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Zustand: new.

Zustand: New.

Zustand: new.

Zustand: New. 1st ed. 2021 edition NO-PA16APR2015-KAP.

Hardcover. Zustand: new. Hardcover. Skin accounts for approximately 15% of an adults total body weight, with a surface of about 2m2. It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals.The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Skin accounts for approximately 15% of an adult's total body weight, with a surface of about 2m . It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals.The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient. …

Zustand: New.

Hardcover. Zustand: Brand New. 221 pages. 9.25x6.10x0.79 inches. In Stock.

Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Skin accounts for approximately 15% of an adult's total body weight, with a surface of about 2m . It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals.The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient. …

paperback. Sobre a obra Boa-fé no Contrato de Seguro - 1ª ED - 2024 A boa-fé é inerente ao contrato de seguro, sendo reconhecida desde as origens do tipo na prática mercantil até a contemporaneidade. Na presente obra, a autora explora a evolução deste conceito, na sua manifestação  uberrima fides ,  a exigir das partes, segurado e segurador, a observância da "mais estrita boa-fé e veracidade".                 Este livro oferece uma investigação aprofundada sobre a boa-fé no direito dos seguros brasileiro, analisando a sua importância e aplicação à luz do  Código Civil  e da experiência  jurídica estrangeira.                 Discute-se a necessidade de uma  boa-fé  qualificada, que abrange não apenas o dever de informar, mas também a proteção da confiança mútua entre segurado e segurador.                 Dividida em duas partes, a obra inicia com um estudo histórico-comparado, examinando a formação e o desenvolvimento do conceito de boa-fé no direito dos seguros  francês, alemão e inglês , e a sua influência no  direito brasileiro .                 Na segunda parte, a autora analisa a função estrutural da boa-fé no contrato de seguro, abordando a natureza  uberrima fides  do tipo, a sua relação com o princípio da confiança e as implicações práticas dessa característica.                 Com uma abordagem crítica e contemporânea, a obra busca responder questões fundamentais sobre o papel da boa-fé no contrato de seguro no sistema jurídico atual, desafiando a ideia de que a  uberrima fides   se tornou meramente retórica. …

Paperback. Sobre a obra Seguros e Responsabilidade Civil - 1ª Ed - 2024 "A responsabilidade civil é um pilar do sistema jurídico, estabelecendo as bases para a justa reparação de danos causados a terceiros. Por outro lado, o seguro desempenha um papel crucial na gestão de riscos, oferecendo proteção financeira e promovendo confiança nas atividades econômicas em geral. A combinação desses dois domínios em uma única obra é uma iniciativa louvável e oportuna. Os artigos compilados neste livro exploram uma ampla gama de questões que são essenciais para o entendimento da relação entre seguro e responsabilidade civil. Desde a análise do 'duty to defend' no Brasil até a complexa interface entre seguros e sistemas de inteligência artificial, os autores tratam com percuciência de vários tópicos que desafiam a reflexão jurídica contemporânea. Entre os temas abordados, encontram-se discussões cuidadosas acerca do princípio da boa-fé objetiva na perspectiva do seguro de responsabilidade civil, o papel do seguro-garantia como instrumento de gerenciamento de riscos em contratos de infraestrutura, bem como os desafios e oportunidades apresentados pela inteligência artificial nos contratos de seguros. Além disso, este livro examina de perto a gestão de riscos nos contratos de seguros de riscos cibernéticos, uma área de crescente importância em um mundo cada vez mais digital e interconectado. Também oferece insights valiosos quanto ao papel vital do seguro de responsabilidade civil na resolução adequada de conflitos envolvendo profissionais da medicina e pacientes, entre outros temas de grande relevância que seria tedioso enumerar num prefácio que se destina a despertar o interesse dos leitores. À medida que o direito continua a evoluir e se adaptar às incessantes mudanças na sociedade e na técnica, o conhecimento sobre a interseção entre seguro e responsabilidade civil se torna mais crucial do que nunca, para alocar adequadamente os riscos e garantir a justa reparação dos danos causados pelo uso de tecnologias crescentemente complexas, invasivas e de elevado grau de risco. Esta obra coletiva contribui significativamente para essa compreensão e com certeza será referência valiosa para acadêmicos, juristas, profissionais do direito e estudantes". Trecho do prefácio de Ricardo Villas Bôas Cueva.…

Zustand: new. Questo è un articolo print on demand.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Skin accounts for approximately 15% of an adult's total body weight, with a surface of about 2m . It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals.The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient. 224 pp. Englisch.…

Zustand: New. Print on Demand.

Zustand: New. PRINT ON DEMAND.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Skin accounts for approximately 15% of an adult's total body weight, with a surface of about 2m . It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals.The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation.Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 224 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Skin accounts for approximately 15% of an adult's total body weight, with a surface of about 2m . It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals.The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient. 224 pp. Englisch.…

Zustand: New. Print on Demand.

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Skin accounts for approximately 15% of an adult's total body weight, with a surface of about 2m . It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals.The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation.Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 224 pp. Englisch. …

Zustand: New. PRINT ON DEMAND.