Wnt/ -Catenin Signaling in Vertebrate Posterior Neural Development (Colloquium Series on Developmental Biology) - Softcover

Elkouby, Yaniv; Frank, Dale

Softcover

ISBN 10: 1615040544 ISBN 13: 9781615040544

Verlag: Biota Publishing, 2010

Inhaltsangabe

Páginas:86Géneros:12:PS:Biology,lifesciences12:PSC:DevelopmentalbiologySinopsis:TheWnt/β-cateninsignalingpathwayisakeyregulatorofcellfatespecification,differentiation,andgrowthinmultiplesystemsthroughouttheanimalkingdom.Invertebrateposteriorneuraldevelopment,Wnt/β-cateninsignalingcontrolsthiscomplexmultistepprocess.Itinitiallyinducestheposteriorregionsofthenervoussystem,includingthemid-hindbrainborder,hindbrain,spinalcordandneuralcrest,andthensubsequentlyfine-tunesthepatternofeachregionanddeterminesthedifferentcellfateswithinthem.Inthisreview,weexplorethefunctionoftheWnt/β-cateninpathwayduringtheformationofthesespecificposteriorneuralregions.WehaveexaminedtheimportanttranscriptionaltargetsoftheWnt/β-cateninpathwayactingdownstreamtomediateitsmorphogeneticactivity.Differentregulatorynetworksareactivatedindifferentposteriorneuralregions,andthesenetworksinducespecificneuralcelltypesineachregion.EludidatinghoweachofthesenetworksspecifydifferentcellfatesiscrucialforunderstandingthebasictenetsofhowWntmorphogeneticactivityinducestheposteriornervoussystemduringtheearlieststagesofvertebratedevelopment.TableofContents

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Reseña del editor:

The Wnt/β-catenin signaling pathway is a key regulator of cell fate specification, differentiation, and growth in multiple systems throughout the animal kingdom. In vertebrate posterior neural development, Wnt/β-catenin signaling controls this complex multistep process. It initially induces the posterior regions of the nervous system, including the mid-hindbrain border, hindbrain, spinal cord and neural crest, and then subsequently fine-tunes the pattern of each region and determines the different cell fates within them. In this review, we explore the function of the Wnt/β-catenin pathway during the formation of these specific posterior neural regions. We have examined the important transcriptional targets of the Wnt/β-catenin pathway acting downstream to mediate its morphogenetic activity. Different regulatory networks are activated in different posterior neural regions, and these networks induce specific neural cell types in each region. Eludidating how each of these networks specify different cell fates is crucial for understanding the basic tenets of how Wnt morphogenetic activity induces the posterior nervous system during the earliest stages of vertebrate development. Table of Contents: Introduction / Making the Neural Rear / Wnt Morphogenetic Activity in Neural Posterior Induction / Induction of the Midbrain-Hindbrain Border / Induction of the Hindbrain / Induction of the Spinal Cord / Downstream of Wnt: Hindbrain or Spinal Cord? / Neural Crest Induction / Anti-Wnt Anterior Determinants / The Role of Mesoderm and Specific Wnt Ligands in Neural Patterning / Concluding Remarks / References

Biografía del autor:

Department of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion - Israel Institute of Technology Department of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion - Israel Institute of Technology

Über diese Auflage

• Verlag: Biota Publishing
• Erscheinungsdatum: 2010
• ISBN 10: 1615040544
• ISBN 13: 9781615040544
• Einband: Tapa blanda
• Anzahl der Seiten: 86