Functional Genetics and Psychiatric Disorders: An Exploration of Functional Genetic Variants in Candidate Genes for Psychiatric Disorders - Softcover
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Drug addiction is a chronic disorder characterized by compulsive drug seeking and taking despite serious negative consequences. Association studies have identified a number of candidate genes harboring variants associated with susceptibility to addiction, but the causative variants frequently remain unknown. A solution to the challenge of identifying causative variants is the thorough characterization of functional genetic polymorphisms and their effects on regulation of candidate genes. I focused on candidate genes for drug addiction (ARRB2, DRD2, and DRD3) and made some novel and significant findings: The effects of two intronic SNPs in the human dopamine receptor D2 (DRD2) gene, previously shown to alter DRD2 alternative splicing, were confirmed in human brain autopsy tissues obtained from a population of cocaine abusers and controls. The same SNPs were significantly associated with cocaine abuse. The results of this study contribute to our understanding of the functional genetic variation in important candidate genes and have the potential to improve the prevention and treatment of drug addiction and other psychiatric disorders.
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Über die Autorin bzw. den Autor
Robert Moyer ha conseguito il dottorato di ricerca in Farmacologia molecolare, Farmacogenomica e Terapeutica presso la Ohio State University nel 2010. Il Dr. Wolfgang Sadee è Felts Mercer Professor di Medicina e Farmacologia e Presidente del Dipartimento di Farmacologia della Ohio State University.
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Functional Genetics and Psychiatric Disorders
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LAP LAMBERT Academic Publishing Jun 2011, 2011
ISBN 10: 3844384162
ISBN 13: 9783844384161
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Drug addiction is a chronic disorder characterized by compulsive drug seeking and taking despite serious negative consequences. Association studies have identified a number of candidate genes harboring variants associated with susceptibility to addiction, but the causative variants frequently remain unknown. A solution to the challenge of identifying causative variants is the thorough characterization of functional genetic polymorphisms and their effects on regulation of candidate genes. I focused on candidate genes for drug addiction (ARRB2, DRD2, and DRD3) and made some novel and significant findings: The effects of two intronic SNPs in the human dopamine receptor D2 (DRD2) gene, previously shown to alter DRD2 alternative splicing, were confirmed in human brain autopsy tissues obtained from a population of cocaine abusers and controls. The same SNPs were significantly associated with cocaine abuse. The results of this study contribute to our understanding of the functional genetic variation in important candidate genes and have the potential to improve the prevention and treatment of drug addiction and other psychiatric disorders. 96 pp. Englisch. Bestandsnummer des Verkäufers 9783844384161
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Functional Genetics and Psychiatric Disorders
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ISBN 10: 3844384162
ISBN 13: 9783844384161
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Moyer RobertDr. Robert Moyer earned his Ph.D. in Molecular Pharmacology, Pharmacogenomics, and Therapeutics from The Ohio State University in 2010. Dr. Wolfgang Sadee is Felts Mercer Professor of Medicine and Pharmacology and Chair . Bestandsnummer des Verkäufers 5475940
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Functional Genetics and Psychiatric Disorders
Verlag:
LAP LAMBERT Academic Publishing Jun 2011, 2011
ISBN 10: 3844384162
ISBN 13: 9783844384161
Neu
Taschenbuch
Anbieter: buchversandmimpf2000, Emtmannsberg, BAYE, Deutschland
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Drug addiction is a chronic disorder characterized by compulsive drug seeking and taking despite serious negative consequences. Association studies have identified a number of candidate genes harboring variants associated with susceptibility to addiction, but the causative variants frequently remain unknown. A solution to the challenge of identifying causative variants is the thorough characterization of functional genetic polymorphisms and their effects on regulation of candidate genes. I focused on candidate genes for drug addiction (ARRB2, DRD2, and DRD3) and made some novel and significant findings: The effects of two intronic SNPs in the human dopamine receptor D2 (DRD2) gene, previously shown to alter DRD2 alternative splicing, were confirmed in human brain autopsy tissues obtained from a population of cocaine abusers and controls. The same SNPs were significantly associated with cocaine abuse. The results of this study contribute to our understanding of the functional genetic variation in important candidate genes and have the potential to improve the prevention and treatment of drug addiction and other psychiatric disorders.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 96 pp. Englisch. Bestandsnummer des Verkäufers 9783844384161
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Functional Genetics and Psychiatric Disorders : An Exploration of Functional Genetic Variants in Candidate Genes for Psychiatric Disorders
Verlag:
LAP LAMBERT Academic Publishing, 2011
ISBN 10: 3844384162
ISBN 13: 9783844384161
Neu
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Drug addiction is a chronic disorder characterized by compulsive drug seeking and taking despite serious negative consequences. Association studies have identified a number of candidate genes harboring variants associated with susceptibility to addiction, but the causative variants frequently remain unknown. A solution to the challenge of identifying causative variants is the thorough characterization of functional genetic polymorphisms and their effects on regulation of candidate genes. I focused on candidate genes for drug addiction (ARRB2, DRD2, and DRD3) and made some novel and significant findings: The effects of two intronic SNPs in the human dopamine receptor D2 (DRD2) gene, previously shown to alter DRD2 alternative splicing, were confirmed in human brain autopsy tissues obtained from a population of cocaine abusers and controls. The same SNPs were significantly associated with cocaine abuse. The results of this study contribute to our understanding of the functional genetic variation in important candidate genes and have the potential to improve the prevention and treatment of drug addiction and other psychiatric disorders. Bestandsnummer des Verkäufers 9783844384161
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Functional Genetics and Psychiatric Disorders | An Exploration of Functional Genetic Variants in Candidate Genes for Psychiatric Disorders
Verlag:
LAP LAMBERT Academic Publishing, 2011
ISBN 10: 3844384162
ISBN 13: 9783844384161
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Taschenbuch. Zustand: Neu. Functional Genetics and Psychiatric Disorders | An Exploration of Functional Genetic Variants in Candidate Genes for Psychiatric Disorders | Robert Moyer (u. a.) | Taschenbuch | 96 S. | Englisch | 2011 | LAP LAMBERT Academic Publishing | EAN 9783844384161 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 106913214
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Functional Genetics and Psychiatric Disorders: An Exploration of Functional Genetic Variants in Candidate Genes for Psychiatric Disorders
Verlag:
LAP LAMBERT Academic Publishing, 2011
ISBN 10: 3844384162
ISBN 13: 9783844384161
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