Extraction and Crystal Structure of Physalin B

Yang, Yan-jun

ISBN 10: 3330082232 / ISBN 13: 9783330082236

Verlag: LAP LAMBERT Academic Publishing, 2017

60 pages. 8.66x5.91x0.14 inches. In Stock. Bestandsnummer des Verkäufers __3330082232

Inhaltsangabe:

Physalin B (C28H32O9), a main active physalin of Physalis angulata L was isolated from the whole plant of Physalis angulata L, and characterized by X-ray diffraction analysis. It crystallizes in the monoclinic system, space group P2(1) with C28H32O9, a = 12.4996(2), b = 14.35620(10), c = 14.75190(10)Å, V = 2607.97(5)Å3, Z = 4,Dc = 1.382mg/cm3, Mr = 542.56, F(000) = 1152, and μ= 0.870 mm-1. The final R = 0.0389 and wR = 0.1037 for 47670 observed reflections (I > 2ο(I)). The rigid molecule consists of eight fused rings involving two lactones.. There are two C28H32O9 molecules in an symmetric unit, and the title compound is stacked into a 3D layer structure through hydrogen bonds.In the 5-20μmol/L range, physalin B can significantly inhibit the secretion of inflammatory cytokines TNF-α and IL-6 on RAW264.7 cells. The results suggest that physalin B has anti-inflammatory activity in vitro.

Über die Autorin bzw. den Autor: Yang Yanjun¿professor of pharmacy, involved in natural active drug research about more than 25 years, mainly ficused on high-active drug structures and new structure types, has discovered 4 new compounds, got 5 invention patents and published more than 40 research papers.

Bibliografische Details

Titel: Extraction and Crystal Structure of Physalin...
Verlag: LAP LAMBERT Academic Publishing
Erscheinungsdatum: 2017
Einband: Paperback
Zustand: Brand New