Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors: International Symposium Proceedings: 3rd (Advances in Experimental Medicine and Biology) - Hardcover

Hardcover

ISBN 10: 030643928X ISBN 13: 9780306439285

Verlag: Springer, 1991

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Reseña del editor:

This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.

Reseña del editor:

The focus of these proceedings is on the interplay of genetics, hormone secretion, regulation, and molecular receptors for growth factors and insulin. Contributors deal with the structural and regulatory aspects of IGFs, insulin-like growth factor binding proteins, the importance of receptors for bi

Über diese Auflage

• Verlag: Springer
• Erscheinungsdatum: 1991
• ISBN 10: 030643928X
• ISBN 13: 9780306439285
• Einband: Tapa dura
• Anzahl der Seiten: 498
• Herausgeber: LeRoith Derek, Raizada Mohan K.