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Airways Smooth Muscle: Development, and Regulation of Contractility: Vol 2 (Respiratory Pharmacology and Pharmacotherapy) - Hardcover
Inhaltsangabe
Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser- vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur- ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) What determines the density and pattern of inner- vation at reaching the effector? iii) How do the nerves survive and maintain their position once established? iv) What factors influence neurochemical differentiation such that genetically multipotential neu- rones are triggered to synthesize one or combinations of neurotransmit- ters? v) What influence do nerves have on the structure, function and receptor expression of their effector cells? vi) How do diseases interrupt these processes? - see [1].
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Reseña del editor
Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) What determines the density and pattern of inner vation at reaching the effector? iii) How do the nerves survive and maintain their position once established? iv) What factors influence neurochemical differentiation such that genetically multipotential neu rones are triggered to synthesize one or combinations of neurotransmit ters? v) What influence do nerves have on the structure, function and receptor expression of their effector cells? vi) How do diseases interrupt these processes? - see [1].
Reseña del editor
The emphasis in this second volume in a series of research monographs is on the growth and development of airways smooth muscle and its regulation. It also addresses the role of nerves and other physiological factors responsible for regulating contractility. The contributors review the latest research data and emerging themes in the field. Aspects discussed include trophic factors and the control of smooth muscle development, cell-to-cell coupling, electrophysiology, voltage-dependent calcium channels, and the effects of ageing on contractility. This reference should provide a useful source of information which will benefit researchers in physiology, pharmacology, anatomy and developmental biology, as well as clinicians.
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- VerlagBirkhauser Verlag AG
- Erscheinungsdatum1994
- ISBN 10 3764350113
- ISBN 13 9783764350116
- EinbandTapa dura
- SpracheEnglisch
- Anzahl der Seiten432
- HerausgeberRaeburn David, Giembycz M. A.
- Kontakt zum HerstellerNicht verfügbar
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Airways Smooth Muscle: Development, and Regulation of Contractility: Development and Regulation of Contractility (Respiratory Pharmacology and Pharmacotherapy)
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Airways Smooth Muscle: Development, and Regulation of Contractility: Development and Regulation of Contractility (Respiratory Pharmacology and Pharmacotherapy)
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