Somatic Diversification of Immune Responses (Vol 229) (Current Topics in Microbiology and Immunology) - Hardcover

Hardcover

ISBN 10: 3540636080 ISBN 13: 9783540636083

Verlag: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 1997

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Reseña del editor:

Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo­ ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re­ markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec­ tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.

Reseña del editor:

This volume offers an overview of some important aspects of immune function. V(D)J hypermutation drives the somatic evolution of antigen-reactive B lymphocytes and is necessary for the generation of protective humoral immunity. The mechanism of this hypermutation remains enigmatic, although several seemingly mutually exclusive models have been proposed. Perhaps surprisingly, this volume demonstrates that there is no consensus on the major problems in the area of somatic diversification; the same experimental data has been interpreted in different ways by various authors. This lack of consensus reveals that the field of somatic diversification, from top to bottom, is an exciting area of immunology that stubbornly keeps its secrets to itself.

Über diese Auflage

• Verlag: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Erscheinungsdatum: 1997
• ISBN 10: 3540636080
• ISBN 13: 9783540636083
• Einband: Tapa dura
• Anzahl der Seiten: 231
• Herausgeber: Flajnik M., Kelsoe G.