Ralph reisfeld (83 Ergebnisse)

Hardcover. vg/vg. Vol.2, Biological and Clinical Concepts. Medical; 4278.

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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The ever-expanding research on human cancer has resulted in numerous technical and conceptual advances during the last few years. Serological, structural, and biological char acterization of human melanoma constitutes one area of research that has received consid erable attention from researchers and clinicians and has generated new and exciting infor mation. In this volume, we have attempted to assemble work on topics that produced some of the most recent advances. We asked each author to describe and interpret his most cur rent research and, whenever possible, to compare and contrast it with work of other inves tigators in the field. We have been careful not to impose our viewpoints except in contri butions from our own laboratories, since we want to provide the reader with as many divergent and sometimes opposing viewpoints as feasible. Therefore, we have not been overly concerned with overlaps in some individual topics. We hope that this volume will provide the reader with a well-balanced overview of current problems and ideas in a par ticular area of cancer research. We wish to express our thanks to all contributors for their timely and very interesting manuscripts, and we sincerely hope that the reader will enjoy this volume and benefit as much from it as we did. R. A. Reisfeld S. Ferrone La Jolla ix Contents CHAPTER 1 Immunogenetics of Melanoma RONALD T. ACTON, CHARLES M. BALCH, BRUCE BUDOWLE, RODNEY C. P. Go, JEFFREY M. ROSEMAN, SENG-jAW SOONG, AND BRUCE O. BARGER 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .…

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Zustand: New. Editor(s): Sell, Stewart; Reisfeld, Ralph A. Series: Contemporary Biomedicine. Num Pages: 428 pages, biography. BIC Classification: MMF. Category: (G) General (US: Trade). Dimension: 235 x 155 x 23. Weight in Grams: 682. . 2011. Softcover reprint of the original 1st ed. 1985. Paperback. . . . . …

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Zustand: New. Monoclonal antibody technology from its earliest moments has offered revolutionary expectations for the diagnosis and treatment of cancer. Editor(s): Sell, Stewart; Reisfeld, Ralph A. Series: Contemporary Biomedicine. Num Pages: 428 pages, biography. BIC Classification: MJA; MJCL. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 234 x 156 x 25. Weight in Grams: 1770. . 1985. Hardback. . . . . …

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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - A variety of new cancer therapy modalities are discussed and evaluated in this book. It aims to demonstrate that the combination of classical chemo- and radiotherapy with new approaches in the field of immunotherapy can result in an improved treatment modality. Immunotherapy in this context consists of therapy with monoclonal antibodies, hematopoietic growth factors and other lymphokines. Results of early clinical trials with IL-2, GM-CSF and monoclonal antibodies against gastrointestinal tumors and melanoma are included. The progress in regional chemotherapy strategies, for example of the liver, is shown. In addition, the development of new chemotherapeutic agents with a different mode of action as well as better tolerability is presented. The use of hormones, such as LH-RH agonists, allows hormone-dependent tumors such as prostatic and breast cancer to be treated without strong adverse reactions. These recent findings give the reader insight into exciting therapeutic directions made possible by such combined, rather than single, modalities.…

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Information about histocompatibility antigens is expanding so rapidly that it is difficult to remain abreast of aB advances. In these volumes, we have made an effort to bring together the most current work on topics that have generated most of the re cent advances and discussions. We have asked each author to present and interpret his most current work, and we have judiciously refrained from imposing our own prejudices and viewpoints. Although there is obvious overlap in some individual topics, we have encouraged this to provide the reader with as many different and some times opposing viewpoints as possible. This approach will, we liope, give a broad overview of current ideas in the field. We wish to thank all contributors for their timely and exciting manu scripts, and we sincerely hope that the reader will benefit from these volumes. R. A. Reisfeld S. Ferrone La Jolla ix Contents I. Serology and Genetics Chapter 1 Studies of HLA-DR Antigens by Complement Fixation Jacques M. Colombani, Laurent Degos, Virginia Lepage, Helene Dastot, Muriel Reboul, and Pierre Lethielleux 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Material and Methods. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Results and Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3. 1. Screening for Anti-HLA-DR Complement-Fixing Sera . . . . . . . . 4 3. 2. Expression of HLA-A, -B and -DR Antigens on Peripheral Blood Lymphocytes during Phytohemagglutinin Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.3. Expression of HLA-A, -B and -DR Antigens on Peripheral Blood Lymphocytes during Concanavalin A Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 4.…

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Information about histocompatibility antigens is expanding so rapidly that of all advances. In these volumes, we have it is difficult to remain abreast made an effort to bring together the most current work on topics that have generated most of the recent advances and discussions. We have asked each author to present and interpret his most current work, and we have judiciously refrained from imposing our own prejudices and viewpoints. Although there is obvious overlap in some individual topics, we have encouraged this to provide the reader with as many different and some times opposing viewpoints as possible. This approach will, we hope, give a broad overview of current ideas in the field. We wish to thank all contributors for their timely and exciting manu scripts, and we sincerely hope that the reader will benefit from these volumes. R. A. Reisfeld S. Ferrone La Jolla vii Contents I. Role of Histocompatibility Antigens in Cell-Cell Interaction Chapter 1 Histocompatibility Antigens and the T-Cell Repertoire . . . . . . . . . . . . . . 3 Harald von Boehmer 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. H-2 Restriction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. H-2 Restriction of T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. B Cells Are Not H-2-Restricted . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 1. Influence on the T-Cell Repertoire . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 2. H-2-Gene Complementation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 3. TheB-Cell Repertoire Is Not Directly Influenced by H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Frequency of Cells Specific for Allogeneic H-2 Antigens . . . . . . . . 12 4. 1. Allospecific T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. 2. Allospecific B Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .…

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