springer new york apr 2018 (117 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 320 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information. Advanced Imaging Techniques in Clinical Pathology will be of great value to clinical pathologists, biologists, biology researchers, and those working in the clinical and biological laboratory arena.¿Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 180 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This timely volume provides an overview to the causes, effects on systems and clinical approaches of metabolic acidosis. Beginning with a basic understanding of the physiology, pathophysiology and development of this disease, subsequent chapters cover the characteristics and context of the processes that can cause it and a thorough presentation of management strategies. Recommended treatments include those carried out by the health care provider as well as the individual patient, such as dietary management. Clinicians and healthcare professionals will find the tools needed to recognize, work up and manage patients with metabolic acidosis in this practical and concise resource.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 172 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -With numerous methods available for the quantification ofnitric oxide (NO), this detailed book explores their advantages anddisadvantages in order to provide a foundation for further research in plantnitric oxide. After providing a useful practical guide to choosing a techniquefor measuring NO from plant materials, the book continues with chapters on chemiluminescencediaminofluorescence (DAF), EPR spectroscopy, a laser-based method, as well asmany other topics. Written for the highly successful Methods in Molecular Biology series, chapters include introductionsto their respective topics, lists of the necessary materials and reagentsstep-by-step, readily reproducible laboratory methods, and tips on troubleshootingand avoiding known pitfalls.Practical and authoritative, PlantNitric Oxide: Methods and Protocolsserves as a valuable guide to allresearchers working and intending to work in the field of plant nitric oxideresearch.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 216 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This unique book focuses on the non-myeloma plasma cell dyscrasias. A key resource for this group of diseases, the book features the latest in emerging knowledge and therapeutic developments, including novel therapies. Each disease-specific chapter discusses biology, disease course, and appropriate therapeutic interventions, covering plasma cell leukemia, plasmacytoma, POEMS Syndrome and Castleman's Disease, Waldenström macroglobulinemia, immunoglobin deposition disease, and cryoglobulinemic syndromes, among others. The only book dedicated to this intriguing family of diseases, Biology and Management of Unusual Plasma Cell Dyscrasias will be a long-lasting reference for clinicians and scientists alike.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 216 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This text is an introduction to harmonic analysis on symmetric spaces, focusing on advanced topics such as higher rank spaces, positive definite matrix space and generalizations. It is intended for beginning graduate students in mathematics or researchers in physics or engineering. As with the introductory book entitled 'Harmonic Analysis on Symmetric Spaces - Euclidean Space, the Sphere, and the Poincaré Upper Half Plane, the style is informal with an emphasis on motivation, concrete examples, history, and applications. The symmetric spaces considered here are quotients X=G/K, where G is a non-compact real Lie group, such as the general linear group GL(n,P) of all n x n non-singular real matrices, and K=O(n), the maximal compact subgroup of orthogonal matrices. Other examples are Siegel's upper half 'plane' and the quaternionic upper half 'plane'. In the case of the general linear group, one can identify X with the space Pn of n x n positive definite symmetric matrices.Manycorrections and updates have been incorporated in this new edition. Updates include discussions of random matrix theory and quantum chaos, as well as recent research on modular forms and their corresponding L-functions in higher rank. Many applications have been added, such as the solution of the heat equation on Pn, the central limit theorem of Donald St. P. Richards for Pn, results on densest lattice packing of spheres in Euclidean space, and GL(n)-analogs of the Weyl law for eigenvalues of the Laplacian in plane domains.Topics featured throughout the text include inversion formulas for Fourier transforms, central limit theorems, fundamental domains in X for discrete groups ¿ (such as the modular group GL(n,Z) of n x n matrices with integer entries and determinant ±1), connections with the problem of finding densest lattice packings of spheres in Euclidean space, automorphic forms, Hecke operators, L-functions, and the Selberg trace formula and its applications in spectral theory as well as number theory.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 504 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This textbook introduces and explains the basic concepts on which statics is based utilizing real engineering examples. The authors emphasize the learning process by showing a real problem, analyzing it, simplifying it, and developing a way to solve it. This feature teaches students intuitive thinking in solving real engineering problems using the fundamentals of Newton¿s laws.This book also: Stresses representation of physical reality in ways that allow students to solve problems and obtain meaningful results Emphasizes identification of important features of the structure that should be included in a model and which features may be omitted Facilitates students' understanding and mastery of the 'flow of thinking' practiced by professional engineersSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 584 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book provides a comprehensive introduction to the latest advances in the mathematical theory and computational tools for modeling high-dimensional data drawn from one or multiple low-dimensional subspaces (or manifolds) and potentially corrupted by noise, gross errors, or outliers. This challenging task requires the development of new algebraic, geometric, statistical, and computational methods for efficient and robust estimation and segmentation of one or multiple subspaces. The book also presents interesting real-world applications of these new methods in image processing, image and video segmentation, face recognition and clustering, and hybrid system identification etc.This book is intended to serve as a textbook for graduate students and beginning researchers in data science, machine learning, computer vision, image and signal processing, and systems theory. It contains ample illustrations, examples, and exercises and is made largely self-contained with three Appendices which survey basic concepts and principles from statistics, optimization, and algebraic-geometry used in this book.René Vidal is a Professor of Biomedical Engineering and Director of the Vision Dynamics and Learning Lab at The Johns Hopkins University. Yi Ma is Executive Dean and Professor at the School of Information Science and Technology at ShanghaiTech University. S. Shankar Sastry is Dean of the College of Engineering, Professor of Electrical Engineering and Computer Science and Professor of Bioengineering at the University of California, Berkeley.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 600 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The oceans represent a vast, complex and poorly understood ecosystem. Marine Ecological Processes is a modern review and synthesis of marine ecology that provides the reader with a lucid introduction to the intellectual concepts, approaches, and methods of this evolving discipline. Comprehensive in its coverage, this book focuses on the processes controlling marine ecosystems, communities, and populations and demonstrates how general ecological principles--derived from terrestrial and freshwater systems as well--apply to marine ecosystems.Global warming and increased eutrophication and wetland destruction in recent years has made the study of ecological processes even more important for the preservation of marine environments. This thoroughly updated and expanded edition will provide students of marine ecology, marine biology, and oceanography with numerous illustrations, examples, and references which clearly impart to the reader the current state of research in thisfield: its achievements as well as unresolved controversies.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 724 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This text provides a comprehensive, state-of-the-art review of catheter based approaches to valve and aortic diseases. The scope encompasses involve all the current and upcoming transcatheter aortic valve technologies as well as mitral, pulmonary and tricuspid valve technologies. Aortic diseases including transcatheter repair of descending aneurysms are included and the upcoming technologies designed to repair aortic dissections, traumatic injury, and ascending arch stent repair are highlighted.Catheter Based Valve and Aortic Surgery will be a useful tool for cardiac and vascular surgeons, interventional cardiologists, general cardiologists, and clinicians and researchers with an interest in these exciting new developments in structural heart and vascular diseases.¿Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 364 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This detailed volume provides diagnosticians and researchers with practical methodologies and approaches to tackle animal coronaviruses. It explores conventional immunohistochemistry, virus neutralization, enzyme-linked immunosorbent assays, expression and purification of recombinant viral proteins, and various molecular assays, including conventional and real-time reverse transcription-PCR, reverse genetics methodology, and next generation sequencing and sequence analyses. As part of the Springer Protocols Handbooks series, chapters contain readily reproducible laboratory protocols as well as expert tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Animal Coronaviruses serves as an ideal reference for researchers examining a wide variety of coronavirus species in the Coronaviridae.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 228 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This contributed volume is the result of a July 2010 workshop at the University of Wuppertal Interdisciplinary Centre for Science and Technology Studies which brought together world-wide experts from physics, philosophy and history, in order to address a set of questions first posed in the 1950s: How do we compare spacetime theories How do we judge, objectively, which is the ¿best¿ theory Is there even a unique answer to this question The goal of the workshop, and of this book, is to contribute to the development of a meta-theory of spacetime theories. Such a meta-theory would reveal insights about specific spacetime theories by distilling their essential similarities and differences, deliver a framework for a class of theories that could be helpful as a blueprint to build other meta-theories, and provide a higher level viewpoint for judging which theory most accurately describes nature. But rather than drawing a map in broad strokes, the focus is on particularly rich regions in the ¿space of spacetime theories.¿This work will be of interest to physicists, as well as philosophers and historians of science working with or interested in General Relativity and/or Space, Time and Gravitation more generally.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 344 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book focuses on recently developed High Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques. Divided into three sections, in vitro assays, in vivo assays, and computational techniques to analyze HTS data are all examined. Written for the highly successful Methods in Molecular Biology series, most chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 188 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume explores the still undiscovered secrets of tumor immunology and cancer immunology by discussing the methods and techniques that world-renowned experts in the field use in their laboratories. This book provides a better understanding of the rules governing tumor and cancer immunology, and discusses innovations in the technology of the immunological ¿smart bullets¿ (monoclonal antibodies, vaccines, tumor-reactive T cells) used to specifically target cancer cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and cutting-edge, Tumor Immunology: Methods and Protocols contains a wide breadth of subject coverage that any scientist, clinician, or industry professional interested in this field will find valuable.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 180 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume explores the different approaches and techniques used by researchers to study the recent challenges and developments in metabolic profiling. This book is divided into IV parts. Part I contains chapters that highlight basic concepts, such as experimental design, data treatment, metabolite identification, and harmonization. Part II describes experimental protocols for both targeted and untargeted metabolomics covering the basic analytical technologies: LC-MS, GC-MS, NMR and CE-MS. In addition the protocols describe methods for the study of tissues, feces, blood and other types of biological samples as well as the application of chemical derivatization for GC-MS. Parts III and IV present the use of metabolomics in the study of food, plants and the life sciences, with examples from the quest for the discovery of disease biomarkers, physical exercise omics and metabolic profiling of food, fruit and wine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 304 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume explores the intersection of robust intelligence (RI) and trust in autonomous systems across multiple contexts among autonomous hybrid systems, where hybrids are arbitrary combinations of humans, machines and robots. To better understand the relationships between artificial intelligence (AI) and RI in a way that promotes trust between autonomous systems and human users, this book explores the underlying theory, mathematics, computational models, and field applications. It uniquely unifies the fields of RI and trust and frames it in a broader context, namely the effective integration of human-autonomous systems.A description of the current state of the art in RI and trust introduces the research work in this area. With this foundation, the chapters further elaborate on key research areas and gaps that are at the heart of effective human-systems integration, including workload management, human computer interfaces, team integration and performance, advanced analytics, behavior modeling, training, and, lastly, test and evaluation.Written by international leading researchers from across the field of autonomous systems research, Robust Intelligence and Trust in Autonomous Systems dedicates itself to thoroughly examining the challenges and trends of systems that exhibit RI, the fundamental implications of RI in developing trusted relationships with present and future autonomous systems, and the effective human systems integration that must result for trust to be sustained.Contributing authors: David W. Aha, Jenny Burke, Joseph Coyne, M.L. Cummings, Munjal Desai, Michael Drinkwater, Jill L. Drury, Michael W. Floyd, Fei Gao, Vladimir Gontar, Ayanna M. Howard, Mo Jamshidi, W.F. Lawless, Kapil Madathil, Ranjeev Mittu, Arezou Moussavi, Gari Palmer, Paul Robinette, Behzad Sadrfaridpour, Hamed Saeidi, Kristin E. Schaefer, Anne Selwyn, Ciara Sibley, Donald A. Sofge, Erin Solovey, Aaron Steinfeld, Barney Tannahill, Gavin Taylor, Alan R. Wagner, Yue Wang, Holly A. Yanco, Dan Zwillinger.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 284 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book explores the impact of climate change on agriculture and our future ability to produce the crops which are the foundation of the human diet. Specifically, individual chapters explore the potential for genomics assisted breeding of improved crops with greater yield and tolerance to the stresses associated with predicted climate change scenarios. Given the clear and unmet challenge to mitigate climate changing events, this book will be of wide interest from plant breeders and environmental scientists, government bodies through to a more general audience who are interested in the likely impact of climate change on agriculture.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 212 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The volume aims at providing an overview of cutting-edge methods and protocols used in neuroscience and neurological research. Neurotransmitter Transporters: Investigative Methods will be of interest to scientists, graduate students, and advanced undergraduates who seek an overview of methods and protocols in this field of neuroscience. It will also be of interest to physicians who are carrying out imaging and postmortem studies of neurotransmitter transporters in the human brain. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical, Neurotransmitter Transporters: Investigative Methods aims to ensure successful results in thefurther study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 244 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This detailed volume provides a single, valuable reference source formethods that definitively identify and accurately quantify apoptosis. The book begins with common methods utilized to detect and quantitate apoptosis, as well as apoptosis signaling pathways in toxicological and other related research. It continues with multi-parametric and phased apoptosis assays for detecting early and late apoptosis or distinguishing apoptosis from necrosis and autophagy. Subsequent chapters focus on recent advances in real time and high-throughput assays that detect and quantitate apoptosis and apoptosis signaling pathways. Final chapters focus on recent developments in preclinical anticancer therapeutics targeting apoptosis. Written for the Methods in Pharmacology and Toxicology series, chapters feature step-by-step descriptions of the methodologies, as well as expert tips and implementation advice. Vital and authoritative, Apoptosis Methods in Toxicology serves novice scientists as well as experts, utilizing a range of instruments from common laboratory equipment to high-end expensive and automated machinery capable of performing real time apoptotic measurements.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 256 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume details the importance of multiple experimental techniques and computational methods needed to obtain the comprehensive picture of protein complex structure, dynamics and assembly afforded by the emerging field of integrative structural biology. Chapters guide readers through the broad spectrum of approaches required for a complete representation of protein complexes, including expression and purification, experimental characterization of structure and assembly, and computational methods for identifying protein complexes and modelling their assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Protein Complex Assembly: Methods and Protocols aims to ensure successful results in the further study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 524 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume explores the applications of reporter gene technology and the methodologies needed for their effective implementation. The chapters in this book cover practical topics such as how to integrate reporter constructs into cellular models, viral delivery, splicing applications, in vivo imaging, and a guide to the use of multi-cistronic constructs. Additionally, chapters also include detailed mechanistic uses of reporter genes in cellular pathways, and a look at project and data management of screening applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 248 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume provides resources, ideas, and bench manuals for the study of breast cancer. This book is divided into five sections: methods used in clinical laboratory for diagnosis (Detection of Molecular Markers of Breast Cancer); methods used in both clinical and research laboratories for testing genetic alterations (Genetic Detection of Breast Cancer) and (Isolation of Breast Cancer Cells); methods used to study the behavior of breast cancer cells (In Vitro Experimental Assays for Breast Cancer); and methods used for mimicking human breast cancer in a living organism (In Vivo Experimental Models for Breast Cancer). Breast Cancer: Methods and Protocols also explores several recently developed techniques for the study of breast cancer progression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and thorough, Breast Cancer: Methods and Protocols, is a valuable handbook for both graduate and advanced undergraduate students of biological sciences, as well as scientists, technicians, and physicians working in the academic, hospital, or pharmaceutical industry aimed at studying or diagnosing breast cancer.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 344 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume explores various methodologies to study biochemical, molecular, and cellular biology aspects of some processes regulated by protein SUMOylation. SUMO: Methods and Protocols is organized into four parts, and starts with an historical overview on protein SUMOylation and a presentation of the methods included in the book. The first part also includes a review on chromatin regulation by dynamic SUMO modifications. The second part focuses on in vitro techniques, including biochemical methods to study mechanistic aspects of protein SUMOylation. The third part includes protocols to be used with cell cultures, which often are the first approaches used in most laboratories. The final part includes methodologies adapted for the analysis in vivo using distinct model organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include a brief introduction to the subject, a list of necessary materials and reagents, a step-by-step reproducible laboratory protocol ending with a Notes section on troubleshooting tips, and tips and strategies to avoid known pitfalls. Unique and cutting-edge, SUMO: Methods and Protocols provides a comprehensive source of protocols for specialists and researchers not familiar with this vital system.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 320 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume provides acollection of protocols and approaches for the creation of novel ligand bindingproteins, compiled and described by many of today's leaders in the field ofprotein engineering. Chapters focus on modeling protein ligand bindingsites, accurate modeling of protein-ligand conformational sampling, scoring ofindividual docked solutions, structure-based design program such as ROSETTAprotein engineering, and additional methodological approaches. Examples of applicationsinclude the design of metal-binding proteins and light-induced ligand bindingproteins, the creation of binding proteins that also display catalyticactivity, and the binding of larger peptide, protein, DNA and RNAligands. Written in the highly successful Methods in MolecularBiology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-stepreadily reproducible laboratory protocols, and tips ontroubleshooting and avoidingknown pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 392 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume containsprotocols specifically designed for studying programmed cell death, and alsodiscusses recent advances in techniques that span broader areas of biology thathave been recently used or that have potential to be incorporated into cell deathresearch. The protocols are mostly described in the context of mammaliansystems, but also cover other systems such as plants, Drosophila, andyeast. Programmed Cell Death: Methods and Protocols is comprised of 20chapters: Chapters 1-5 describe apoptosis detection techniques; Chapter 6-9describe methods for studying apoptosis associated with various pathologies indifferent organs including the lymphoid compartment, intestinal epitheliumgranulocytes, and cardiomyocytes; Chapter 11-13 cover protocols and techniquesfor studying apoptosis in non-mammalian systems; Chapters 14-16 coverbiochemical and biophysical methods for studying Bcl-2 family protein dynamicsand protein-protein interactions during apoptosis;and the last four chaptersexplore protocols that are useful not only in apoptosis research but in widerareas of biological research, such as genome editing, inducible transgenes, andproteomics. Written in the highly successful Methods in Molecular Biologyaeries format, chapters include introductions to their respective topics, listsof the necessary material and reagents, step-by-step, readily reproduciblelaboratory protocol, and tips on troubleshooting and avoiding known pitfalls.Thoroughand cutting-edge, Programmed Cell Death: Methods and Protocols is acomprehensive and valuable resource for researchers, ranging from beginner toexpert, in their studies on programmed cell death.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 304 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This second edition volume expands on the previous edition by presenting updated protocols for several of the techniques described in the first edition of Drosophila: Methods and Protocols and current methods that cover recent breakthroughs in Drosophila research. The book begins with a description of FlyBase--a database of genes and genomes--followed by the presentation of systems for versatile gene expression in the fly. The first few chapters in this book detail gene knockdown and editing, including CRISPR-Cas9 and protein knockdown. The next few chapters are devoted to methods describing live imaging of different tissues and organs, followed by chapters on how to quantify image data and how to probe tissue mechanics by laser ablation. The next two chapters provide methods for analyzing transcription followed by protocols to study growth, metabolism, ageing, and behavior in Drosophila. This volume concludes with chapters on electrophysiological recordings and methods to establish cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Drosophila: Methods and Protocols, Second Edition is a valuable source of hands-on protocols and reviews for molecular, cell, and developmental biologists using Drosophila as model systems in their work.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 372 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume details several important databases and data mining tools. Data Mining Techniques for the Life Sciences, Second Edition guides readers through archives of macromolecular three-dimensional structures, databases of protein-protein interactions, thermodynamics information on protein and mutant stability, ¿Kbdock¿ protein domain structure database, PDB_REDO databank, erroneous sequences, substitution matrices, tools to align RNA sequences, interesting procedures for kinase family/subfamily classifications, new tools to predict protein crystallizability, metabolomics data, drug-target interaction predictions, and a recipe for protein-sequence-based function prediction and its implementation in the latest version of the ANNOTATOR software suite. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Data Mining Techniques for the Life Sciences, Second Edition aims to ensure successful results in the further study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 568 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume assembles protocols for chromosome engineering and genome editing in two recently developed approaches for manipulating chromosomal and genomic DNA in plants. The first approach is a ¿plant chromosome vector¿ system, which allows the introduction of desired genes or DNA into target sites on the chromosome vector, particularly by sequence-specific recombination. The second approach is ¿genome-editing,¿ which makes it possible to introduce mutations into any of the genes of DNA that we wish to change. In addition, this book also covers other related techniques used to accelerate progress in plant chromosome and genome engineering. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Chromosome and Genomic Engineering in Plants: Methods and Protocols provides a comprehensive source of protocols and other necessary information to anyone interested in this field of study.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 232 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume expands on statistical analysis of genomic data by discussing cross-cutting groundwork material, public data repositories, common applications, and representative tools for operating on genomic data. Statistical Genomics: Methods and Protocols is divided into four sections. The first section discusses overview material and resources that can be applied across topics mentioned throughout the book. The second section covers prominent public repositories for genomic data. The third section presents several different biological applications of statistical genomics, and the fourth section highlights software tools that can be used to facilitate ad-hoc analysis and data integration. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible analysis protocols, and tips on troubleshooting and avoiding known pitfalls.Through and practical, Statistical Genomics: Methods and Protocols, explores a range of both applications and tools and is ideal for anyone interested in the statistical analysis of genomic data.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 432 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This practical volume examines a number of topicsthat explore the current status of immunotherapy and diagnostic markers forneurodegenerative disorders. With a focus on Alzheimer¿s disease, the firstsections of the book examine immunotherapeutic approaches for theaforementioned disease as well as for Parkinson¿s disease and Huntington¿s diseaseamongst others. The last section of the book covers the importance of biomarkertechniques to catch these diseases early enough for the treatments to be mostuseful. Written for the Methods inPharmacology and Toxicology series, this book contains the kind of detaileddescriptions and implementation advice that will offer a smooth transition intothe lab.Authoritative and useful, Immunotherapy and Biomarkers inNeurodegenerative Disorders aims to aid in the continued progress in thedevelopment of novel immune-based drugs and diagnostic tools for thesedevastating brain diseases.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 300 pp. Englisch.