Polyglutamine Disorders (Advances in Experimental Medicine and Biology, Band 1049) - Softcover

Buch 345 von 544: Advances in Experimental Medicine and Biology
 
9783319891033: Polyglutamine Disorders (Advances in Experimental Medicine and Biology, Band 1049)
Softcover
ISBN 10: 3319891030 ISBN 13: 9783319891033
Verlag: Springer, 2019

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Über die Autorin bzw. den Autor

Clevio Nobrega Ph.D. and Luis Pereira de Almeida Ph.D.
University of Coimbra, Center for Neurosciences and Cell Biology, FMUC, Coimbra, Portugal

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This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression.

Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17).

The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.


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Verlag
Springer
Erscheinungsdatum
2019
Sprache
Englisch
ISBN 10 
3319891030
ISBN 13 
9783319891033
Einband
Taschenbuch
Anzahl der Seiten
480
Herausgeber
Nóbrega Clévio, Pereira De Almeida Luís
Kontakt zum Hersteller
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Deutschland

Weitere beliebte Ausgaben desselben Titels

9783319717784: Polyglutamine Disorders (Advances in Experimental Medicine and Biology, 1049, Band 1049)

Vorgestellte Ausgabe

ISBN 10:  3319717782 ISBN 13:  9783319717784
Verlag: Springer, 2018
Hardcover