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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Master's Thesis from the year 2019 in the subject Chemistry - General, grade: 4.0, Mansoura University, language: English, abstract: Iron-overload disorder (hemochromatosis) is one of the major reasons of morbidity, caused by genetic disorder of protein involved in regulation of iron absorption or due to multiple transfusion of iron in chronic anemia for example thalassemia. Resulting in initiation and propagation reactive oxygen species which attacking macromolecules of cells such as proteins, lipids, RNA and DNA and ultimately cells death. Leading to a state of oxidative stress associated with many of health problems such as heart failure, liver cirrhosis, fibrosis, gallbladder disorders, diabetes, arthritis, infertility, and cancer. The available chelators drugs can forming soluble, stable complexes with excessive iron andexcreted it in the feces and/or urine. But due to, their high cost, severe side effects, poor oralbioavailability or short plasma half-life make them suboptimal.Sixteen plant leaves were collected, authenticated and subjected to exhausted extraction by 70% methanol. The obtained leaves extracts were screened for their iron chelation activity using 2,2`- bipyridyl assay. Among the screened extracts, the Mangiferaindica leaves showed the highest iron chelation activity(69.71 ± 0.27%)comparable to positive control, EDTA(70.30 ± 0.08%).The total extract of theM. indica leaves was partitioned with different solvents (petroleum ether, methylene chloride, ethyl acetate and n-butanol). The resultingfractions were screened for their iron chelation activity using 2, 2`- bipyridyl assay.EtOAcfractionhad the significant chelating activity (123 ± 2.75%),more potent than EDTA(64.12 ± 1.48%) and total extract of M. indica leaves (69.71 ± 0.27%).The mangiferin compound was subjected to comparison with desferal® to assurance the quality of its chelating activity throughdetermine the active sites responsible of its chelating property and evaluation the effect of its iron-stable complex on its antioxidant activity.According to introduced results, through different biological analysis. We found that, the iron-overloaded rats treated with ethyl acetate fraction had significant decreases in iron accumulation within liver and spleen (the major organs affected by iron overload). We assume that, the mangiferin may protect from reactive oxygenspecies-stimulatedseveral of disordersby its iron chelatingactivity which promotes its antioxidant property. …

Taschenbuch. Zustand: Neu. Neuware - Master's Thesis from the year 2016 in the subject Medicine - Pharmacology, , language: English, abstract: The aim of the present study is (1) the screening group of plants that are traditionally used as immune-enhancers in an attempt to find the major fractions that are responsible for the activity of these plants and correlating them with already published studies. (2) The Modification of structure of the most active immunomodulatory component through semisynthetic derivatization reactions. The modifications will be made in pursuance of gaining a deeper insight of the structural requirements for immunomodulatory activity. (3) Testing the immunomodulatory activities of both natural and semisynthetic compounds. And (4) studying the mechanism of action of the active compounds as antioxidantand anti-proliferative.Immunity is the body ability to identify and resist harmful pathogen. Metaphorically, the immunity is the body's army that enables prevention as well as fighting of infectious diseasestoprotect self-tissues and organs from damage.The immune system has a multi-layered construction with multiple defense stages. The skin is considered the first barrier of immunity. Then, physiological barriers take place, which are body physical conditions for examplepH and temperature that affordunsuitableenvironments for pathogens to live. Then, if a pathogen has escaped the first barriers and entered the body, it deals with innate immunity as well as acquired and/or adaptive immunity. Both systems consist of number of molecules and cells that interact in a complex manner to detect and eliminate any threat. Detection as well as elimination relay on bonding of immune cellular surface receptors as well as chemical binding to pathogens to trigger complex interaction of signaling of immune response.…

Taschenbuch. Zustand: Neu. Gingerols: New Therapeutics Applications | Emerging New Therapy Against Colorectal Cancer and Human Drug Resistant Breast Cancer | Fatma M. Abdel Bar (u. a.) | Taschenbuch | 116 S. | Englisch | 2015 | LAP LAMBERT Academic Publishing | EAN 9783659677625 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.…

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