Springer us jan 2005 (40 Ergebnisse)

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume addresses advanced DEA methodology and techniques developed for modeling unique new performance evaluation issues. Many numerical examples, real management cases and verbal descriptions make it very valuable for researchers and practitioners. 428 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is about public education reform and the future of pubHc education funding. Given the many articles, books, and conferences that have focused on the issue of public education reform, it is reasonable to ask whether the world needs still another volume on this subject. In my defense, I would argue that, although there is a large literature on public education reform, there is precious little that tries to sketch the big picture. Too often, both in research and in practice, it is easy to lose sight of the forest, for all the focus on the individual trees. While such detailed analysis is of critical value, that value derives both from its specificity and from its ability to fit into a larger, coherent whole. Unfortunately, our understanding of the public education process is still incomplete and disconnected, particularly with regard to the connections between research, policy, and practice. This book is an attempt to step back for a moment to get one's bearings before jumping headlong back into the forest. It is my hope that this book will be of value to a wide variety of reader- researchers in departments of economics and schools of education, policy makers at all levels, and, of course, the practitioners slogging away in the trenches. 238 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Technology Enhanced Learning is an essential reference for both academic and professional researchers in the field of institutional and home education.Technology Enhanced Learning (TeL) has provided tools and infrastructure to education and training disciplines for over a decade. The papers presented in this volume cover research issues including pedagogical and evaluation theories, integrated learning environments, e-learning experiments, trials and overall results from actual TeL deployment.This state-of-the-art volume contains a compilation of select papers presented during the Technology Enhanced Learning (TeL) workshop co-located with the World Computer Congress, August 2004, in Toulouse, France. 204 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Modeling Performance Measurement: Applications and Implementation Issues in DEA presents unified results from several authors¿ recent DEA research. These new DEA methodology and techniques are developed in application-driven scenarios that go beyond the identification of the best-practice frontier and seek solutions to aid managerial decisions. These new DEA developments are well-grounded in real world applications. Both DEA researchers and practitioners will find this book helpful. Theory is provided for DEA researchers for further development and possible extensions. However, it should also be mentioned that each theory is presented in practical terms with numerical examples, simple real management cases and verbal descriptions. These concrete examples will be of value to researchers, students, and practitioners.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 428 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book is about public education reform and the future of pubHc education funding. Given the many articles, books, and conferences that have focused on the issue of public education reform, it is reasonable to ask whether the world needs still another volume on this subject. In my defense, I would argue that, although there is a large literature on public education reform, there is precious little that tries to sketch the big picture. Too often, both in research and in practice, it is easy to lose sight of the forest, for all the focus on the individual trees. While such detailed analysis is of critical value, that value derives both from its specificity and from its ability to fit into a larger, coherent whole. Unfortunately, our understanding of the public education process is still incomplete and disconnected, particularly with regard to the connections between research, policy, and practice. This book is an attempt to step back for a moment to get one's bearings before jumping headlong back into the forest. It is my hope that this book will be of value to a wide variety of reader- researchers in departments of economics and schools of education, policy makers at all levels, and, of course, the practitioners slogging away in the trenches.Libri GmbH, Europaallee 1, 36244 Bad Hersfeld 238 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -One of the major controversies in macroeconomics over the last 30 years has been that on the effectiveness of stabilization policies. However, this debate, between those who believe that this kind of policies is useless if not harmful and those who argue in favor of it, has been mainly theoretical so far.The Rational Expectation Hypothesis, Time-Varying Parameters and Adaptive Control wants to represent a step toward the construction of a common ground on which to empirically compare the two 'beliefs' and to do this three strands of literature are brought together. The first strand is the research on time-varying parameters (TVP), the second strand is the work on adaptive control and the third one is the literature on linear stationary models with rational expectations (RE). The material presented in The Rational Expectation Hypothesis, Time-Varying Parameters and Adaptive Control is divided into two parts. Part 1 combines the strand of literature on adaptive control with that on TVP. It generalizes the approach pioneered by Tse and Bar-Shalom (1973) and Kendrick (1981) and one recently used in Amman and Kendrick (2002), where the law of motion of the TVP and the hyperstructural parameters are assumed known, to the case where the hyperstructural parameters are assumed unknown. Part 2 is devoted to the linear single-equation stationary RE model estimated with the error-in-variables (EV) method. It presents a new formulation of this problem based on the use of TVP in an EV model. This new formulation opens the door to a very promising development. All the theory developed in the first part to control a model with TVP can sic et simpliciter be applied to control a model with RE. 280 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Computing in the Nordic countries started in late 1940s mainly as an engineering activity to build computing devices to perform mathematical calculations and assist mathematicians and engineers in scientific problem solving. The early computers of the Nordic countries emerged during the 1950s and had names like BARK, BESK, DASK, SMIL, SARA, ESKO, and NUSSE. Each of them became a nucleus in institutes and centres for mathematical computations programmed and used by highly qualified professionals. However, one should not forget the punched-card machine technology at this time that had existed for several decades. In addition, we have a Nordic name, namely Frederik Rosing Bull, contributing to the fundaments of punched card technology and forming the French company Bull. Commercial products such as FACIT EDB and SAAB D20-series computers in Sweden, the Danish GIER computer, the Nokia MIKKO computer in Finland, as well as the computers of Norsk Data in Norway followed the early computers. In many cases, however, companies and institutions did not further develop or exploit Nordic computing hardware, even though it exhibited technical advantages. Consequently, in the 1970s, US computers, primarily from IBM, flooded the Nordic market. 512 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Broadband Satellite Communication Systems and the Challenges of Mobility is an essential reference for both academic and professional researchers in the field of telecommunications, computer networking and wireless networks.Recently the request of multimedia services has been rapidly increasing and satellite networks appear to be attractive for a fast service deployment and for extending the typical service area of terrestrial systems. In comparison with traditional wide area networks, a characteristic of satellite communication systems is their ability in broadcasting and multicasting multimedia information flows anywhere over the satellite coverage. The papers presented in this volume highlight key areas such as Satellite Network Architectures, Services and Applications; Mobile Satellite Systems and Services;and Hybrid Satellite and Terrestrial Networks.Mobility will inevitably be one of the main characteristics of future networks, terminals and applications and, thus, extending and integrating fixed network protocols and services to mobile systems represents one of the main issues of present networking. The secondary focus of this volume is on challenges of mobility, that is, on technologies, protocols and services for the support of seamless and nomadic user access to new classes of applications in person-to-person, device-to-device and device-to-person environments. The book comprises recent results of research and development in the following areas; Seamless mobility; Mobile ad hoc and sensor networks;Analysis, simulation and measurements of mobile and wireless systems; Integration and inter-working of wired and wireless networks;QoS in mobile and wireless networks;Future trends and issues concerning mobility.Thisstate-of-the-art volumecontains a collection of papers from two of the workshops of the 18th IFIP World Computer Congress, held August 22-27, 2004, in Toulouse, France: the Workshop on Broadband Satellite Communication Systems, and the Workshop on the Challenges of Mobility. 270 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is a compilation of articles based on some of the talks given at the Centro de Estudios Cientificos (CECS) in Valdivia during the course of a celebration to th mark the 60 birthdays of Ramon Latorre and Enrico Stefani. Ramon Latorre is one of the most outstanding figures in channel Biophysics today. The first surprise is that he trained as a Biochemist! He soon, however, became a biophysicist through his work with Guayo (Eduardo) Rojas who guided him during his Ph. D thesis in the Laboratorio de Fisiologia Celular in Montemar. His work at N. I. H with Gerald Eherenstein and Harold Lecar constitutes one of the milestones of single ion channel Biophysics. This classical work, done in planar bilayers, set the basis for understanding voltage-dependent conductances with single channel studies and predates, by many years, later studies using patch clamping techniques. Ramon was one of the firsts to find and recognize the importance of calci- activated potassium channels and to begin a detailed study of channel properties. He pioneered the ideas of voltage and calcium modulation of the open probability and he added detailed studies of gating and its modulation by other ions. Ramon is also interested in permeation and selectivity and he produced classical studies on the number of water molecules in the channel and sites occupied by barium. Results and concepts that have recently taken front page as the structure of KcSa has been described. 188 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As people move through life, they continually shift affiliation from one position to another, dependent on the wider contexts of their interactions. Different forms of material culture may be employed as affiliations shift, and the connotations of any given set of artifacts may change. In this volume the authors explore these overlapping spheres of social affiliation. Social actors belong to multiple identity groups at any moment in their life. It is possible to deploy one or many potential labels in describing the identities of such an actor. Two main axes exist upon which we can plot experiences of social belonging - the synchronic and the diachronic. Identities can be understood as multiple during one moment (or the extended moment of brief interaction), over the span of a lifetime, or over a specific historical trajectory.From the IntroductionThe international contributions each illuminate how the various identifiers of race, ethnicity, sexuality, age, class, gender, personhood, health, and/or religion are part of both material expressions of social affiliations, and transient experiences of identity. The Archaeology of Plural and Changing Identities: Beyond Identification will be of great interest to archaeologists, anthropologists, historians, curators and other social scientists interested in the mutability of identification through material remains. 288 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Field emission is a phenomenon described by quantum mechanics. Its emission capability is millions times higher than that of any other known types of electron emission. Nowadays this phenomenon is experiencing a new life due to wonderful applications in the atomic resolution microscopy, in electronic holography, and in the vacuum micro- and nanoelectronics in general. The main field emission properties, and some most remarkable experimental facts and applications, are described in this book. 224 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -For over a decade, there has been an increasing interest in the use of supply chain methods to improve performance across the entire business enterprise. Numerous industries have recognized the importance of efficient supply chain integration, and, as a result, supply chain management has become a standard part of business practice. The Practice of Supply Chain Management: Where Theory and Application Converge is a must-have volume for users of supply chain management methods, supply chain management researchers, and students in supply chain management. The objective ofthe bookis to provide an overview of this important practice-research cycle, and it is organized into three sections: Core Concepts and Practices; Emerging Supply Chain Practices; and Supply Chain in Action. The focus of the book is on supply chain practice, but supply chain practice that has been heavily influenced by supply chain research. It is this synergy between research and practice that continues to simulate new directions for research. 372 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -One of the major controversies in macroeconomics over the last 30 years has been that on the effectiveness of stabilization policies. However, this debate, between those who believe that this kind of policies is useless if not harmful and those who argue in favor of it, has been mainly theoretical so far.The Rational Expectation Hypothesis, Time-Varying Parameters and Adaptive Control wants to represent a step toward the construction of a common ground on which to empirically compare the two 'beliefs' and to do this three strands of literature are brought together. The first strand is the research on time-varying parameters (TVP), the second strand is the work on adaptive control and the third one is the literature on linear stationary models with rational expectations (RE).The material presented in The Rational Expectation Hypothesis, Time-Varying Parameters and Adaptive Control is divided into two parts. Part 1 combines the strand of literature on adaptive control with that on TVP. It generalizes the approach pioneered by Tse and Bar-Shalom (1973) and Kendrick (1981) and one recently used in Amman and Kendrick (2002), where the law of motion of the TVP and the hyperstructural parameters are assumed known, to the case where the hyperstructural parameters are assumed unknown. Part 2 is devoted to the linear single-equation stationary RE model estimated with the error-in-variables (EV) method. It presents a new formulation of this problem based on the use of TVP in an EV model. This new formulation opens the door to a very promising development. All the theory developed in the first part to control a model with TVP can sic et simpliciter be applied to control a model with RE.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 280 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book is a compilation of articles based on some of the talks given at the Centro de Estudios Cientificos (CECS) in Valdivia during the course of a celebration to th mark the 60 birthdays of Ramon Latorre and Enrico Stefani. Ramon Latorre is one of the most outstanding figures in channel Biophysics today. The first surprise is that he trained as a Biochemist! He soon, however, became a biophysicist through his work with Guayo (Eduardo) Rojas who guided him during his Ph. D thesis in the Laboratorio de Fisiologia Celular in Montemar. His work at N. I. H with Gerald Eherenstein and Harold Lecar constitutes one of the milestones of single ion channel Biophysics. This classical work, done in planar bilayers, set the basis for understanding voltage-dependent conductances with single channel studies and predates, by many years, later studies using patch clamping techniques. Ramon was one of the firsts to find and recognize the importance of calci- activated potassium channels and to begin a detailed study of channel properties. He pioneered the ideas of voltage and calcium modulation of the open probability and he added detailed studies of gating and its modulation by other ions. Ramon is also interested in permeation and selectivity and he produced classical studies on the number of water molecules in the channel and sites occupied by barium. Results and concepts that have recently taken front page as the structure of KcSa has been described.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 188 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Introduces the theory of multi-port signals and systems with a focus on vector-valued signal transmissionProvides an introduction to the fundamentals, implementation and applications of MIMO techniquesAn excellent guide for advanced students, practicing engineers and researchers working on multi-port electrical circuits, RF networks and wireless communications 206 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is a collection of my essays on Gustav von Schmoller (1838- 1917), Max Weber (1864-1920), and Joseph Alois Schumpeter (1883-1950), published during the past fifteen years. These three intellectual giants are connected with the German Historical School of Economics in different ways. In the history of economics, the German Historical School has been described as a heterodox group of economic researchers who flourished in the Germ- speaking world throughout the nineteenth century. The definition of a 'school' is always problematic. Even if the core of a certain idea were identified in the continuous and discontinuous process of the filiation and ramification of thought, it is still possible to trace its predecessors, successors, and sympathizers in different directions, creating an amorphous entity of a school. It is beyond question, however, that Schmoller was the leader of the younger German Historical School, the genuine school with a sociological 1 reality. Schmoller was indeed the towering figure of the Historical School at its zenith. 224 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is an authored book based upon a survey of a large number of companies, on the role of organization learning and innovation strategy in successful new product development. The audience for these insights is any practitioner working with corporations in new product development, as well as advanced undergrad and graduate students taking courses in new product development of management science in schools of business and engineering. 212 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a comprehensive analysis of implications of DNA methylation on cancer diagnosis and cancer therapy. This unique volume focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy. Key features of this book include discussions of the following topics:The molecular machinery responsible for DNA methylation and their impact on gene expression and tumorigenesis.The emerging relation between DNA methylation and chromatin modifying proteins.How the relationship between DNA methylation and chromatin modifying proteins might clarify the mechanisms and therapeutic implications of aberrant DNA methylation in cancer.Illustrations of the diagnostic potential of methylation in cancer and novel tools for using methylation profiling of cancers.The therapeutic potential of the DNA methylation machinery and novel attempts to target the DNA methylation enzymes in anticancer therapy.This book will be of interest to a wide audience, including oncologists, researchers and clinicians, and graduate students in the fields of oncology, molecular biology, and cancer therapy, as well as researchers and decision-makers in industry focusing on anticancer drugs and diagnosis. 260 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. ^ Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ ing it as a ^^MddchenfUr alles,' (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, 'The Function of Toll-Like Receptors', Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in 'Structures and Motifs Involved in Toll Signaling'. 232 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Emergent Computation emphasizes the interrelationship of the different classes of languages studied in mathematical linguistics (regular, context-free, context-sensitive, and type 0) with aspects to the biochemistry of DNA, RNA, and proteins. In addition, aspects of sequential machines such as parity checking and semi-groups are extended to the study of the Biochemistry of DNA, RNA, and proteins. Mention is also made of the relationship of algebraic topology, knot theory, complex fields, quaternions, and universal turing machines and the biochemistry of DNA, RNA, and proteins.Emergent Computation tries to avoid an emphasis upon mathematical abstraction ('elegance') at the expense of ignoring scientific facts known to Biochemists. Emergent Computation is based entirely upon papers published by scientists in well-known and respected professional journals. These papers are based upon current research. A few examples of what is not ignored to gain 'elegance':- DNA exists as triple and quadruple strands - Watson-Crick complementary bases have mismatches - There can be more than four bases in DNA - There are more than sixty-four codons - There may be more that twenty amino acids in proteins While Emergent Computation emphasizes bioinformatics applications, the last chapter studies mathematical linguistics applied to areas such as languages found in birds, insects, medical applications, anthropology, etc.Emergent Computation tries to avoid unnecessary mathematical abstraction while still being rigorous. The demands made upon the knowledge of chemistry or mathematics is minimized as well. The collected technical references are valuable in itself for additional reading. 440 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Following the pattern of the Internet growth in popularity, started in the early 1990s, the current unprecedented expansion of wireless technology promises to have an even greater effect on how people communicate and interact, with considerable socio-economic impact all over the world. The driving force behind this growth is the remarkable progress in component miniaturization, integration, and also devel- ments in waveforms, coding, and communication protocols. Besides established infrastructurebased wireless networks (cellular, WLAN, sat- lite) ad-hoc wireless networks emerge as a new platform for distributed applications and for personal communication in scenarios where deploying infrastructure is not feasible. In ad-hoc wireless networks, each node is capable of forwarding packets on behalf of other nodes, so that multi-hop paths provide end-to-end connectivity. The increased flexibility and mobility of ad-hoc wireless networks are favored for appli- tions in law enforcement, homeland defense and military. In a world where wireless networks become increasingly interoperable with each other and with the high-speed wired Internet, personal communication systems will transform into universal terminals with instant access to variate content and able of handle demanding tasks, such as multimedia and real-time video. With users roaming between networks, and with wide variation in wireless link quality even in a single domain, the communications terminal must continue to provide a level of Quality of Service that is acceptable to the user and conforms to a contracted Service Level Agreement. 724 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Topics that are covered include electron scattering in the scanning TEM; basic theory of inelastic electron imaging; study of confined atoms by electron excitation; helium bubbles created in extreme pressure with application to nuclear safety; lithium ion implantation; electron and positron scattering from clusters; electron scattering from physi- and chemi-absorbed molecules on surfaces; coincidence studies; electron scattering from biological molecules; electron spectroscopy as a tool for environmental science; electron scattering in the presence of intense fields; electron scattering from astrophysical molecules; electon interatctions an detection of x-ray radiation. 356 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Zinc Finger Proteins is the first book to systematically assemble knowledge of various zinc finger proteins belonging to several families and to describe features of zinc finger proteins at levels ranging from atomic to cellular and to organismal. Significance of zinc itself is also addressed as are important domains often associated with zinc fingers. This book is an ideal resource for students who want to learn about zinc finger proteins as well as for scientists who work on gene expression, signal transduction, differentiation, development, cancer and neurological diseases. 296 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume is a collection of my essays on Gustav von Schmoller (1838¿ 1917), Max Weber (1864¿1920), and Joseph Alois Schumpeter (1883¿1950), published during the past fifteen years. These three intellectual giants are connected with the German Historical School of Economics in different ways. In the history of economics, the German Historical School has been described as a heterodox group of economic researchers who flourished in the Germ- speaking world throughout the nineteenth century. The definition of a ¿school¿ is always problematic. Even if the core of a certain idea were identified in the continuous and discontinuous process of the filiation and ramification of thought, it is still possible to trace its predecessors, successors, and sympathizers in different directions, creating an amorphous entity of a school. It is beyond question, however, that Schmoller was the leader of the younger German Historical School, the genuine school with a sociological 1 reality. Schmoller was indeed the towering figure of the Historical School at its zenith.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 224 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. ^ Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ ing it as a ^^MddchenfUr alles,' (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, 'The Function of Toll-Like Receptors', Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in 'Structures and Motifs Involved in Toll Signaling'.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 232 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information It was tempting to speculate that DNA me thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 260 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain 'zinc finger. ' Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term 'zinc finger' differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The challenge of managing a business enterprise today is to ensure that it can remain efficient and competitive in a dynamic marketplace characterized by high competition, unstable demands, heterogeneous market segments, and short product life cycles. Increasing the pace of new product introduction enables dealing with shorter product lives. To sustain competitiveness, a firm has to be innovative as well as quick to respond to the changing customer needs in order to provide better and faster products to market than competitors. New product development (NPD) is considered as a process of learning. Successful NPD projects typically rely on knowledge and experience of multi-function teams. In addition to corporate strategy and organization learning, the external factors such as, market and competitive conditions also play a big role in driving business strategies. The results from the empirical research study reported shows that companies implementing innovation strategy are more competitive in the long run while those that follow customer-responsive strategy are more likely to have higher return on investment within a shorter time. In order to achieve both sustainable competencies and also meet customer needs in the changing market environment today, a company should adapt to the benefits of both strategies.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 212 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -There is a unity to physics; it is a discipline which provides the most fundamental understanding of the dynamics of matter and energy. To understand anything about a physical system you have to interact with it and one of the best ways to learn something is to use electrons as probes. This book is the result of a meeting, which took place in Magdalene College Cambridge in December 2001. Atomic, nuclear, cluster, soHd state, chemical and even bio- physicists got together to consider scattering electrons to explore matter in all its forms. Theory and experiment were represented in about equal measure. It was meeting marked by the most lively of discussions and the free exchange of ideas. We all learnt a lot. The Editors are grateful to EPSRC through its Collaborative Computational Project program (CCP2), lOPP, the Division of Atomic, Molecular, Optical and Plasma Physics (DAMOPP) and the Atomic Molecular Interactions group (AMIG) of the Institute of Physics for financial support. The smooth running of the meeting was enormously facilitated by the efficiency and helpfulness of the staff of Magdalene College, for which we are extremely grateful. This meeting marked the end for one of us (CTW) of a ten-year period as a fellow of the College and he would like to take this opportunity to thank the fellows and staff for the privilege of working with them.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 356 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -These proceedings provide a forum for chemical scientists and engineers dedicated to making a cleaner, healthier world for everyone. They cover a wide range of related subjects such as environmental monitoring, wastewater treatment, and sludge management. 304 pp. Englisch. …