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Solid Self Micron Emulsifying Drug Delivery System of Rosuvastatin: Noval Drug Delivery System (SSMEDDS) - Rosuvastatin Calcium - Softcover

Vishwakarma, Amit

 
9786139912087: Solid Self Micron Emulsifying Drug Delivery System of Rosuvastatin: Noval Drug Delivery System (SSMEDDS) - Rosuvastatin Calcium
Softcover
ISBN 10: 6139912083 ISBN 13: 9786139912087
Verlag: LAP LAMBERT Academic Publishing, 2020

Inhaltsangabe

The objective of present research work was to develop a self-emulsifying drug delivery system of Rosuvastatin Calcium (RC) for increasing its solubility, and oral bioavailability. Solubility of RC was determined in various vehicles. Oil, Surfactant and Cosurfactant were selected based on the solubility and HLB (Hydrophilic lipophilic balance) value. To identify the microemulsion existing zone Pseudo-ternary phase diagrams were constructed. Solubility analysis was also done for optimization of formulation. The optimised microemulsion formulation was evaluated for Powder X-Ray Diffraction (XRD), SEM (Scanning electron microscopy) analysis, globule size, zeta potential and phase separation study. Average globule size and zeta potential of the optimized microemulsion formulation were found to be 30 nm, and -11.5 mV, respectively. The viscosity and conductivity data indicated that the microemulsion was of the o/w type.The solubility of RC was successfully enhanced up to 82.32%. Percent drug release at the end of 60 min was found to be 76.74 %. The solubility of Rosuvastatin Calcium was significantly enhanced after formulating into self-emulsify microemulsion.

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Über die Autorin bzw. den Autor

-Amit Kumar VishwakarmaMaster of Pharmacy in Pharmaceutics from Amity University Uttar Pradesh, Lucknow.7 publication in indexed journals.Professional Experience6 yrs of rich experience in diabetes and metabolism therapy area while working in Medical Affairs and Medico Marketing role in large multinational companies.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2020
Sprache
Englisch
ISBN 10 
6139912083
ISBN 13 
9786139912087
Einband
Taschenbuch
Anzahl der Seiten
92
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Editions Muse
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