Synthesis & Study Biological Activity of New Phthalimide Derivatives | Study the biological activity of new Mannich bases derived from phthalimide

Asaad Hashim (u. a.)

ISBN 10: 6200499683 / ISBN 13: 9786200499684

Verlag: LAP LAMBERT Academic Publishing, 2020

Synthesis & Study Biological Activity of New Phthalimide Derivatives | Study the biological activity of new Mannich bases derived from phthalimide | Asaad Hashim (u. a.) | Taschenbuch | 92 S. | Englisch | 2020 | LAP LAMBERT Academic Publishing | EAN 9786200499684 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 117948660

Inhaltsangabe:

The research involves synthesis of some new aminoacetylenic derivatives of phthalimide. The phthalimide in this study served as starting material and was converted to the corresponding potassium salt through reaction with potassium hydroxide. The alkylation of the imide salt with the propargyl bromide afforded the desired N-propynylphthalimide (A1). The Mannich reaction (three componenets in one pot reaction) was carried out by using the N-propynylphthalimide (A1), formaldehyde, benzaldehyde and some of its derivatives, as well as morpholine or piperidine which are taken as secondary amines, in the presence of peroxide free dioxane and a catalytic amount of cuprous chloride under various basic, acidic, solvent and temperature conditions, resulted in formation of a novel aminoacetylenic Isoindoline-1,3-dione derivatives (A2-A12).

Über die Autorin bzw. den Autor: Asaad Hashim received BSc degree in Chemistry in 2002 and MSc in Chemistry in 2012. ¿urrently he is a PhD student.

Bibliografische Details

Titel: Synthesis & Study Biological Activity of New...
Verlag: LAP LAMBERT Academic Publishing
Erscheinungsdatum: 2020
Einband: Taschenbuch
Zustand: Neu