Antiviral Agents: Advances and Problems (Progress in Drug Research): 002 - Softcover

Softcover

ISBN 10: 3764365471 ISBN 13: 9783764365479

Verlag: Birkhäuser Basel, 2002

Inhaltsangabe

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Über diesen Titel

Reseña del editor:

This first Special Volume of the monograph series "Progress in Drug Research" is a compilation of most topical and concise reviews on virus research and drug development. Latest "Progress in Drug Research" articles dealing with new chemotherapeutics for the treatment of the most threatening viral diseases have been compiled and supplemented with upgraded contributions from earlier PDR publications. Altogether, a concise account of latest findings and advances in HIV and hepatitis virus as well as herpes- and influenzavirus research is given. Other worldwide diseases, like polio, hepatitis A and the common cold, are dealt with in context with the broad family of picornaviruses. The unfortunate appearance of AIDS, the manyfold problems with herpesviruses and other viruses attacking humans have led to an enormous dynamism of worldwide research and to an immense increase in the corresponding literature. With this first Special-Topic volume, composed of updated contributions from the monograph series "Progress in Drug Research" the Editor and the Publisher undertake an effort to supply concise reviews on virus research, especially on the development of new and future antiviral agents in some important and widespread viral diseases. Latest "Progress in Drug Research" articles dealing with new chemotherapeutics for the treatment of the most threatening viral diseases are presented. These very well received articles were upgraded and supplemented with new chapters to form this actual overview of the achievements in the respective fields of virus research. This special volume contains six review articles covering the latest studies on the HIV and hepatitis C and B virus as well as herpes- and influenzaviruses. Other worldwide diseases, like polio, hepatitis A and the common cold, are dealt with in context with the broad family of picornaviruses.

Reseña del editor:

In the treatment of infections caused by rapidly mutating viruses like human immunodeficiency virus (HIV), combination therapy with multiple drugs act­ ing by different mechanisms offers several advantages over monotherapy. It may provide: synergistic effect, possible reduction of dosages and side-effects, and reduction of the chance of drug resistance. In the past few years, hun­ dreds of HIV protease inhibitors have been synthesized and tested in order to overcome the limitations of reverse transcriptase inhibitors like zidovudine and others. In this review, emphasis is placed on the development of HIV pro­ tease inhibitors as antiviral agents against HIY, and structure-activity rela­ tionship analysis of saquinavir and related compounds. Limitations of some protease inhibitors and ways to overcome the shortcomings are presented. Among these many protease inhibitors five have been marketed during 1995-1999. They are saquinavir, ritonavir, indinavir, nelfinavir and ampre­ navir. Their different structural features, important physicochemical, phar­ macokinetic and clinical profiles are presented in a table form for easy com­ parison. It is hoped that in the future new drugs based on additional mech­ anisms can be developed for the treatment of AIDS. Contents 4 1 Introduction .................................................................... . HIV protease as a target for chemotherapy ................................... . 2 5 Design of protease inhibitors .................................................. . 3 5 Basis of rational design of HIV protease inhibitors ........................... . 3.1 5 New development of HIV protease inhibitors ................................ . 6 3.2 HIV protease inhibitors on the market ........................................ . 20 4 20 4.1 SAR of saquinavir and related compounds .................................... .

Über diese Auflage

• Verlag: Birkhäuser Basel
• Erscheinungsdatum: 2002
• ISBN 10: 3764365471
• ISBN 13: 9783764365479
• Einband: Tapa blanda
• Anzahl der Seiten: 268
• Herausgeber: Jucker Ernst