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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -One of the keys to success in the IC industry is getting a new product to market in a timely fashion and being able to produce that product with sufficient yield to be profitable. There are two ways to increase yield: by improving the control of the manufacturing process and by designing the process and the circuits in such a way as to minimize the effect of the inherent variations of the process on performance. The latter is typically referred to as 'design for manufacture' or 'statistical design'. As device sizes continue to shrink, the effects of the inherent fluctuations in the IC fabrication process will have an even more obvious effect on circuit performance. And design for manufacture will increase in importance. We have been working in the area of statistically based computer aided design for more than 13 years. During the last decade we have been working with each other, and individually with our students, to develop methods and CAD tools that can be used to improve yield during the design and manufacturing phases of IC realization. This effort has resulted in a large number of publications that have appeared in a variety of journals and conference proceedings. Thus our motivation in writing this book is to put, in one place, a description of our approach to IC yield enhancement. While the work that is contained in this book has appeared in the open literature, we have attempted to use a consistent notation throughout this book. 308 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During the past two decades, virus taxonomy has advanced to the point where most viruses can be classified as belonging to families, genera, or groups of related viruses. Virus classification is primarily based on chem ical and physical similarities, such as the size and shape of the virion, the nature of the genomic nucleic acid, the number and function of com ponent proteins, the presence of lipids and of additional structural fea tures, such as envelopes, and serological interrelationships. The families, genera, or groups of viruses that have been defined on the basis of such criteria by the International Committee on Taxonomy of Viruses (ICTV) will be described in some detail in this catalogue and illustrated by elec tron micrographs. In my present attempt to list most if not all well es tablished and studied viruses in alphabetical order, I have largely confined myself to identifying them only in such taxonomic terms, generally without quoting specific data reported for individual viruses. If the latter data do not at times agree closely with those given for the taxon or group, it is difficult to decide to what extent this is attributable to misclassi fication due to insufficient data and errors in the analytical procedures and descriptions, or to what extent this is an expression of Nature's free dom of choice and abhorrence of restrictive classifications. 280 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar macological treatment is currently available. Considering the enormity of the problem in terms of human tragedy as well as the economic burden to families and societies alike, it is surprising that so little effort is being made to develop treatments for these disorders. Although no one can become inured to the victims of brain or spinal cord injuries, one reason that insufficient time and effort have been devoted to research on recovery is that it is a generally held medical belief that nervous system injuries are simply not amenable to treatment. At best, current therapies are aimed at providing symptomatic relief or focus on re habilitative measures and the teaching of alternative behavioral strategies to help patients cope with their impairments, with only marginal results in many cases. Only within the last decade have neuroscientists begun to make serious inroads into understanding and examining the inherent 'plasticity' found in the adult CNS. Ten years or so ago, very few researchers or clinicians would have thought that damaged central neurons could sprout new terminals or that intact nerve fibers in a damaged pathway could proliferate to replace inputs from neurons that died as a result of injury. 412 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cellular neurobiology has been transformed in the past decade by new technologies and fundamental discoveries. One result is an enormous increase in our understanding of how ion channels function in nerve and muscle cells and a widening perspective on the role of ion channels in non-neuronal cell physiology and development. Patch clamp techniques now permit direct observation of the transitions between functional confor mations of individual ion channels in their native membrane. Recombinant DNA techniques are being used to determine the primary structure of ion channel proteins and to test hypotheses about channel conformations, sites of grating and modulation, and the basis of ion selectivity. At the same time, biochemical techniques have revealed intricate signalling systems in side cells, involving second messengers such as calcium, phospholipids and cyclic nucleotides, which interface with the external milieu through GTP binding proteins and regulate cell metabolism by altering protein phos phorylation. This panorama of second messenger systems has greatly increas ed our application for their potential role in regulating ion channel function. We now recognize that ion channels are much more complicated than we once thought, and more interesting. They are not simply isolated macro molecules in the membrane, gated directly by depolarization or trans mitter binding to open briefly at a fixed conductance and then close or inactivate. Instead, individual channels now appear to have many open and closed states that are regulated independently by voltage and transmitters. 464 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book documents the proceedings of the Symposium on Particles in Fluids: Detection, Characterization and Control held as a part of the 18th Fine Particle Society meeting in Boston, August 3-7, 1987. This was the Premier symposium on this topic and the response was so good that we have decided to organize it on a biennial basis and the second symposium will be held under the rubric Particles in Gases and Liquids: Detection, Characterization and Control at the 20th Fine Particle Society meeting in Boston, August 22-26, 1989. In the modern manufacture of sophisticated and sensitive microelectronic components and other precision parts, there has been a great deal of concern about yield losses due to micrometer- and submicrometer-sized particles. These particles can originate from a number of sources including fluids, i. e. , gases and liquids used in the manufacturing process. So the detection, characterization and control or removal of these undesirable particles is of cardinal importance and this symposium was conceived and o~ganized with this in mind. The purposes of this symposium were to bring together those actively involved in all aspects of particles in fluids, to provide a forum for discussion of the latest techniques for the detection, characterization and control of particles, and to highlight areas which needed intensified R&D efforts. The printed program contained a total of 46 papers and a variety of topics dealing with various ramifications of particles in fluids were presented. 316 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Symposium 'Symmetries in Science III' was held at Schloss Hofen, Vorarl berg, Austria, during the period July 25-28, 1988. Some 70 invited scientists from 24 countries attended the Symposium and presented reviews, research papers and re ports, as well as participated in workshops. The format of the Symposium was delib erately kept international and interdisciplinary, and also provided an opportunity for presentations of symmetry applications in fields other than in the conventional disci plines. The Symposium was co-sponsored by Southern Illinois University at Carbondale Land Vorarlberg, U.S. Office of Naval Research (Special Session), and IBM Austria. Support by these institutions is gratefully acknowledged. Several individuals have contributed significantly to the success of Sym- sium III. They are Dr. John C. Guyon, President, Southern Illinois University, at Carbondale, Dr. Martin Purtscher, Landeshauptman des Landes Vorarlberg, Dr. Guntram Lins, Landesrat des Landes Vorarlberg, and Dr. Hubert Regner, Direktor, Landesbildungszentrum Schloss Hofen. I wish to thank these individuals for their support of Symposium III, also in the name of the participating scientists. The Symposium provided these scientists with an opportunity to get together and exchange scientific information in an efficient manner, and in a very pleasant environment. 628 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Three years ago when Professor Garry Cole visited our Mycology unit at the Pasteur Institute we discussed the possibility of organizing a small International Symposium on 'Isolation, Purification and Detection of Fungal Antigens' limited to 8 American/Canadian scientists and to 8 French participants. The location chosen was the Pasteur Institute because of the historical and current importance of the Institute as a Center for Research in Immunology and Medical Mycology. The interest demonstrated by all medical mycolo gists we contacted led us to expand the small original meeting to an international symposium in which all aspects of antigens of pathogenic and allergenic fungi and actinomycetes related to man, animals, and even plants would be discussed. Our wish was also to hold this Symposium in the same week as the Anniversary meeting of the French Society of Medical Mycology which was founded at the Pasteur Institute 30 years ago with my colleagues Gabriel Segretain and Francois Mariat. 488 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The National Center for Intermedia Transport Research (NCITR) was established at UCLA in 1982 by EPA as one of six Centers of Excellence for the study of environmental pollution problems. One of the functions undertaken by the NCITR has been to hold periodic workshops and to provide a forum for the discussion of current topiCS in the environmental pollution arena. To this end, two other workshops have previously been held. The first, held in November 1982, was chaired by H. R. Pruppacher, R. G. Semonin and W. G. N. Slinn on Precipitation Scavenging, Dry DepOSition and Resuspension. The second, held in January 1986, was chaired by Y. Cohen on Pollution Transport and Accumulation in a Multimedia Environment. The present workshop, chaired by D. T. Allen, Y. Cohen and I. R. Kaplan, was held on August 24-26, 1988 in Santa Monica, California. The title of the workshop was Intermedia Pollutant Transport: Modeling and Field Measurements. Approximately one hundred individuals participated and twenty five papers were given, mostly by invitation. The workshop was divided into the following four broad topiCS: 1) Transport of Pollutants from the Atmosphere, 2) Transport of Pollutants from Soils and Groundwaters, 3) Transport of Pollutants from Lakes and Oceans, and 4) Multimedia Transport of Pollutants. The last afternoon was reserved for a Panel Discussion. 312 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the late 1960s, the behavioral treatment of mentally retarded, au tistic, and other developmentally disabled persons has grown progres sively more sophisticated. The literature on behavioral treatment has produced effective and clinically significant programs for the reduction of maladaptive behaviors such as tantrums, aggression, and self-injury; skills deficits have been remediated through improved programs for language and life skills acquisition; and new environments have been opened in the creation of mainstream educational opportunities. In spite of these advances, it strikes us that this almost exclusive focus on behavior problems and skills remediation has been somewhat myopic and that much of the potential for application of behavioral science to solving problems of the developmentally disabled is as yet untapped. In the 1980s, an important revolution has taken place: the devel opment of the field of behavioral medicine. This field, in merging disease treatment and management with learning and behavior, has already made impressive progress toward a reconceptualization of health care that acknowledges the centrality of behavior in disease expression. Al though there has, as yet, been only a preliminary application of this reconceptualization to the field of developmental disabilities, we are convinced that further extension has great potential. 312 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -What do we know about behavioral analysis and intervention in educational settings Given that educational institutions were among the first to embrace the new technology of behavior change in the late 1950s and early 1960s, it is apparent that we have had the opportunity to learn a great deal. The evolution of the field of behavior therapy has witnessed a change in the behavior therapist from an adolescent fascination with repeatedly demonstrating the effectiveness of the new technology to a mature recognition of the complex implications of the behav ioral paradigm for individuals, systems, and society. Many 'facts' now taken for granted were considered impossibilities a mere two decades ago. In her 1986 presidential address to Division 25 of the American Psychological Association, Beth Sulzer-Azaroff reviewed a number of changes in attitude in education that were strongly influenced by behavior therapy. Most educators now agree that (a) everyone can learn, (b) complex skills can be taught, (c) precise, general, and durable performance can be taught, and (d) barriers to learning can be overcome. In addition, we would add that behavior therapy is being applied to increasingly more complex human problems, such as social skill deficits, internalizing disorders, and dysfunctional systems and organizations. 860 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In recent years, the ATP synthase (H+ ATPase, FoFrATPase) has been the subject of intensive IDvestigations in many laboratories. The major reason for this lies in the fact that this enzyme complex catalyses one of the most important reactions in living cells, namely the synthesis of ATP utilizing the energy from an electrochemical transmembrane H+ gradient, generated by the cellular respiratory chain or by the light reactions of photosynthetic organisms. The mechanism by which the H+ motive force is utilized to drive the synthesis of ATP is one of the major unsolved problems in biochemistry. Thus, the fundamental information concerning the-molecular structure and the mechanism of assembly of the ATP synthase is of major significance in cell biology. A seminar/workshop on the Molecular Structure, Function and Assembly of the ATP synthases was held in April, 1987 at the East West Center, University of Hawaii, Honolulu, Hawaii, to promote exchange of information between laboratories actively engaged in the study of the A TP synthases, and to provide a forum for discussion and coordination of data derived from molecular, genetic and biochemical approaches used in different laboratories. This volume summarizes the result of the seminar/workshop, in the form of a collection of papers presented at the meeting, and provides an overvIew of current work in this rapidly progressing area of research. 300 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -I organized this book because there is a need to put together in book form recent advances in our knowledge of how airway smooth muscle:works in health and in disease. After a period when it seemed that progress was very slow, there has been in the past few years an incredibly rapid gathering of knowledge in this area. In particular, our understanding has improved regarding the cascades of events that follow the initial binding of agonist to plasma membrane receptors and that lead to the cross-bridge movements that determine contraction. This advance in our knowledge was stimulated by use of single-and whole-cell channel recordings of plasma membrane currents and by description of the l3-receptor-GTP-binding protein-adenylate cyclase-cAMP coupling system, which serves as a model for other coupling mechanisms. The discovery of the receptor-activated inositol phospholipid transduction system has greatly stimulated research and led to advances in our understanding of mechanisms involved in smooth muscle con traction. Major advances were also triggered by the development of indicators for measuring free cytosolic calcium concentration and starting the unraveling of 2 the events involved in Ca + -dependent activation of contractile proteins. Al though most of the studies that led to our current understanding of these areas were performed on nonairway smooth muscle, these studies usually add to our understanding of airway smooth muscle, and there is an enlarging body of data that have been obtained on airway smooth muscle. 340 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -fhere is a growing perception that the succesful design and ~xploitation of complex information systems is critically dependant on :he level of methods and support for performance modelling. Fast :echnological evolution creates a strong demand for analysis :echniques which can handle new hardware and software )rganisations. Performance modelling users are expecting improved :ools in terms of their user friendliness and their integration in the ;ystem design and operation process. Providing an image as clear as possible of the recent advances in :hese areas is the objective of the serie of In t ern a t ion a 1 Conference on Modelling Techniques and Tools for Computer Performance Evaluation. We believe thst the 4th edition does respond to the objective. It illustrates the most recent trends in our jomain and gives insight into what we may expect in terms of new modelling techniques; tools and practices in the future years. The proceedings include the twenty seven papers accepted by the Program Committee (but of sixty six submitted) and three invited papers presented at the Conference. They cover the following topics: Modelling Tools Networking Architecture and Workload Protocols Architecture Configuration Parallelism ix Performability Algorithms We would like to express our sincere apprecIatIOn and gratitude to the members of the Program Committee and to the reviewers for their time and effort. Without their kind cooperation, the Conference would not have been possible. 472 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Numerous textbooks treat various aspects of food chemistry and engineering, yet little information is available on the process of industrial food research and development. Currently, no textbooks of academic courses cover the broad area of product development. This void keeps even the most qualified person from reaching an informed decision about a career in this field. This book is intended to introduce the food industry novice to the diverse facets of the profession and to serve as a useful monograph for the expert by portraying the wide scope of R&D in an industry that is market-driven and highly vulnerable to demographic fluctuations. Food industry experts from diverse disciplines provide a broad overview of the numerous aspects of suc cessful food research and development, from consumer trend analysis to com mercialization. The book also highlights some of the activities and skill requirements that are unique to an industrial food research career. We wish to express our sincere gratitude to all of the book's contributors, who have made its publication possible. 460 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Between June 6-10, 1988, the Third Chemical Congress of North America was held at the Toronto Convention Center. At this rare gathering, fifteen thousand scientists attended various symposia. In one of the symposia, Professor Pierre-Gilles de Gennes of College de France was honored as the 1988 recipient of the Amer ican Chemical Society Polymer Chemistry Award, sponsored by Mobil Chemical Corporation. For Professor de Gennes, this international setting could not be more fitting. For years, he has been a friend and a lecturer to the world scientific community. Thus, for this special occasion, his friends came to recount many of his achievements or report new research findings mostly derived from his theories or stimulated by his thoughts. In this volume of Proceedings, titled New Trends in Physics and Physical Chemistry of Polymers, we are glad to present the revised papers for the Symposium and some contributed after the Symposium. In addition, we intend to include most of the lively discussions that took plaGe during the conference. This volume contains a total of thirty-six papers divided into six parts, primarily according to the nature of the subject matter: - Adsorption of Colloids and Polymers. - Adhesion, Fractal and Wetting of Polymers. - Dynamics and Characterization of Polymer Solutions. - Diffusion and Interdiffusion of Polymers. - Entanglement and Reptation of Polymer Melts and Networks. - Phase Transitions and Gel Electrophoresis. 676 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In June 1987, neurobiologists, immunologists, molecular biologists, virologists and neurologists from several countries met in Vancouver to discuss recent advances of relevance to multiple sclerosis. The symposium was a part of the 22nd Canadian Congress of Neurological Sciences meeting and was sponsored by funds from the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada. The presentations covered five major topics: basic neurobiology, molecular biology, the role of viruses in demyelination, immune function and dysfunction in multiple sclerosis, and clinical magnetic resonance imaging studies. It was heartening to note that scientists from several different disciplines were working towards a common end-point: the understanding and treatment of multiple sclerosis. In this book, speakers at the symposium have each presented a chapter of their findings and discussions. In addition, some non-participants at the symposium have been invited to submit chapters in order to give this volume a more complete scope. It is hoped that the reader will find this book a useful reference for several subjects of interest to multiple sclerosis. In closing, I would like to thank the following for their help and support: the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada for their financial support; the contributors of this book for their manuscripts; Dr. A. Eisen, Mrs. K. Eisen, Mrs. P. Bodnarchuk and Mrs. M. Kim for their efforts in planning and organizing the symposium; and Ms. Catherine Schikowski for her secretarial assistance. Seung U. Kim, M.D. Ph.D. 288 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Guanidine is named for its similarity to the purine guanine which, in turn, is named for its principal source guano, which comes from the Inca word, huano, for dung. Guanidine, therefore, translates into dung-like, which is hardly a genteel way to introduce a subject. On the other hand, texts are seldom inspirational, 'frequently crude and rarely literary and should be judged on how successfully they assemble, organize and present current data. I am impressed that the material which fol]ows goes a long way toward successfully achieving those goals. Tue International Guanidine Society is a synthesis of three groups of investigators: biologists studying guanidines as phosphagens, neurologists interested in guanidines as convulsants and nephrologists involved with guanidines as toxins. As a member of the latter group. I am gratified by the considerable progress this book represents. To begin with. there now appears to be a common theme which unifies current speculation concerning the metabolic origin of the guanidines in uremia. At the First International Congress in 1983, evidence was presented which supported the theory that certain guanidines were products of the mixed function oxidation of urea. This year's meeting brings together overwhelming data showing that methyl guanidine is an effect of active oxygen reacting with creatinine. An idolatry, worshipped throughout biochemistry, that urea and creatinine are inert byproducts of protein metabolism, is shown to have feet of clay. 384 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Why Efforts to Expand the Meaning of 'Teratogen' Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline. 344 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The International Workshops on 'The Use of Supercomputers in Theoretical Science' have become a tradition at the Univer sity of Antwerp, Belgium. The first one took place in 1984. This volume combines the proceedings of the second work shop (December 12, 1985), of the third (June 16, 1987) and of the fourth (June 9, 1988). The principal aim of the International Workshops is to present the state-of-the-art in scientific high speed computa tion. Indeed, during the past ten years computational science has become a third methodology with merits equal to the theo retical and experimental sciences. Regretfully, access to supercomputers remains limited for academic researchers. None theless, supercomputers have become a major tool for scientists in a wide variety of scientific fields, and they lead to a realistic solution of problems that could not be solved a decade ago. It is a pleasure to thank the Belgian National Science Foundation (NFWO-FNRS) for the sponsoring of all the workshops. These workshops are organized in the framework of the Third Cy cle 'Vectorization, Parallel Processing and Supercomputers', which is also funded by the NFWO-FNRS. The other sponsor I want to thank is the University of Antwerp, where the workshops took place. The University of Antwerp (UIA), together with the NFWO-FNRS, are also the main sponsors of the ALPHA-project, which gives the scientists of Belgium the opportunity to obtain an easy supercomputer connection. 296 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Fifth International Symposium on Inclusion Phenomena and Molecular Recognition was held September 18-23, 1988 at Orange Beach, Alabama. This followed previous very successful symposia in Warsaw (1980), Parma (1982), Tokyo (1984), and Lancaster (1986). The overall tone of the event at Orange Beach was expressed elegantly by Fraser Stoddart at the close of his lecture: 'At a meeting like this, I think we should be asking ourselves more openly where we have come from and where we are going to. I am certainly willing to put my head on the block. Chemistry, as I see it, is entering a golden age of opportunity and those of us here who respond to the multidisciplinary challenge of the subject will perhaps start the movement to reunite the chemical sciences for the fIrst time in more than a century. Given the recognition granted through Charles Pedersen, Donald Cram, and Jean-Marie Lehn to our field from Stockholm last year, there are many here who are surely poised - if they have not already done so - to capture the academic high ground and intellectual leadership of our subject. And what is more - it will be on the back of our fundamental science that many of the exciting technological advances of the twenty-first century will be forged. ' In order to capture the flavor and excitement of the symposium, herein we present reviews by thirty-eight of the invited lecturers. The program was shaped by the Program Committee: Jerry L. Atwood, Richard A. 424 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The new experimental tools and approaches of modern biology have allowed us to better understand many fundamental properties of the eukaryotic cells. These significant discoveries have drastically changed the diagnostic and therapeutic approaches of modern clinical practice. On April 18-22, 1988, an International Symposium on Cell Function and Disease was held in Monterrey, Nuevo Leon, Mexico, aimed at reviewing some of the most recent advances made in the following five areas: Genes and Human Diseases; Cellular and Molecular Pathology; Infectious Diseases; Brain Transplants and the New Approaches and Techniques with Potential Application to Cell Function and Disease. This book is based on the contributed papers of the symposium. To underline the importance of the clinical approach to the study of cell function and disease a section on this subject was added at the end of the book. The chapters in this volume include contributions by some of the leading scientists of the international scientific community and Mexico. During the course of this international conference, numerous discussions were held by the local and international representatives of the scientific community concerning the creation of an International Center of Molecular Medicine aimed at stimulating further interaction between molecular biologists, biochemists, biophyscists and clinicians. Such ideas received the endorsement and support of the Director General of the united Nations Educational and Scientific Organization (UNESCO), Federico Mayor, the Governor of the State of Nuevo Leon, Jorge Trevino, and the Secretary of Health of Mexico, Guillermo Soberon. 540 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -I Polymers.- 1. Electrically Conductive Polymers.- 2. Lonically Conductive Polymers.- II Plastics.- 3. Metallic Plating and Coating on Plastics.- 4. Conductive Plastics. 192 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The proceedings of the 'International Conference on Spin Observables of Nuclear Probes' are presented in this volume. This conference was held in Telluride, Colorado, March 14-17, 1988, and was the fourth in the Telluride series of nuclear physics conferences. A continuing theme in the Telluride conference series has been the complementarity of various intermediate-energy projectiles for elucidating the nucleon-nucleon interaction and nuclear structure. Earlier conferences have contributed significantly to an understanding of spin currents in nuclei, in particular the distribution of Gamow-Teller strength using charge-exchange reactions. The previous conference on 'Antinucleon and Nucleon Nucleus Interactions' compared nuclear information from tra tional probes to recent results from antinucleon reactions. The 1988 conference on Spin Observables of Nuclear Probes, put special emphasis on spin observables and brought together experts using spin information to probe nuclear structure. Spin observables have provided very detailed information about nuclear structure and reactions. Since the 1985 Telluride conference we have seen data from new focal plane polarimeters at LAMPF, TRIUMF, IUCF and elsewhere. In addition, spin observables provide an important common ground between electron and hadron scattering physics. In the future we look forward to new facilities such as NTOF for polarized neutron measurements at Los Alamos and a vigorous spin program at CEBAF. 476 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The frontispiece, Leonardo da Vinci's drawing of the embryo in the womb, was chosen as a starting point for this book. It was Leonardo who in his not Elektronisches Buch and drawings combined artistic composition and accurate recording of the anatomy of the human body. Leonardo studied human anatomy in order to execute artistic drawings. His aim was to clarify form and function of human organs including reproductive organs. He followed up his extensive research with graphic representa tion and thereby initiated record keeping as a basis of scientific investigation. His records, accurate three-dimensional drawings, allowed others to reproduce his find ings and to test for correctness. Results could be updated and refined. Only after these steps can abnormalities be ascertained and defined as pathology. Though Leonardo was both artist and scientist, it is assumed that his anatomic drawings were used to improve his art, and thus scientific endeavor was at the service of his art. Anatomy, the offspring of science and art, is an integration of the two and became an accepted branch of the natural sciences. Although art and science continued to interact throughout the Renaissance, art was often placed in the service of science. In the course of history that followed, art and science in creasingly followed separate ways. 632 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'Psychopharmacology of the Aging Nervous System' was selected as the topic for Volume 20 of the Handbook of PsychopharmacoloffY. Senile dementia is now widely recognized as a medical and social problem likely to reach epidemic proportions by the turn of the century. By that time it is esti mated that almost 20% of the population in most developed countries will be over the age of 65 and at a conservative estimate 1 in 10 of them will suffer from a dementing illness. Many symposia have appeared over the last few years describing the neuropathological and neurochemical deficiencies in Alzheimer's and other forms of dementia, the neuropsychological features of the disease, and attempts to treat it. In this volume, we have selected topics and authors who are beginning to question some of the earlier assumptions and to ask different questions about dementia. In the first four chapters the neuropathology and neu rochemistry of dementia are reevaluated. It is important to understand the relationship between the formation of amyloid plaques and neurofibrillary tangles, the progressive degeneration in cortex, and the neurochemical deafferentation of cortex. In particular, the possibility is considered that the most severe pathology is seen in a well-defined limbo/cortical circuitry known to be involved in mnemonic processing. The growing interest in the genetic determinants of familial Alz heimer's is reviewed. It is also recognized that detailed comparisons of the neural and psychological characteristics of the various degenerative dis eases that impair cognitive processing may be valuable. 504 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This collection of 101 short communications, submitted by some of the participants at the 11th Nuclear Workshop held in Suzdal, USSR, 18-23 September, 1989, provides a representative survey of the material presented at the Workshop. Articles have been submitted by both those who delivered lectures and those who had poster presentations. The order of presentation at the Nuclear Workshop is roughly maintained within this proceedings book, but the session titles within the scientific program have not been utilized as discrete subdivisions within the book, because of the considerable overlap of subject matter. The overall sequence is as follows: Genome structure, Gene Structure and Expression, Nucleolar Genes, Structure and Proteins, Chromatin and Nuclear Granules, Nuclear Matrix and Nuclear Proteins, Replication and Transcription and finally Nuclear Envelope and Nuclear Cytoplasmic Transport. Several articles on Nuclear Lipids are also included, stemming from an evening round-table discussion on lipids. The third Wilhelm Bernhard Lecture was delivered in Suzdal by Professor Harris Busch, who can be seen in the photograph above (on the left) in the presence of Professor Ilya B. Zbarsky, President of the organizing committee for the 11th Nuclear Workshop. (Previous Wilhelm Bernhard lecturers have been Ronald H. Reeder, in Krakow, Poland, 1985 and Oscar L. Miller, Jr. , in Stevensbeek, The Netherlands, in 1987). 524 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents the contributions of the participants in the Sixth International Swarm Seminar, held August 2-5, 1989, at the Webb Institute in Glen Cove, New York. The Swarm Seminars are traditionally held as relatively small satellite conferences of the International Conference on the Physics of Electronic and Atomic Collisions (ICPEAC) which occurs every two years. The 1989 ICPEAC took place in New York City prior to the Swarm Seminar. The focus of the Swarm Seminars has been on basic research relevant to understanding the transport of charged particles, mainly electrons and ions, in weakly ionized gases. This is a field that tends to bridge the gap between studies of fundamental binary atomic and molecular collision processes and studies of electrical breakdown or discharge phenomena in gases. Topics included in the 1989 seminar ranged the gamut from direct determinations of charged-particle collision cross sections to use of cross sections and swarm parameters to model the behavior of electrical gas discharges. Although the range of subjects covered was in many respects similar to that of previous seminars, there was an emphasis on certain selected themes that tended to give this seminar a distinctly different flavor. There was, for example, considerable discussion on the meaning of 'equilibrium' and the conditions under which nonequilibrium effects become important in the transport of electrons through a gas. 480 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The idea for this book arose during the 1985 Gordon Conference on 'Mammary Gland Biology'. New developments in the methodology of cell biology and the explosive growth of molecular biology had begun to impact upon our understanding of mammary gland growth and function. It seemed a propitious time for summarizing the current status of knowledge of the cell and molecular biology of mammary cancer and for attempting to outline future areas of concern and interest. The reviews presented here were completed by the Fall of 1986. Although new insights will surely continue to emerge, it is hoped that the material in this volume will form not only a current update but a basic core of information for future experiments. We have not attempted to cover all areas of mammary gland transformation. Those areas where recent detailed reviews are already available have been omitted. Also, the areas of normal gland development, cell ultrastructure, hormone responsiveness, chemotherapy and clinical aspects of mammary cancer have not been included. Instead, we have selected those areas where the development of new methodology, reagents and results have led to new ideas about mammary gland function and development as they are related to neoplasia. 536 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -There is a need to solve problems in solid and fluid mechanics that currently exceed the resources of current and foreseeable supercomputers. The issue revolves around the number of degrees of freedom of simultaneous equations that one needs to accurately describe the problem, and the computer storage and speed limitations which prohibit such solutions. The goals of tHis symposium were to explore some of the latest work being done in both industry and academia to solve such extremely large problems, and to provide a forum for the discussion and prognostication of necessary future direc tions of both man and machine. As evidenced in this proceedings we believe these goals were met. Contained in this volume are discussions of: iterative solvers, and their application to a variety of problems, e.g. structures, fluid dynamics, and structural acoustics; iterative dynamic substructuring and its use in structural acoustics; the use of the boundary element method both alone and in conjunction with the finite element method; the application of finite difference methods to problems of incompressible, turbulent flow; and algorithms amenable to concurrent computations and their applications. Furthermore, discussions of existing computational shortcomings from the big picture point of view are presented that include recommendations for future work. 316 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Shaul G. Massry Division of Nephrology, The University of Southern California, School of Medicine Los Angeles, California In the last two decades evidence has accumulated indicating that parathyroid hormone may exert a multitude of effects on many cells and a variety of organs beyond its classical targets: the kidney and the bone. These efforts have been spearheaded by nephrologists. The interest of this group of clinicians-scientists stems from the fact that patients with renal failure have secondary hyperparathyroidism and markedly elevated blood levels of PTH (1,2). If this hormone does act on various organs, it becomes plausible that excess blood levels of PTH may be harmful in these patients. Indeed, in an Editorial published in 1977, Massry suggested that the elevated blood levels of PTH in patients with renal failure may exert deleterious effects on many systems and as such may participate in the genesis of many of the manifestations of the uremic syndrome (3). Thus, the essence of the Massry hypothesis is the notion that PTH may act as a major uremic toxin. The search for uremic toxins did not yield successful results. In the last three decades many compounds have been implicated as uremic toxins. However, a cause and effect relationship between these compounds and the manifestations of the uremic syndrome has not been established in most cases. 496 pp. Englisch.