Verwandte Artikel zu Monoclonal Antibody Therapy of Human Cancer: 38 (Development...
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KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system. Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system.
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- VerlagSpringer
- Erscheinungsdatum2013
- ISBN 10 1461296420
- ISBN 13 9781461296423
- EinbandTapa blanda
- Anzahl der Seiten180
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Monoclonal Antibody Therapy of Human Cancer (Developments in Oncology) by Foon, Kenneth A. [Paperback ]
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Monoclonal Antibody Therapy of Human Cancer (Developments in Oncology, 38)
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Monoclonal Antibody Therapy of Human Cancer
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Monoclonal Antibody Therapy of Human Cancer
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Springer US Feb 2012
(2012)
ISBN 10: 1461296420
ISBN 13: 9781461296423
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Buchbeschreibung Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system. Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system. 180 pp. Englisch. Bestandsnummer des Verkäufers 9781461296423
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Monoclonal Antibody Therapy of Human Cancer
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Buchbeschreibung Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - KENNETH A. FOON and ALTON C. MORGAN, JR. Passive immunotherapy using heteroantisera for the treatment of cancer in animals and humans has been studied for over 50 years. Attempts have been made to treat animal tumors with sera from immunized syngeneic, allogeneic, or xenogeneic animals. A number of studies of passive immunotherapy using heterologous antisera in humans have also been performed. These studies have generally been attempted in patients with large tumor burdens, and as would be expected, results have been transient at best. A wide variety of solid tumors as well as leukemias and lym phomas have been treated with antisera raised in sheep, horses, rabbits, and goats. Problems such as anaphylaxis, serum sick ness, and severe cytopenias have been encountered with these antisera. There are a number of potential mechanisms by which unconju gated antibodies might be cytotoxic to tumor cells. Antibodies bound to the cell surface membrane of tumor cells may lead to cell lysis by complement-dependent or antibody-dependent cellu lar cytotoxicity. Circulating tumor cells bound by antibody may be more susceptible to phagocytosis by the reticuloendothelial system. Antibody bound to the cell surface membrane of tumor cells may enhance immunogenicity of the tumor cell leading to activation of the host's immune system. Bestandsnummer des Verkäufers 9781461296423
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Monoclonal Antibody Therapy of Human Cancer
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Buchbeschreibung Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. 1. Monoclonal Antibody Therapy of Cancer: Parameters Which Affect the Efficacy of Immunotoxins.- 2. Design and Development of Drug-Monoclonal Antibody 791T/36 Conjugate for Cancer Therapy.- 3. Monoclonal Antibodies Directed Towards Growth-Related Receptors . Bestandsnummer des Verkäufers 4192137
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Monoclonal Antibody Therapy of Human Cancer
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(2012)
ISBN 10: 1461296420
ISBN 13: 9781461296423
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Buchbeschreibung Paperback / softback. Zustand: New. This item is printed on demand. New copy - Usually dispatched within 5-9 working days. Bestandsnummer des Verkäufers C9781461296423
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