Normal and Binding Mode Analysis of Breast Cancer Resistance Protein: Structural Bioinformatics of BCRP

Kumar, Prasanth, Patel, Saumya, Pandya, Himanshu

ISBN 10: 3659153125 / ISBN 13: 9783659153129

Verlag: LAP LAMBERT Academic Publishing, 2012

Beschreibung

Like New. Bestandsnummer des Verkäufers ERICA80036591531256

Bibliografische Details

Titel: Normal and Binding Mode Analysis of Breast ...

Verlag: LAP LAMBERT Academic Publishing

Erscheinungsdatum: 2012

Einband: paperback

Zustand: Like New

Art des Buches: book

Über diesen Titel

Inhaltsangabe:

Breast Cancer Resistance Protein (BCRP) is a membrane-associated protein and a member of the the super family of ATP-binding cassette (ABC) transporters known to confer multidrug resistance (MDR) to a number of important anticancer agent and play an important function in governing drug absorption. This book deals about the development of homology model of BCRP and its correspondence with experimentally known topology. This study also helped to understand the protein dynamics of BCRP through coarse-grained normal mode analysis. Structural analysis of substrate specificity bestowed by specific amino acids and its interaction with various synthetic and natural compounds provided clues of developing an efficient inhibitor.