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Buch. Zustand: Neu. Neuware -This book gives a comprehensive treatment of the Grassmannian varieties and their Schubert subvarieties, focusing on the geometric and representation-theoretic aspects of Grassmannian varieties. Research of Grassmannian varieties is centered at the crossroads of commutative algebra, algebraic geometry, representation theory, and combinatorics. Therefore, this text uniquely presents an exciting playing field for graduate students and researchers in mathematics, physics, and computer science, to expand their knowledge in the field of algebraic geometry. The standard monomial theory (SMT) for the Grassmannian varieties and their Schubert subvarieties are introduced and the text presents some important applications of SMT including the Cohen¿Macaulay property, normality, unique factoriality, Gorenstein property, singular loci of Schubert varieties, toric degenerations of Schubert varieties, and the relationship between Schubert varieties and classical invariant theory.This text would serve well as a reference book for a graduate work on Grassmannian varieties and would be an excellent supplementary text for several courses including those in geometry of spherical varieties, Schubert varieties, advanced topics in geometric and differential topology, representation theory of compact and reductive groups, Lie theory, toric varieties, geometric representation theory, and singularity theory. The reader should have some familiarity with commutative algebra and algebraic geometry.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 184 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book is devoted to analysis and design of supply chain contracts with stochastic demand. Given the extensive utilization of contracts in supply chains, the issues concerning contract analysis and design are extremely important for supply chain management (SCM), and substantial research has been developed to address those issues over the past years. Despite the abundance of classical research, new research needs to be conducted in response to new issues emerging with the recent changing business environments, such as the fast-shortening life cycle of product and the increasing globalization of supply chains. This book addresses these issues, with the intention to present new research on how to apply contracts to improve SCM.Contract Analysis and Design for Supply Chains with Stochastic Demand contains eight chapters and each chapter is summarized as follows: Chapter 1 provides a comprehensive review of the classical development of supply chain contracts. Chapter 2 examines the effects of demand uncertainty on the applicability of buyback contracts. Chapter 3 conducts a mean-risk analysis for wholesale price contracts, taking into account contracting value risk and risk preferences. Chapter 4 studies the optimization of product service system by franchise fee contracts in the service-oriented manufacturing supply chain with demand information asymmetry. Chapter 5 develops a bidirectional option contract model and explores the optimal contracting decisions and supply chain coordination issue with the bidirectional option. Chapter 6 addresses supply chain options pricing issue and a value-based pricing scheme is developed for the supply chain options. With a cooperative game theory approach, Chapter 7 explores the issues concerning supply chain contract selection/implementation with the option contract under consideration. Chapter 8 concludes the book and suggests worthy directions for future research.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 204 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book presents applications of geometric optimal control to real life biomedical problems with an emphasis on cancer treatments. A number of mathematical models for both classical and novel cancer treatments are presented as optimal control problems with the goal of constructing optimal protocols. The power of geometric methods is illustrated with fully worked out complete global solutions to these mathematically challenging problems. Elaborate constructions of optimal controls and corresponding system responses provide great examples of applications of the tools of geometric optimal control and the outcomes aid the design of simpler, practically realizable suboptimal protocols. The book blends mathematical rigor with practically important topics in an easily readable tutorial style.Graduate students and researchers in science and engineering, particularly biomathematics and more mathematical aspects of biomedical engineering, would find this book particularly useful.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 516 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book is a unique selection of work by world-class experts exploring the latest developments in Hamiltonian partial differential equations and their applications. Topics covered within are representative of the field¿s wide scope, including KAM and normal form theories, perturbation and variational methods, integrable systems, stability of nonlinear solutions as well as applications to cosmology, fluid mechanics and water waves.The volume contains both surveys and original research papers and gives a concise overview of the above topics, with results ranging from mathematical modeling to rigorous analysis and numerical simulation. It will be of particular interest to graduate students as well as researchers in mathematics and physics, who wish to learn more about the powerful and elegant analytical techniques for Hamiltonian partial differential equations.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 464 pp. Englisch.

Buch. Zustand: Neu. Neuware -This timely text examines normative and pathological brain/behavior connections across the male lifespan, and how these findings can best inform research, intervention, and prevention. It spotlights possible etiologies for male-dominated pathology, including academic deficits and disorders relating to violence, as well as identifying men's psychological resilience and vulnerabilities throughout life. Clinical and social issues are intricately linked here, particularly in areas such as substance abuse, emotion processing, and sequelae of brain trauma. In these ways, the text moves on from the simplistic view of males as the standard in psychological studies while respecting complicated questions about biology and environment that have yet to be resolved. Since the inception of psychology, much research has focused specifically on men but few studies have offered distinctive interventions developed to help this unique male population. This volume fills the chasm left from many seminalstudies.Among the featured topics: Imaging and development: relevant findings in males. Understanding the neuropsychology of autism spectrum disorders in men. Understanding disorders of defiance, aggression, and violence in males. Serving men with traumatic brain injuries. Men at risk: special education and incarceration. The neuropsychological basis of emotion and social cognition in men.The Neuropsychology of Men offers neuropsychologists, clinical psychologists, and rehabilitation specialists an evidence-based framework for understanding male-specific cognitive and behavioral trends in the normative population, and for identifying and addressing challenges in boys and men outside the norm.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Statistics and Analysis of Scientific Data covers the foundations of probability theory and statistics, and a number of numerical and analytical methods that are essential for the present-day analyst of scientific data. Topics covered include probability theory, distribution functions of statistics, fits to two-dimensional datasheets and parameter estimation, Monte Carlo methods and Markov chains. Equal attention is paid to the theory and its practical application, and results from classic experiments in various fields are used to illustrate the importance of statistics in the analysis of scientific data.The main pedagogical method is a theory-then-application approach, where emphasis is placed first on a sound understanding of the underlying theory of a topic, which becomes the basis for an efficient and proactive use of the material for practical applications. The level is appropriate for undergraduates and beginning graduate students, and as a reference for the experienced researcher. Basic calculus is used in some of the derivations, and no previous background in probability and statistics is required.The book includes many numerical tables of data, as well as exercises and examples to aid the students' understanding of the topic.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 320 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume mirrors the holistic feature of whole genome amplification (WGA) technology by combining reviews, detailed basic methods and advanced sample workflows. The first part of the book covers an overview of the development of WGA techniques throughout recent years including general considerations on bias in WGA, possible sample pre-enrichment strategies and how to run a single-cell lab. The second part focuses on major WGA methods and protocols that allow the assessment of WGA product quality. The final chapters contain advanced protocols and address issues such as sample preparation using laser-micro dissection; WGA from partially degraded DNA (formalin-fixed paraffin embedded samples); circulating tumor cells; and ancient samples. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Authoritative and thorough, Whole Genome Amplification: Methods and Protocols will serve as a rich source of detailed information and inspiration and will help researchers, both new and experienced, yield successful results.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 296 pp. Englisch.

Buch. Zustand: Neu. Neuware -Sensorimotor integration, the dynamic process by which the sensory and motor systems communicate with each other, is crucial to humans¿ and animals¿ ability to explore and react to their environment. This book summarizes the main aspects of our current understanding of sensorimotor integration in 10 chapters written by leading scientists in this active and ever-growing field. This volume focuses on the whisker system, which is an exquisite model to experimentally approach sensorimotor integration in the mammalian brain.In this book, authors examine the whisker system on many different levels, ranging from the building blocks and neuronal circuits to sensorimotor behavior. Neuronal coding strategies, comparative analysis as well as robotics illustrate the multiple facets of this research and its broad impact on fundamental questions about the neurobiology of the mammalian brain.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 288 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book covers recent developments in the non-standard asymptotics of the mathematical narrow escape problem in stochastic theory, as well as applications of the narrow escape problem in cell biology. The first part of the book concentrates on mathematical methods, including advanced asymptotic methods in partial equations, and is aimed primarily at applied mathematicians and theoretical physicists who are interested in biological applications. The second part of the book is intended for computational biologists, theoretical chemists, biochemists, biophysicists, and physiologists. It includes a summary of output formulas from the mathematical portion of the book and concentrates on their applications in modeling specific problems in theoretical molecular and cellular biology.Critical biological processes, such as synaptic plasticity and transmission, activation of genes by transcription factors, or double-strained DNA break repair, are controlled by diffusion in structures that have both large and small spatial scales. These may be small binding sites inside or on the surface of the cell, or narrow passages between subcellular compartments. The great disparity in spatial scales is the key to controlling cell function by structure. This volume reports recent progress on resolving analytical and numerical difficulties in extracting properties from experimental data, biophysical models, and from Brownian dynamics simulations of diffusion in multi-scale structures.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 280 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume provides current up-to-date protocols for preparing the ovary for various imaging techniques, genetic protocols for generating mutant clones, mosaic analysis and assessing cell death. Chapters address methods for performing genome wide gene expression analysis and bioinformatics for studies of RNA-protein interactions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Drosophila Oogenesis: Methods and Protocols aims to ensure successful results in the further study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 260 pp. Englisch.

Buch. Zustand: Neu. Neuware -This detailed volume explores key state-of-the-art computational applications that are crucial in Systems Toxicology. The recent technological developments in experimental biology and multi-omics measurements that enable Systems Biology and Systems Toxicology can only be fully leveraged by the application of a broad range of computational approaches ranging from data management to mathematical modeling. Taking this into account, chapters in this book cover data management and processing, data analysis, biological network building and analysis, as well as the application of computational methods to toxicological assessment.Written for the Methods in Pharmacology and Toxicology series, Computational Systems Toxicology includes the kind of key practical advice that will aid readers in furthering our knowledge of toxic substances and reactions to them.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 440 pp. Englisch.

Buch. Zustand: Neu. Neuware -This fourth edition reflects the most recent technical advances in DNA-protein interaction research. With fully updated chapters that describe techniques proven by their continuous value, the volume also many new chapters have been added that mostly deal with larger-scale experiments, reflecting recent advances in 'big biology', combining to offer a very useful compendium of protocols allowing readers to delve into the intricacies of protein-DNA interaction at levels ranging from the very small (as in the case of single-molecule FRET) to the very complex (as with circular chromatin conformation capture or 4C). Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Authoritative and up-to-date, DNA-Protein Interactions: Principles and Protocols, Fourth Edition will aid researchers in continuing the incredible progress made in this vital area of study.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 360 pp. Englisch.

Buch. Zustand: Neu. Neuware -Atherosclerosis represents the leading cause of mortality and morbidity in the world. Two of the most common, severe, diseases that may occur, acute myocardial infarction and stroke, have their pathogenesis in the atherosclerosis that may affect the coronary arteries as well as the carotid/intra-cranial vessels. Therefore, in the past there was an extensive research in identifying pre-clinical atherosclerotic diseases in order to plan the correct therapeutical approach before the pathological events occur. In the last 20 years imaging techniques and in particular Computed Tomography and Magnetic Resonance had a tremendous improvement in their potential. In the field of the Computed Tomography the introduction of the multi-detector-row technology and more recently the use of dual energy and multi-spectral imaging provides an exquisite level of anatomic detail. The MR thanks to the use of strength magnetic field and extremely advanced sequences can image human vessels very quickly while offering an outstanding contrast resolution. ¿Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 248 pp. Englisch.

Buch. Zustand: Neu. Neuware -In this volume, expert researchers detail protocols for evaluating the protean effects of immunosenescence on innate and adaptive immune function, including approaches to the analysis of antigen receptor repertoire. In addition, Immunosenecence: Methods and Protocols guides readers throughcell biology and biochemical methods for analyses of telomere dysfunction, autophagy, proteinoxidation, microRNAs and DNA methylation. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical,Immunosenecence: Methods and Protocolsprovides a mixture of basic and advanced protocols that will be useful for immunologists in general and investigators in aging biology in particular.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 288 pp. Englisch.

Buch. Zustand: Neu. Neuware -This authoritative reference examines the causes of--and offers workable solutions to--the widespread problem of musculoskeletal injuries among armed forces personnel. Specific chapters on combat, non-combat, training, and fitness injuries shed necessary light on the nature and scope of the epidemic, including impact on active service members and the resulting quality of life issues in veterans. An overview of these injuries by anatomic region highlights treatment, disability, and prevention issues in military settings. The book also translates the standard public health model for preventing injuries into military context, giving professionals guidelines for developing strategies tailored to the unique strengths and risks of this population.Featured in the coverage: The burden of musculoskeletal injuries in the military. Traumatic combat injuries. Deployment and non-battle injuries. Epidemiology of musculoskeletal injuries by anatomic region. Application of the public health model for injury prevention. Barriers to injury prevention in the military.Its depth of detail makes Musculoskeletal Injuries in the Military critical reading for orthopedic surgeons, physical therapists, athletic trainers, military leaders, military and VA healthcarestaff including physicians and policymakers, public health and injury prevention professionals, occupational health and safety professionals, musculoskeletal injury and disease researchers, and veterans' health advocacy groups.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 332 pp. Englisch.

Buch. Zustand: Neu. Neuware -This text is designed to provide a comprehensive and state-of-the-art overview of the major issues specific to technological advances the field trauma, critical care and many aspects of surgical science and practice. Care of these patients and clinical conditions can be quite complex, and materials have been collected from the most current, evidence-based resources. The sections of the text have been structured to review the overall scope of issues dealing with trauma, critical care and surgery, including cardiothoracic surgery, vascular surgery, urology, gynecology and obstetrics, fetal surgery and orthopedics. This volume represents the most comprehensive textbook covering a wide range of topics and technological advances including genomics and nanotechnologies that affect patients¿ care and surgeons¿ practice daily. The multidisciplinary authorship includes experts from all aspects of trauma, surgery and critical care. The volume highlights the dramatic changes in the fieldincluding hand held devices and smart phones used in daily medical and surgical practice, complex computers in the critical care units around the world, and robotics performing complex surgical procedures and tissue engineering.Technological Advances in Surgery, Trauma and Critical Care provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in trauma, critical care, and all the specialties of surgery. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 688 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume provides a comprehensive, step by step description of the surgical techniques that the author has used in more than 13,000 vaginal reconstructive procedures. Chapters cover surgery for incontinence, prolapse, urethral diverticula, vaginal fistula, reconstruction, surgery for urethral obstruction and vaginal cysts and masses, and lastly, complications of vaginal surgery. Each surgical chapter covers a succinct summary of diagnosis, indications for surgery, and the surgical procedure itself. Sequential operative photographs, drawings, and videos guide are also included to guide the reader through the procedural steps.The Atlas of Vaginal Reconstructive Surgery will serve as a valuable resource for urologists, gynecologists and other specialists with an interest in vaginal reconstructive surgery.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 340 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume examines ways in which service delivery to individuals with autism can be improved from both ends of the basic-applied research spectrum. It introduces the concept of translational scholarship and examines real-world value in developing relevant interventions. Each area of coverage reviews current findings on autism from basic research and, then, discusses the latest applied research literature to create a roadmap for researchers, clinicians, and scientist-practitioners to develop new, effective strategies as children, adolescents, and adults with autism continue to learn and grow.Featured coverage includes:Why practice needs science and how science informs practice.The social learning disorder of stimulus salience in autism.Assessment and treatment of problem behaviors associated with transitions.Understanding persistence and improving treatment through behavioral momentum theory.The behavioral economics of reinforcer value.Increasing tolerance for delay with children and adults with autism.Autism Service Delivery is an essential resource for researchers, clinicians and scientist-practitioners, and graduate students in the fields of developmental psychology, behavioral therapy, social work, clinical child and school psychology, occupational therapy, and speech pathology.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 512 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume explores the revolutionary fMRI field from basic principles to state-of-the-art research. It covers a broad spectrum of topics, including the history of fMRI's development using endogenous MR blood contrast, neurovascular coupling, pulse sequences for fMRI, quantitative fMRI; fMRI of the visual system, auditory cortex, and sensorimotor system; genetic imaging using fMRI, multimodal neuroimaging, brain bioenergetics and function and molecular-level fMRI. Comprehensive and intuitively structured, this book engages the reader with a first-person account of the development and history of the fMRI field by the authors. The subsequent sections examine the physiological basis of fMRI, the basic principles of fMRI and its applications and the latest advances of the technology, ending with a discussion of fMRI¿s future. fMRI: From Nuclear Spins to Brain Function, co-edited by leading and renowned fMRI researchers Kamil Ugurbil, Kamil Uludag and Lawrence Berliner, is an ideal resource for clinicians and researchers in the fields of neuroscience, psychology and MRI physics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 948 pp. Englisch.

Buch. Zustand: Neu. Neuware -The Second Edition of this essential handbook provides a comprehensive, updated overview of the science that informs best practices for the implementation of response to intervention (RTI) processes within Multi-Tiered Systems of Support (MTSS) to facilitate the academic success of all students. The volume includes insights from leading scholars and scientist-practitioners to provide a highly usable guide to the essentials of RTI assessment and identification as well as research-based interventions for improving students¿ reading, writing, oral, and math skills. New and revised chapters explore crucial issues, define key concepts, identify topics warranting further study, and address real-world questions regarding implementation.Key topics include:Scientific foundations of RTIPsychometric measurement within RTIRTI and social behavior skillsThe role of consultation in RTIMonitoring response to supplemental servicesUsing technology to facilitate RTIRTI and transition planningLessons learned from RTI programs around the countryThe Second Edition of the Handbook of Response to Intervention is an essential resource for researchers, graduate students, and professionals/scientist-practitioners in child and school psychology, special and general education, social work and counseling, and educational policy and politics. 768 pp. Englisch.