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Taschenbuch. Zustand: Neu. Somatic Diversification of Immune Responses | Garnett Kelsoe (u. a.) | Taschenbuch | Current Topics in Microbiology and Immunology | x | Englisch | 2011 | Springer | EAN 9783642719868 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer Berlin Heidelberg, 2011
ISBN 10: 3642719864 ISBN 13: 9783642719868
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.
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Sprache: Englisch
Verlag: Springer Berlin Heidelberg Dez 2011, 2011
ISBN 10: 3642719864 ISBN 13: 9783642719868
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem. 240 pp. Englisch.
Sprache: Englisch
Verlag: Springer Berlin Heidelberg, 2011
ISBN 10: 3642719864 ISBN 13: 9783642719868
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In den WarenkorbZustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. As knowledge from experimentation accumulates, we begin to have a somewhat clearer picture of the muation/conversion process(es). This volume takes one step forward in the analysis of somatic diversification.Discovery of the mechanism for V(D)J hypermut.
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Sprache: Englisch
Verlag: Springer, Springer Dez 2011, 2011
ISBN 10: 3642719864 ISBN 13: 9783642719868
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 240 pp. Englisch.