U sunilchandra (52 Ergebnisse)

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Taschenbuch. Zustand: Neu. PHARMACOKINETIC STUDY AND RESIDUAL ANALYSIS OF CIPROFLOXACIN | IN DUAL PURPOSE CHICKEN | Sunilchandra U. (u. a.) | Taschenbuch | Englisch | 2022 | LAP LAMBERT Academic Publishing | EAN 9786204746555 | Verantwortliche Person für die EU: SIA OmniScriptum Publishing, Brivibas Gatve 197, 1039 RIGA, LETTLAND, customerservice[at]vdm-vsg[dot]de | Anbieter: preigu.…

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Zustand: Hervorragend. Zustand: Hervorragend | Sprache: Deutsch | Produktart: Bücher | Bei der Neupositionierung von Arzneimitteln geht es darum, neue therapeutische Verwendungszwecke für verfügbare und bestehende ältere Arzneimittel zu finden. In therapeutischer Hinsicht ist dies in den letzten Jahren zu einer beliebten und wirksamen Strategie geworden, um Arzneimittelmoleküle mit neuen pharmakologischen Wirkungen und therapeutischen Indikationen zu entdecken oder zu entwickeln. Die Strategie des Repurposing von Arzneimitteln ist effizient, wirtschaftlich und weniger zeitaufwändig und gilt als wirksame Alternative zum herkömmlichen Verfahren der Arzneimittelentdeckung. Mit der Entdeckung neuer biologischer Targets würde die Neupositionierung von Arzneimitteln die Erfolgsquote der Therapie maximieren. Die medikamentöse Vektorkontrolle ist eine neue Strategie, die die Verabreichung eines oralen insektiziden Medikaments an eine gefährdete menschliche Population beinhaltet, um den Insektenvektor bei der Blutspeisung zu töten und so die Vektorpopulation zu reduzieren und die Krankheitsübertragung zu verhindern. Die Tierarzneimittel der Isoxazolin-Kategorie, nämlich Fluralaner und Afoxolaner, wurden für die Bekämpfung von durch Vektoren übertragenen Krankheiten wie Malaria und Zika-Fieber eingesetzt. Veterinärmedizinische Antiparasitika aus der Gruppe der Benzimidazolcarbamate und halogenierten Salicylanilide wurden für die Bekämpfung von Krebserkrankungen beim Menschen umgewidmet und doppelt positioniert".…

Softcover. Zustand: gut. 2023. NEUPOSITIONIERUNG UND NEUAUSRICHTUNG VON THERAPEUTISCHEN MEDIKAMENTEN: UNTER BESONDERER BERÜCKSICHTIGUNG VON TIERARZNEIMITTELN In deutscher Sprache. pages.

Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Drug repurposing and repositioning is a process of identifying new therapeutic use (s) for the available and existing older drugs. Therapeutically, this has become a popular and effective strategy in recent years, in discovering or developing drug molecules.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present study was done to evaluate the pharmacokinetic parameters of ciprofloxacin following single dose of oral and i.v route of administration and estimating the residual level and withdrawal period. The safety evaluation on liver and kidney following multiple doses of ciprofloxacin orally in dual purpose chicken was done. The study was conducted in thirty day old Indian Rock-3 birds (n=210), a dual purpose chicken strain of White Plymouth Rock developed by Veterinary College, Bengaluru. Liquid Chromatography-tandem Mass Spectrometry, which provides superior specificity and sensitivity was used for the analytical study. For the pharmacokinetic study, the birds were divided into two experimental groups (n=15), Group I and Group II birds were administered with single dose of ciprofloxacin at 8 mg /kg, PO and 5 mg/kg, IV respectively for the pharmacokinetic study. The parameters were determined by non-compartmental analysis using PK solver software. For residue analysis and withdrawal period of ciprofloxacin experimental birds divided into two groups. 192 pp. Englisch.…

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The study was taken up to evaluate the pharmacological and toxicological property of Phaseolus lunatus (P. lunatus) plant. Phytochemical analysis revealed the presence of carbohydrates, proteins, saponins, alkaloids, flavonoids and phenolic compounds. The study was conducted to evaluate the in vivo anti-inflammatory property of the plant extract using carrageenan induced paw oedema and the extract at the doses of 400 and 600 mg/kg is having significant anti-inflammatory activity. In vivo analgesic activity was conducted by using acetic acid induced writhings as peripheral pain model and the extract at the doses 400 and 600 mg/kg showed significant analgesic activity. Acute oral and repeated dose 28 day oral toxicity studies of methanol extract was carried out in Wistar albino rats as per the OECD guidelines 423 and 407 respectively. In sub-acute oral toxicity dose levels of 200, 400 and 600 mg/kg were administered daily for 28 days and compared with the control rats. In both toxicity studies, no toxicity signs and mortality were observed. The MTD value was found to be more than 5 g/kg. No significant (p<0.05) changes in hematological parameters and biochemical parameters. …

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Nastoqschee issledowanie bylo prowedeno dlq ocenki farmakokineticheskih parametrow ciprofloxacina posle odnokratnoj dozy peroral'nogo i wnutriwennogo wwedeniq i ocenki ostatochnogo urownq i perioda wywedeniq. Byla prowedena ocenka bezopasnosti dlq pecheni i pochek posle mnogokratnogo priema ciprofloxacina peroral'no cyplqtam dwojnogo naznacheniq. Issledowanie prowodilos' na tridcatidnewnyh indijskih pticah porody Rok-3 (n=210), shtamme kur dwojnogo naznacheniq porody Belyj plimutrok, wywedennom w Veterinarnom kolledzhe Bengaluru. Dlq analiticheskogo issledowaniq ispol'zowalas' zhidkostnaq hromatografiq-tandemnaq mass-spektrometriq, kotoraq obespechiwaet prewoshodnuü specifichnost' i chuwstwitel'nost'. Dlq farmakokineticheskogo issledowaniq pticy byli razdeleny na dwe äxperimental'nye gruppy (n=15). Pticam I i II grupp wwodili odnokratnuü dozu ciprofloxacina w doze 8 mg/kg, PO i 5 mg/kg, IV sootwetstwenno dlq farmakokineticheskogo issledowaniq. Parametry byli opredeleny putem nekompartmentnogo analiza s ispol'zowaniem programmnogo obespecheniq PK solver. Dlq analiza ostatkow i perioda wywedeniq ciprofloxacina podopytnyh ptic razdelili na dwe gruppy. Gruppa I (n=10) sluzhila kontrolem, dlq standartizacii oborudowaniq. Gruppe II (n=80) ptic peroral'no wwodili ciprofloxacin. 168 pp. Russisch.…

Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. For the assessment of analgesic property of the plant extract using acetic acid induced writhing pain model in Wistar albino rats, which were divided into five groups (n=6 per group) with group I serving as control. Group II received paracetamol @ 100 mg/kg.…

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The present study was done to evaluate the pharmacokinetic parameters of ciprofloxacin following single dose of oral and i.v route of administration and estimating the residual level and withdrawal period. The safety evaluation on liver and kidney following multiple doses of ciprofloxacin orally in dual purpose chicken was done. The study was conducted in thirty day old Indian Rock-3 birds (n=210), a dual purpose chicken strain of White Plymouth Rock developed by Veterinary College, Bengaluru. Liquid Chromatography-tandem Mass Spectrometry, which provides superior specificity and sensitivity was used for the analytical study. For the pharmacokinetic study, the birds were divided into two experimental groups (n=15), Group I and Group II birds were administered with single dose of ciprofloxacin at 8 mg /kg, PO and 5 mg/kg, IV respectively for the pharmacokinetic study. The parameters were determined by non-compartmental analysis using PK solver software. For residue analysis and withdrawal period of ciprofloxacin experimental birds divided into two groups.…

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The present study was done to evaluate the pharmacokinetic parameters of ciprofloxacin following single dose of oral and i.v route of administration and estimating the residual level and withdrawal period. The safety evaluation on liver and kidney following multiple doses of ciprofloxacin orally in dual purpose chicken was done. The study was conducted in thirty day old Indian Rock-3 birds (n=210), a dual purpose chicken strain of White Plymouth Rock developed by Veterinary College, Bengaluru. Liquid Chromatography-tandem Mass Spectrometry, which provides superior specificity and sensitivity was used for the analytical study. For the pharmacokinetic study, the birds were divided into two experimental groups (n=15), Group I and Group II birds were administered with single dose of ciprofloxacin at 8 mg /kg, PO and 5 mg/kg, IV respectively for the pharmacokinetic study. The parameters were determined by non-compartmental analysis using PK solver software. For residue analysis and withdrawal period of ciprofloxacin experimental birds divided into two groups.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 192 pp. Englisch. …

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -El presente estudio se realizó para evaluar los parámetros farmacocinéticos de la ciprofloxacina tras la administración de una dosis única por vía oral e i.v. y estimar el nivel residual y el período de abstinencia. Se evaluó la seguridad hepática y renal tras dosis múltiples de ciprofloxacino por vía oral en pollos de doble propósito. El estudio se llevó a cabo en aves Indian Rock-3 de treinta días de edad (n=210), una cepa de pollo de doble propósito de White Plymouth Rock desarrollada por el Veterinary College, Bengaluru. Para el estudio analítico se utilizó cromatografía líquida-espectrometría de masas en tándem, que proporciona una especificidad y sensibilidad superiores. Para el estudio farmacocinético, las aves se dividieron en dos grupos experimentales (n=15), al Grupo I y al Grupo II se les administró una dosis única de ciprofloxacino a 8 mg /kg, PO y 5 mg/kg, IV respectivamente para el estudio farmacocinético. Los parámetros se determinaron mediante análisis no compartimental utilizando el software PK solver. Para el análisis de residuos y el período de retirada de ciprofloxacino, las aves experimentales se dividieron en dos grupos. El grupo I (n=10) sirvió de control, para la estandarización del equipo. A las aves del Grupo II (n=80) se les administró ciprofloxacino por vía oral. 160 pp. Spanisch.…

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering.

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - El presente estudio se realizó para evaluar los parámetros farmacocinéticos de la ciprofloxacina tras la administración de una dosis única por vía oral e i.v. y estimar el nivel residual y el período de abstinencia. Se evaluó la seguridad hepática y renal tras dosis múltiples de ciprofloxacino por vía oral en pollos de doble propósito. El estudio se llevó a cabo en aves Indian Rock-3 de treinta días de edad (n=210), una cepa de pollo de doble propósito de White Plymouth Rock desarrollada por el Veterinary College, Bengaluru. Para el estudio analítico se utilizó cromatografía líquida-espectrometría de masas en tándem, que proporciona una especificidad y sensibilidad superiores. Para el estudio farmacocinético, las aves se dividieron en dos grupos experimentales (n=15), al Grupo I y al Grupo II se les administró una dosis única de ciprofloxacino a 8 mg /kg, PO y 5 mg/kg, IV respectivamente para el estudio farmacocinético. Los parámetros se determinaron mediante análisis no compartimental utilizando el software PK solver. Para el análisis de residuos y el período de retirada de ciprofloxacino, las aves experimentales se dividieron en dos grupos. El grupo I (n=10) sirvió de control, para la estandarización del equipo. A las aves del Grupo II (n=80) se les administró ciprofloxacino por vía oral.…

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Nastoqschee issledowanie bylo prowedeno dlq ocenki farmakokineticheskih parametrow ciprofloxacina posle odnokratnoj dozy peroral'nogo i wnutriwennogo wwedeniq i ocenki ostatochnogo urownq i perioda wywedeniq. Byla prowedena ocenka bezopasnosti dlq pecheni i pochek posle mnogokratnogo priema ciprofloxacina peroral'no cyplqtam dwojnogo naznacheniq. Issledowanie prowodilos' na tridcatidnewnyh indijskih pticah porody Rok-3 (n=210), shtamme kur dwojnogo naznacheniq porody Belyj plimutrok, wywedennom w Veterinarnom kolledzhe Bengaluru. Dlq analiticheskogo issledowaniq ispol'zowalas' zhidkostnaq hromatografiq-tandemnaq mass-spektrometriq, kotoraq obespechiwaet prewoshodnuü specifichnost' i chuwstwitel'nost'. Dlq farmakokineticheskogo issledowaniq pticy byli razdeleny na dwe äxperimental'nye gruppy (n=15). Pticam I i II grupp wwodili odnokratnuü dozu ciprofloxacina w doze 8 mg/kg, PO i 5 mg/kg, IV sootwetstwenno dlq farmakokineticheskogo issledowaniq. Parametry byli opredeleny putem nekompartmentnogo analiza s ispol'zowaniem programmnogo obespecheniq PK solver. Dlq analiza ostatkow i perioda wywedeniq ciprofloxacina podopytnyh ptic razdelili na dwe gruppy. Gruppa I (n=10) sluzhila kontrolem, dlq standartizacii oborudowaniq. Gruppe II (n=80) ptic peroral'no wwodili ciprofloxacin. …