Felix rietmann (5 Ergebnisse)
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Taschenbuch. Zustand: Neu. ClC-channels and etoposide resistance | An experimental study of the neuroendocrine tumour cell line LCC-18 | Felix Rietmann | Taschenbuch | 60 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838125305 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengeriche…r Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Drug resistance constitutes a major challenge in the treatment of metastatic neuroendocrine cancer. Chemotherapeutic regimes for these tumours employ weak-base drugs such as etoposide. Especially for this medication, a mechanism of re…sistance was suggested that linked increased acidification of intracellular compartments to the evolution of drug resistance. So far, most research groups have focused on the role of the driving force behind compartmental acidification, the vacuolar H+-ATPase, in drug resistance. However, chloride channels of the ClC-family also play a pivotal role in the pH homeostasis of cellular organelles, and recently the first evidence for a potential role of ClC-3 in drug resistance was given. Following this finding, this work aims to further elucidate the role of ClC-channels and compartmental acidification in the evolution of etoposide resistance. In this context it focuses on the question of whether an up-regulation of intracellular ClC-channels can be observed as a cellular response to chemotherapeutic drugs and whether it will entail increased compartmental acidity and thus contribute to the evolution of drug resistance in vitro. 60 pp. Englisch.
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Verlag: Südwestdeutscher Verlag für Hochschulschriften, 2011
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Rietmann FelixFelix Rietmann, Dr. med., has studied medicine in Berlin,Toulouse and Paris, andHistory of Science, Medicine and Technology in London. He iscurrently working as a paediatrician at the CHUV i…n Lausanne, Switzerland. His .
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Verlag: Südwestdeutscher Verlag Für Hochschulschriften Mär 2011, 2011
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Drug resistance constitutes a major challenge in the treatment of metastatic neuroendocrine cancer. Chemotherapeutic regimes for these tumours employ weak-base drugs such as etoposide. Especially for this medication, a mechanism of resist…ance was suggested that linked increased acidification of intracellular compartments to the evolution of drug resistance. So far, most research groups have focused on the role of the driving force behind compartmental acidification, the vacuolar H+-ATPase, in drug resistance. However, chloride channels of the ClC-family also play a pivotal role in the pH homeostasis of cellular organelles, and recently the first evidence for a potential role of ClC-3 in drug resistance was given. Following this finding, this work aims to further elucidate the role of ClC-channels and compartmental acidification in the evolution of etoposide resistance. In this context it focuses on the question of whether an up-regulation of intracellular ClC-channels can be observed as a cellular response to chemotherapeutic drugs and whether it will entail increased compartmental acidity and thus contribute to the evolution of drug resistance in vitro.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 60 pp. Englisch.
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Drug resistance constitutes a major challenge in the treatment of metastatic neuroendocrine cancer. Chemotherapeutic regimes for these tumours employ weak-base drugs such as etoposide. Especially for this medication, a mechanism of resista…nce was suggested that linked increased acidification of intracellular compartments to the evolution of drug resistance. So far, most research groups have focused on the role of the driving force behind compartmental acidification, the vacuolar H+-ATPase, in drug resistance. However, chloride channels of the ClC-family also play a pivotal role in the pH homeostasis of cellular organelles, and recently the first evidence for a potential role of ClC-3 in drug resistance was given. Following this finding, this work aims to further elucidate the role of ClC-channels and compartmental acidification in the evolution of etoposide resistance. In this context it focuses on the question of whether an up-regulation of intracellular ClC-channels can be observed as a cellular response to chemotherapeutic drugs and whether it will entail increased compartmental acidity and thus contribute to the evolution of drug resistance in vitro.
