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Paperback. Zustand: New. Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).…

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Paperback. Zustand: Brand New. 75 pages. 8.94x5.98x0.24 inches. In Stock.

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162 pp.; 21.5 cm.; sewn bound; duotone; edition size unknown; unsigned and unnumbered; offset-printed; Catalogue of conversations held as part of "Art Basel Conversations," Art Basel Miami Beach, Dec. 2 - 5, 2004 and Art Basel 35, Basel, Switzerland, June 16 - June 21, 2004. Include speakers biographies and directory as well as selected transcripts of conversations. Speakers include John Baldessari, Ute Meta Bauer, Daniel Birnbaum, Stefano Boeri, Paloma Botín, Roger M. Buergel, Janet Cardiff, Catherine David, Lisa Dennison, Trisha Donnelly, Olafur Eliasson, David Elliott, João Fernandes, Antoine de Galbert, Liam Gillick, Zaha Hadid, Kathy Halbreich, Yuko Hasegawa, Hans-Michael Herzog, Marieluise Hessel, Erika Hoffmann, Jens Hoffmann, Jenny Holzer, Kasper König, Rem Koolhaas, Jeff Koons, Gunnar B. Kvaran, Wilfried Lentz, Rosa Martinez, Ivo Costa Mesquita, Paul Morrissey, Ernesto Neto, Hans Ulrich Obrist, Adriano Pedrosa, Anne Philbin, Terence Riley, James Rondeau, Beatrix Ruf, Ricardo Sardenberg, Linda Shearer, Bruce Sterling, Juan Vergez, Mercedes Vilardell, Francesca von Habsburg, Sheena Wagstaff, and Billie Milam Weisman Very Good. Light wear to covers. Contents clean and unmarked. Due to large size and weight additional shipping charges will be required for international orders.…

Taschenbuch. Zustand: Neu. Neuware - Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).…

Kartoniert / Broschiert. Zustand: New. Inhaltsverzeichnis1.Structural biology and mechanism of activation of EGFR 2. EGFR-associated oncogenesis 3. Tyrosine kinase inhibitors (TKIs) as targeted treatment for EGFR-mutant NSCLC 4. EGFR-TKIs as adjuvant or neoadjuvant therapy.

Paperback. Zustand: New. Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).…

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Paperback. Zustand: New. Brand new book, sourced directly from publisher. Dispatch time is 24-48 hours from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely.

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Paperback. Zustand: Brand New. 4th edition. 516 pages. 9.00x7.50x1.25 inches. In Stock.

Paperback. Zustand: New. 4th. Linear Algebra: Algorithms, Applications, and Techniques, Fourth Edition offers a modern and algorithmic approach to computation while providing clear and straightforward theoretical background information. The book guides readers through the major applications, with chapters on properties of real numbers, proof techniques, matrices, vector spaces, linear transformations, eigen values, and Euclidean inner products. Appendices on Jordan canonical forms and Markov chains are included for further study. This useful textbook presents broad and balanced views of theory, with key material highlighted and summarized in each chapter. To further support student practice, the book also includes ample exercises with answers and hints.…

Zustand: New. Introduces deductive reasoning and helps the reader develop a facility with mathematical proofs Provides a balanced approach to computation and theory by offering computational algorithms for finding eigenvalues and eigenvectors O.

Paperback. Zustand: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.…

Paperback. Zustand: New. 4th. Linear Algebra: Algorithms, Applications, and Techniques, Fourth Edition offers a modern and algorithmic approach to computation while providing clear and straightforward theoretical background information. The book guides readers through the major applications, with chapters on properties of real numbers, proof techniques, matrices, vector spaces, linear transformations, eigen values, and Euclidean inner products. Appendices on Jordan canonical forms and Markov chains are included for further study. This useful textbook presents broad and balanced views of theory, with key material highlighted and summarized in each chapter. To further support student practice, the book also includes ample exercises with answers and hints.…

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