book deals with the principal normative and positive strands with which one need to be properly familiar in this subject area. This tightly written volume covers a great deal of ground and imparts knowledge on the Asian economy related themes to students, researchers and policy makers alike.The book is neither overly technical nor model-oriented. It is easy to access for the target readership because of its descriptive analysis style, which stops short of mathematical formulations and econometric modeling. Many students and other readers who have good analytical minds and sound knowledge of economic principles feel lost in mathematical formulations. This writing style makes it accessible to a much larger number of readers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 336 pp. Englisch.

Buch. Zustand: Neu. Neuware -Numerous figures, illustrations, and tables; integration of new literature and concepts into field of primatology; emphasis upon both behavioral and cognitive mechanisms.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 208 pp. Englisch.

Buch. Zustand: Neu. Neuware -Exploring Probability in School provides a new perspective into research on the teaching and learning of probability. It creates this perspective by recognizing and analysing the special challenges faced by teachers and learners in contemporary classrooms where probability has recently become a mainstream part of the curriculum from early childhood through high school. The authors of the book discuss the nature of probability, look at the meaning of probabilistic literacy, and examine student access to powerful ideas in probability during the elementary, middle, and high school years. Moreover, they assemble and analyse research-based pedagogical knowledge for teachers that can enhance the learning of probability throughout these school years.With the book¿s rich application of probability research to classroom practice, it will not only be essential reading for researchers and graduate students involved in probability education; it will also capture the interest of educational policy makers, curriculum personnel, teacher educators, and teachers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 408 pp. Englisch.

Buch. Zustand: Neu. Neuware -We report a study of one aspect of the changing industrial landscape, the use of virtual team working in the supply chain. The supply chain is the group of companies that are involved in the design and manufacture and distribution of products, notably complex products such as cars. Supply chain partnerships often involve cross-company team working, and as members of such teams are rarely collocated, virtual team working supported by IT, offers considerable potential benefits. Companies hope that these technologies can be used to support distributed computer supported collaborative working for purposes such as concurrent engineering and it is this kind of virtual teaming which we decided to investigate. We believe that exploring how virtual teams communicate is an effective way of examining how well they are operating and identifying the impacts of the technologies on their interactions. In the workplace free and open communication is considered to be very important to organizations facing a rapidly changing business environment. Similarly free and equal communication among members has been reported to be important if genuine team working is to be implemented in the workplace, (Carletta et al., 1998). If organizations are to derive benefits such as innovative problem solving from virtual team working then such open communication seems desirable. Communications technologies such as videoconferencing, shared applications etc. clearly offer the possibilities of such communications among geographically distributed or virtual teams.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 352 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - Corporate Spin-Off processes are very interesting phenomena for management theory and practice. In theory, Corporate Spin-Offs are both a driver and a result of organisational change, offering the possibility to investigate an area where companies are genuinely sharing experience and best practice. In practice, Corporate Spin-Off processes are frequent and highly successful, but not as well-regarded as Merger and Acquisition strategies and less understood by the decision-makers.Success Factors of Corporate Spin-Offs was designed to meet these demands by analysing the success factors of Corporate Spin-Offs, their relative contribution to the process and the role of the different actors involved. Based on an extensive literature review and a new Spin-Off typology, a broad range of success factors and success dimensions is proposed. Using a combination of multivariate models, the responses from 211 European companies to a questionnaire are analysed and typologies derived.

Buch. Zustand: Neu. Neuware - Architecture Description Languages is an essential reference for both academic and professional researchers inthe field of system engineering and design. The papers presented in this volumewere selected from the workshop of the same name that was held as part of the World Computer Congress 2004 Conference, held in Toulouse, France in August 2004. This collection presents significant research and innovative developments and applications from both academic researchers and industry practitioners on topics ranging from Semantics to Tool and Development Environments.The aim of an ADL is to formally describesoftware and hardware architectures. Usually, an ADL describes components, their interfaces, their structures, their interactions (structure of data flow and control flow) and the mappings to hardware systems. A major goal of such description is to allow analysis with respect to several aspects like timing, safety, reliability. The papers in this state-of-the-art volume cover such topics of interest as components, connectors, composition; semantics and formalization; verification, simulation and test; tools and development environments; standardization; industrial projects.To encourage closer interaction between academic and industrial networking research communities, the workshop welcomed academic research papers as well as industrial contributions, and both are included here. Which makes this collection important not only for ADL experts and researchers, but also for all teachers and administrators interested in ADL.

Buch. Zustand: Neu. Neuware - It has been more than 80 years since Valasek first recognized the existence of a dielectric analogue to ferromagnetism, ferroelectricity, in Rochelle salt. Much as with semiconductor research, the initial studies of ferroelectric materials focused on homogeneous materials. Unlike semiconductor research, however, which rapidly expanded into n- homogeneous structures and devices, investigations of compositionally graded and layered ferroelectrics have been relatively recent endeavors. Indeed, many of the most significant results and analysis pertaining to polarization-graded ferroelectrics have only appeared in publication within the last ten years. Further extensions of these concepts to the general class of order-parameter graded ferroic materials, as depicted on the cover of this book, have (with one exception) been totally lacking. It was thus with a great deal of excitement that we assembled the manuscript for this book. The primary focus of this study is directed toward polarization-graded ferroelectrics and their active components, transpacitors; however, the findings presented here are quite general. The theory of graded 2 and 5; whereas, much of the ferroics is put on a solid foundation in chapters introductory material relies more heavily upon analogy. This was done so as to provide the reader with an intuitive approach to graded ferroics, thereby enabling them to see heterogeneous ferroics as clearly logical extensions of passive semiconductor junction devices such as p-n and n-p diodes and their active manifestations, transistors, to: transpacitors, transductors, translastics, and ultimately to the general active ferroic elements, transponents.

Buch. Zustand: Neu. Neuware.

Buch. Zustand: Neu. Neuware - This text is a light technical introduction to the three technical foundations for multimedia applications across the Internet: communications (principles, technologies and networking), compressive encoding of digital media, and Internet protocol and services. All the contributing systems elements are explained through descriptive text and numerous illustrative figures; the result is a book pitched toward non-specialists, preferably with technical background, who want descriptive tutorial introductions to the three foundation areas. The text discusses advances in digital audio/video coding, optical and wireless communications technologies, high-speed access networks, and IP-based media streaming, all crucial enablers of the multimedia Internet.

Buch. Zustand: Neu. Neuware - Covers these key topics: Shared-mesh protection for optical WDM networks.Survivable traffic grooming for hierarchical optical WDM networks.Survivable data over next-generation SONET/SDH with inverse multiplexing.

Buch. Zustand: Neu. Neuware - In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field. It became a memorable event in an illustrious series of International Symposia on Cell Volume and Signaling. This series, started by Professors Vladimir Strbák, Florian Lang and Monte Greer in Smolenice, Slovakia in 1997 and continued by Professors Rolf Kinne, Florian Lang and Frank Wehner in Berlin in 2000, is projected for 2005 in Copenhagen to be hosted by our colleague, Professor Else Hoffmann and her team. We dearly miss Monte Greer to whom this symposium was dedicated and addressed so eloquently by Vladimir Strbák in his Dedication to Monte. Monte and I became friends in Smolenice and had begun to discuss the 2003 meeting only a few days before his tragic accident in 2002. There are others who were not with us, and we missed them, too. We would not have been able to succeed in this event without the unflagging support of our higher administration at Wright State University, the NIDDKD of the National Institute of Health, and the Fuji Medical System (see Acknowledgments).

Taschenbuch. Zustand: Neu. Neuware - In human solid cancer, the lymph node (LN) status is the most important prognostic indicator for the clinical outcome of patients. Recent developments in the sentinel lymph node (SLN) concept and technology have resulted in the application of this revolutionary approach to define the first draining or SLN to which the cancer may have metastasized. The underlying thesis in solid cancer biology is that metastasis generally starts in an orderly progression, spreading through the lymphatic channels to the SLN in the nearest LN basin. Thus, the logical approach is to harvest that specific SLN for thorough analysis. Because a tumorfree SLN is usually associated with a negative residual LN basin, a negative SLN is an excellent indication that micrometastasis has not occurred in the regional LNs. When the SLN is involved, it is unknown whether or not metastasis is limited only to the SLN or if the disease has spread to the remainder of the nodal basin. For this reason, if a SLN is positive, a complete lymph node dissection is recommended. Therefore, selective sentinel lymphadenectomy (SSL) should be considered as a staging procedure so that patients with negative SLNs (about 80%) may be spared an extensive LN dissection. Malignant melanoma has been proven to be the most ideal tumor model to study the role of SLN. Subsequently, SSL has been applied to breast cancer, colon cancer and other types of solid cancer. The multidisciplinary approach encompassing the surgeon, nuclear medicine physician, and pathologist is the key to such a successful procedure. Such a team can be formed readily with appropriate training. Beyond the technical aspects of harvesting the SLN, the implication of micrometastasis remains to be defined. Because the follow-up of melanoma and breast cancer patients after SSL is crucial, ongoing clinical trials are in progress to determine the biological and clinical significance of SLNs. Although the concept of SLN is viable in other types of cancer, such as gynecological and gastrointestinal, the technical aspects of the procedure need to be perfected and verified. The most exciting possibility of SSL is that it will lead to early diagnosis of micrometastasis in regional LNs. Early diagnosis makes it useful as a clinical staging procedure, and opens up new opportunities to study micrometastasis and its evolution within the SLNs. Examining the multifaceted aspects of micrometastasis, such as differentiation of different clones with respect to the primary tumor, acquisition of adhesion molecules, and host interaction with the microscopic tumor, will shed new light on the biology of early metastasis. New molecular and genetic tools may be used to dissect the mechanisms of lymphatic and hemo togenous routes of metastasis. If such mechanisms can be understood, new therapeutic advances may be developed to prevent the process of micrometastasis. Rather than targeting larger tumor burdens such as Stage IV disease, targeted adjuvant clinical trials can be developed for high risk patients following definit ive surgical resection. SSL is a standard staging procedure for patients with melanoma and is rapidly evolving into a standard procedure for breast cancer as well.

Buch. Zustand: Neu. Neuware -What's in a name To paraphrase Shakespeare's Juliet, that which - ilie Haynsworth called the Schur complement, by any other name would be just as beautiful. Nevertheless, her 1968 naming decision in honor of Issai Schur (1875-1941) has gained lasting acceptance by the mathematical com munity. The Schur complement plays an important role in matrix analysis, statistics, numerical analysis, and many other areas of mathematics and its applications. Our goal is to expose the Schur complement as a rich and basic tool in mathematical research and applications and to discuss many significant re sults that illustrate its power and fertility. Although our book was originally conceived as a research reference, it will also be useful for graduate and up per division undergraduate courses in mathematics, applied mathematics, and statistics. The contributing authors have developed an exposition that makes the material accessible to readers with a sound foundation in linear algebra. The eight chapters of the book (Chapters 0-7) cover themes and varia tions on the Schur complement, including its historical development, basic properties, eigenvalue and singular value inequalities, matrix inequalities in both finite and infinite dimensional settings, closure properties, and appli cations in statistics, probability, and numerical analysis. The chapters need not be read in the order presented, and the reader should feel at leisure to browse freely through topics of interest.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 312 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware - Integration is an important and practical matter in today's globalized commerce. This has led companies and organizations to place increasing emphasis on creating a seamless workflow environment from one business function to another. The academic research community recognizes the importance of providing problem-solving direction to the different, and sometimes conflicting, functional perspectives of marketing, engineering, logistics, and manufacturing. The research streams that characterize these issues are in the domain of business interfaces. These include the benefits of coordination, new product development, product portfolio management, supply chain coordination, and partnerships and collaboration in the internet space.Managing Business Interfaces: Marketing, Engineering, and Manufacturing Perspectives provides state-of-the-art summary as well as new thoughts in managing business interfaces. Through eleven invited chapters, it brings together the latest developments in leading edge research related to new product development, supply chain management, e-business operations, and field studies.

Buch. Zustand: Neu. Neuware -The indications and use of shoulder arthroplasty has dramatically increased over the last decade, and this trend will continue in the future. The average age of our population is increasing, yet there is a strong desire to remain active and viable. The majority of people will not accept limitation of a joint function that compromises their life styles if a reasonable surgical solution is available. Our knowledge of disease processes has broadened and improved our understanding about how best to manage these problem¿s cli- cally. Technology and innovation have provided us with options that were not possible before. However, a successful shoulder arthroplasty depends not only on knowledge and modern technology but also on sound clinical judgment, accurate surgical technique, and appropriate postoperative rehabilitation. This book provides a comprehensive approach to dealing with the most common indications for shoulder arthroplasty. In addition, it p- vides insight into some of the more complex problems. Detailed inf- mation concerning preoperative evaluation, approaches, technology, surgical technique, and postoperative therapy will allow the surgeon to make decisions that will help his patient remain active. We thank the contributing authors for their work and commitment to this project. We appreciate the time they took from their practices and more importantly their families to complete this volume and provide an extraordinary text.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 232 pp. Englisch.

Buch. Zustand: Neu. Neuware -Glutamate receptors (GluRs) in the central nervous system have been the subject of intense investigations for several decades, providing new avenues for the understanding of excitatory neurotransmission, excitotoxicity, mechanisms of injury, and therapeutics for several acute neurological conditions, such as brain trauma, and for neurodegenerative and neuropsychiatric disorders including addictions, Alzheimer disease, etc. Evidences of GluRs beyond the central nervous system were first reported in the early 1990s. When the idea of this book was conceived, the knowledge, specificity, and functional significance of GluRs in peripheral tissues was still in its embryonic stage. From our perspective, the idea of GluRs in peripheral tissues arose from our research on seafood toxins (see Chapter 1), and has now been reinforced by the results of other scientists working in similar areas. In this book, we have invited some of the leading authorities in the field to summarize their findings and to provide a framework for further investigations. The book is divided into three sections¿ Part I is on general concepts and concentrates on the distribution and cell-specific localiza tion of glutamate receptors, their transporters, and the pharmacology in peripheral tissues and organs. Part II emphasizes the presence and implications of these receptors in specific target tissues, organs, and systems, including liver, lungs, endocrine tissues, bone, immune system, etc. Part III focuses on glutamate receptors in plants to illustrate their presence beyond the animal kingdom.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.