Catalytic Oxidation Reagents: 05 (Handbook of Reagents for Organic Synthesis) - Hardcover

Hardcover

ISBN 10: 1119953278 ISBN 13: 9781119953272

Verlag: John Wiley & Sons Inc, 2013

Inhaltsangabe

THE HANDBOOK IS PART OF THE HANDBOOK OF REAGENTS FOR ORGANIC CHEMISTRY SERIES, AIMING AT COLLECTING ARTICLES ON A PARTICULAR THEME THAT INDIVIDUAL RESEARCHERS IN ACADEMIA OR INDUSTRY CAN USE ON A DAILY BASIS. THE HANDBOOK STARTS WITH A SECTION DISCUSSING THE MOST IMPORTANT ASPECTS OF HETEROARENE FUNCTIONALIZATION. THE INTRODUCTION IS FOLLOWED BY THE ALPHABETICAL LISTING OF THE MOST RELEVANT REAGENTS DRAWN FROM THE EROS DATABASE. THE EDITOR, ANDRÉ CHARETTE FROM THE UNIVERSITY OF MONTREAL, HAS SELECTED 120 REAGENT DESCRIPTIONS, MANY OF THEM UPDATED WITH HETEROARENE–SPECIFIC REACTIONS FOR THIS HANDBOOK. FOLLOWING THE STANDARD FORMAT FOR EROS, EACH ARTICLE CONTAINS AN OVERVIEW OF THE SYNTHESIS AND PHYSICAL PROPERTIES OF THE REAGENTS OR CATALYST, CONDITIONS FOR ITS STORAGE, AND PURIFICATION METHODS. GIVEN THE IMPORTANCE OF HETEROARENES IN BIOLOGY AND ESPECIALLY IN MEDICINAL CHEMISTRY, A HANDBOOK THAT FOCUSES EXCLUSIVELY ON HETEROARENE FUNCTIONALIZATION HAS BEEN LONG OVERDUE. THIS HANDBOOK WILL HAVE A BROAD APPEAL TO MANY INDIVIDUALS ENGAGED IN THE AREA OF MEDICINAL CHEMISTRY, FINE CHEMICAL SYNTHESIS AND INDUSTRIAL–SCALE CHEMISTRY. KEY FEATURES: BUILDS ON THE SUCCESS OF THE PREVIOUSLY PUBLISHED HANDBOOKS OF REAGENTS FOR ORGANIC SYNTHESIS COMPARES THE NUMEROUS NEW C–H FUNCTIONALIZATION REACTIONS THAT HAVE BEEN DEVELOPED IN THE PAST DECADE HETEROARENE FUNCTIONALIZATION IS WIDELY USED IN THE DEVELOPMENT OF PHARMACEUTICALS AND OTHER BIOACTIVE COMPOUNDS CONTAINS LISTINGS OF SECONDARY REAGENTS FOR WHICH MORE INFORMATION IS AVAILABLE IN THE ONLINE EDITION

Über diesen Titel

Reseña del editor:

The Handbook is part of the Handbook of Reagents for Organic Chemistry series, aiming at collecting articles on a particular theme that individual researchers in academia or industry can use on a daily basis. The Handbook starts with a section discussing the most important aspects of heteroarene functionalization. The introduction is followed by the alphabetical listing of the most relevant reagents drawn from the EROS database. The Editor, Andre Charette from the University of Montreal, has selected 120 reagent descriptions, many of them updated with heteroarene-specific reactions for this Handbook. Following the standard format for EROS, each article contains an overview of the synthesis and physical properties of the reagents or catalyst, conditions for its storage, and purification methods. Given the importance of heteroarenes in biology and especially in medicinal chemistry, a Handbook that focuses exclusively on heteroarene functionalization has been long overdue. This Handbook will have a broad appeal to many individuals engaged in the area of medicinal chemistry, fine chemical synthesis and industrial-scale chemistry. Key features: * Builds on the success of the previously published Handbooks of Reagents for Organic Synthesis * Compares the numerous new C-H functionalization reactions that have been developed in the past decade * Heteroarene functionalization is widely used in the development of pharmaceuticals and other bioactive compounds * Contains listings of secondary reagents for which more information is available in the online edition

Contraportada:

Syntheses requiring high material throughput are made even more challenging when targeting pure enantiomers. Asymmetric reactions employing chiral catalysts and prochiral substrates are highly attractive because one molecule of catalyst generates a multitude of chiral progeny. Modern synthesis is rapidly evolving by creating new transformations that employ C-H bonds as the locus for specific functionalization. This Handbook presents short, informative articles on some 80 reagents that summarize the current state-of-the-art using chiral strategies efficiently to increase molecular complexity. These transformations include arene and heteroarene functionalizations, the introduction of heteroatoms, the formation of chiral centers, rings and multiple bonds, and enantiogenesis.

All the information compiled in this volume is also available in electronic format on Wiley InterScience. The electronic Encyclopedia of reagents for Organic Synthesis (e-EROS)) includes all the reagents described here plus many more reagents of other types and for other uses. e-EROS offers text and structure search and is updated twice a year. For More information visit: http: //www.mrw.interscience.wiley.com/eros/

Über diese Auflage

• Verlag: John Wiley & Sons Inc
• Erscheinungsdatum: 2013
• ISBN 10: 1119953278
• ISBN 13: 9781119953272
• Einband: Tapa dura
• Anzahl der Seiten: 782
• Herausgeber: Fuchs Philip L.