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Buchbeschreibung Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The majority of the inhibition in the brain is mediated by GABA-A receptors. Extrasynaptic GABA-A receptors maintain a mild and continuous inhibition known as tonic inhibition. This study determines whether downregulation of tonic inhibition mediated by extrasynaptic GABA-A receptors is causally linked to the formation and/or maintenance of epilepsy-like activity. If true, it paves way for designing novel strategies to treat epilepsy-like brain states. A selective extrasynaptic GABA-A receptor agonist, Gaboxadol (THIP), was used to enhance tonic inhibition. Gaboxadol is a hypotic and was previously developed by Lundbeck and Merck as an experimental sleep drug. This study details the effect of low concentrations of Gaboxadol on CTZ (cyclothiazide) induced epilepsy-like activity in neuronal cultures. The data herein suggests that tonic inhibition contributes towards maintenance of cellular epilepsy and drugs that activate it could be potential therapeutic agents for pathological states like epilepsy. 72 pp. Englisch. Bestandsnummer des Verkäufers 9783639175196
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Buchbeschreibung Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The majority of the inhibition in the brain is mediated by GABA-A receptors. Extrasynaptic GABA-A receptors maintain a mild and continuous inhibition known as tonic inhibition. This study determines whether downregulation of tonic inhibition mediated by extrasynaptic GABA-A receptors is causally linked to the formation and/or maintenance of epilepsy-like activity. If true, it paves way for designing novel strategies to treat epilepsy-like brain states. A selective extrasynaptic GABA-A receptor agonist, Gaboxadol (THIP), was used to enhance tonic inhibition. Gaboxadol is a hypotic and was previously developed by Lundbeck and Merck as an experimental sleep drug. This study details the effect of low concentrations of Gaboxadol on CTZ (cyclothiazide) induced epilepsy-like activity in neuronal cultures. The data herein suggests that tonic inhibition contributes towards maintenance of cellular epilepsy and drugs that activate it could be potential therapeutic agents for pathological states like epilepsy. Bestandsnummer des Verkäufers 9783639175196
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Buchbeschreibung Kartoniert / Broschiert. Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Pitre AnarAnar Pitre is a Neuroscience doctoral candidate at Cornell University. She is currently studying the cerebellar control of eye movements and the oculomotor neural integrator. Anar enjoys communicating science and understand. Bestandsnummer des Verkäufers 4964230
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Buchbeschreibung Paperback. Zustand: Brand New. 72 pages. 8.66x5.91x0.17 inches. This item is printed on demand. Bestandsnummer des Verkäufers zk3639175190
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